Peter Peizhi Luo - Lansdale PA, US Pingyu Zhong - Blue Bell PA, US Mark Hsieh - Jenkintown PA, US Yan Li - San Jose CA, US Xinwei Wang - Germantown MD, US Feng Dong - Lansdale PA, US Andrei Golosov - Cambridge MA, US Yan Ni - Westfield NJ, US Weirong Wang - Harleysville PA, US Laurence B. Peterson - Westfield NJ, US Rose Cubbon - Fanwood NJ, US Sujata Sharma - Eagleville PA, US Jon Condra - Doylestown PA, US Jun Lu - Lansdale PA, US Gopalakrishnan Parthasarathy - Hillsborough NJ, US Stephen Soisson - Hillsborough NJ, US Noel Byrne - Doylestown PA, US
Antagonists of human proprotein convertase subtilisin-kexin type 9 (“PCSK9”) are disclosed. The disclosed antagonists are effective in the inhibition of PCSK9 function and, accordingly, present desirable antagonists for use in the treatment of conditions associated with PCSK9 activity. The present invention also discloses nucleic acid encoding said antagonists, vectors, host cells, and compositions comprising the antagonists. Methods of making PCSK9-specific antagonists as well as methods of using the antagonists for inhibiting or antagonizing PCSK9 function are also disclosed and form important additional aspects of the present disclosure.
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