Hai Tran Pham

US Patent:

6758080, Jul 6, 2004

Filed:

Nov 14, 2001

Appl. No.:

09/914422

Inventors:

Glen Ragan - Sugar Land TX
David Wilson - Missouri City TX
Jeffrey C. Gannon - Houston TX
Hai T. Pham - Sugar Land TX

Assignee:

Input/Output, Inc. - Stafford TX

International Classification:

G05B 1942

US Classification:

73 138

Abstract:

A plurality of seismic sensors calibration method ( ) includes: an assembling so that sensors are coupled with each sensor positioned with its axis of sensitivity in a different spatial direction calibration system step ( ), a rotating sensors step ( ), a measuring sensors output signals step ( ), a sensor output signal processing step ( ) and a storing calibration coefficient(s) step ( ).

US Patent:

7419808, Sep 2, 2008

Filed:

Mar 15, 2005

Appl. No.:

11/079986

Inventors:

Shuyuan Zhang - Sugar Land TX, US
Hai Pham - Houston TX, US

Assignee:

Introgen Therapeutics, Inc. - Austin TX

International Classification:

C12P 21/04
A61K 39/00
A61K 39/235
C12N 13/00
A61K 39/193

US Classification:

435 701, 4241841, 4242331, 4351739

Abstract:

The present invention addresses the need to improve the yield of adenovirus when grown in cell culture systems. In particular, it has been demonstrated that for adenovirus, the use of infection temperatures lower than 37 C. in a cell culture system results in improved yields of adenovirus. In addition, it has been demonstrated that when host cells are grow in a bioreactor, initiating adenovirus infection by diluting the host cells with fresh media and adenovirus results in improved yield of adenovirus. Methods of adenoviral production and purification using infection temperatures less than 37 C. are disclosed. Methods of adenoviral production and purification wherein the host cells are grown in a bioreactor and adenovirus infection is initiated by diluting the host cells with fresh media and adenovirus are also disclosed.

US Patent:

20040229335, Nov 18, 2004

Filed:

May 15, 2003

Appl. No.:

10/439278

Inventors:

Shuyuan Zhang - Sugar Land TX, US
Hai Pham - Houston TX, US

Assignee:

Introgen Therapeutics, Inc.

International Classification:

C12Q001/68
C12N007/01
C12N015/861

US Classification:

435/235100, 435/456000

Abstract:

The present invention addresses the need to improve the yield of adenovirus when grown in cell culture systems. In particular, it has been demonstrated that for adenovirus, the use of infection temperatures lower than 37 C. in a cell culture system results in improved yields of adenovirus. In addition, it has been demonstrated that when host cells are grow in a bioreactor, initiating adenovirus infection by diluting the host cells with fresh media and adenovirus results in improved yield of adenovirus. Methods of adenoviral production and purification using infection temperatures less than 37 C. are disclosed. Methods of adenoviral production and purification wherein the host cells are grown in a bioreactor and adenovirus infection is initiated by diluting the host cells with fresh media and adenovirus are also disclosed.

US Patent:

20060275781, Dec 7, 2006

Filed:

Jul 22, 2005

Appl. No.:

11/187319

Inventors:

Hai Pham - Houston TX, US
Shuyuan Zhang - Sugar Land TX, US
Peter Clarke - Sugar Land TX, US

Assignee:

INTROGEN THERAPEUTICS INC. - Austin TX

International Classification:

C12Q 1/70
C12Q 1/68

US Classification:

435006000, 435005000

Abstract:

The present invention relates to improved methods for producing adenovirus compositions wherein host cells are grown in a bioreactor and purified by size partitioning purification to provide purified adenovirus compositions.

US Patent:

20070172846, Jul 26, 2007

Filed:

Nov 13, 2006

Appl. No.:

11/559277

Inventors:

Shuyuan Zhang - Sugar Land TX, US
Hai Pham - Houston TX, US
Ping Song - Houston TX, US
Peter Clarke - Sugar Land TX, US

Assignee:

INTROGEN THERAPEUTICS, INC. - Austin TX

International Classification:

C12Q 1/70
C12Q 1/68
C12N 5/00
C12N 5/02

US Classification:

435006000, 435325000, 435005000

Abstract:

The present invention relates to compositions comprising and methods for producing adenovirus compositions wherein host cells are grown in a bioreactor and purified by size partitioning purification to provide purified adenovirus compositions.

US Patent:

20080044378, Feb 21, 2008

Filed:

May 15, 2007

Appl. No.:

11/748826

Inventors:

Shuyuan Zhang - Sugar Land TX, US
Hai Pham - Houston TX, US
Ping Song - Houston TX, US
Mingzhong Zheng - Houston TX, US
Peter Clarke - Sugar Land TX, US

Assignee:

INTROGEN THERAPEUTICS, INC. - Austin TX

International Classification:

A61K 31/395
A61K 31/70
A61K 38/00
A61P 43/00
C12N 15/00

US Classification:

424085200, 424130100, 424141100, 424094630, 435320100, 435069100, 514012000, 514044000

Abstract:

The present invention provides methods and compositions for recombinant protein production through replication-defective adenoviral vector infection of non-trans-complementation cell lines. Thus, this invention describes methods of heterologous protein production without an accompanied production of adenoviral vectors.

US Patent:

20100105124, Apr 29, 2010

Filed:

Oct 28, 2009

Appl. No.:

12/607791

Inventors:

Hai Pham - Houston TX, US
Shuyuan Zhang - Sugar Land TX, US
Peter Clarke - Sugar Land TX, US

International Classification:

C12N 7/02

US Classification:

435239

Abstract:

The present invention relates to improved methods for producing adenovirus compositions wherein host cells are grown in a bioreactor and purified by size partitioning purification to provide purified adenovirus compositions.