Gil Jae Lee

US Patent:

6676904, Jan 13, 2004

Filed:

Jul 12, 2000

Appl. No.:

09/614727

Inventors:

Gil U. Lee - West Lafayette IN 47906
Carolyn Yanavich - Alexandria VA 22314

International Classification:

B01L 1100

US Classification:

422101, 422 57, 422 58, 4221861, 422100, 4352871, 4352887, 436518

Abstract:

A sensor for a selected analyte in a test sample has (a) a semipermeable membrane with pores for retaining the analyte, where the membrane has been chemically modified by attachment of membrane modifiers; (b) immunoassay labels which have label binding ligands where these label binding ligands will have a binding affinity for the membrane modifiers in the presence of the analyte, and a measurably different binding affinity for the membrane modifiers in the absence of the analyte; and (c) a label detecting system, for detecting the presence of the labels on the membrane.

US Patent:

7037425, May 2, 2006

Filed:

Dec 6, 2002

Appl. No.:

10/313376

Inventors:

Gil U. Lee - West Lafayette IN, US
Sang Won Lee - Burbank CA, US

Assignee:

Purdue Research Foundation - West Lafayette IN

International Classification:

B01D 63/00

US Classification:

21032175, 2103216, 21050025, 21050026, 210490, 21050027, 422 99, 422101, 422 57, 422 58, 4221861, 436518

Abstract:

A process and apparatus for the collection of biological materials from air. Collection and separation devices utilize a novel membrane structure formed from a functionalized inorganic mesoporous membrane supported by porous substrate.

US Patent:

7118923, Oct 10, 2006

Filed:

Dec 15, 2003

Appl. No.:

10/734241

Inventors:

Gil U. Lee - West Lafayette IN, US
Carolyn Yanavich - Alexandria VA, US

Assignee:

The United States of America as represented by the Secretary of the Navy - Washington DC

International Classification:

G01N 33/543

US Classification:

436518, 436524, 436164, 436172, 435 6, 435 71, 4352871, 435422, 435101

Abstract:

A sensor for a selected analyte in a test sample has (a) a semipermeable membrane with pores for retaining the analyte, where the membrane has been chemically modified by attachment of membrane modifiers; (b) immunoassay labels which have label binding ligands where these label binding ligands will have a binding affinity for the membrane modifiers in the presence of the analyte, and a measurably different binding affinity for the membrane modifiers in the absence of the analyte; and (c) a label detecting system, for detecting the presence of the labels on the membrane.

US Patent:

7341696, Mar 11, 2008

Filed:

Oct 5, 2006

Appl. No.:

11/538987

Inventors:

Gil U Lee - West Lafayette IN, US
Carolyn Yanavich - Alexandria VA, US

Assignee:

The United States of America as represented by the Secretary of the Navy - Washington DC

International Classification:

B01L 11/00

US Classification:

422101, 422 57, 4352872, 435 71

Abstract:

A sensor for a selected analyte in a test sample has (a) a semipermeable membrane with pores for retaining the analyte, where the membrane has been chemically modified by attachment of membrane modifiers; (b) immunoassay labels which have label binding ligands where these label binding ligands will have a binding affinity for the membrane modifiers in the presence of the analyte, and a measurably different binding affinity for the membrane modifiers in the absence of the analyte; and (c) a label detecting system, for detecting the presence of the labels on the membrane.

US Patent:

7374944, May 20, 2008

Filed:

Oct 3, 2002

Appl. No.:

10/491686

Inventors:

David H. Thompson - West Lafayette IN, US
Christine A. Hrycyna - Lafayette IN, US
Gil U. Lee - West Lafayette IN, US
Osman A. Basaran - West Lafayette IN, US
Kinam Park - West Lafayette IN, US
Igal Szleifer - Homewood IL, US

Assignee:

Purdue Research Foundation - West Lafayette IN

International Classification:

G01N 33/00

US Classification:

436 86, 436 71, 436169, 422 56, 422 58

Abstract:

Bioanalytical device that includes a biofunctional component and an optional sensor component. The device includes arrays of addressable, durable, asymmetric biofunctional membranes containing protein transducers capable of unidirectional transport of analytes. Suitable protein transducers include members of the ATP-binding cassette family, such as P-glycoprotein.

US Patent:

20040086885, May 6, 2004

Filed:

Feb 24, 2003

Appl. No.:

10/373600

Inventors:

Gil Lee - West Lafayette IN, US
Ronald Andres - Lafayette IN, US
Alicia Ng - Johor, MY
Sang Lee - West Lafayette IN, US

Assignee:

Purdue Research Foundation - West Lafayette IN

International Classification:

C12Q001/68
G01N033/553

US Classification:

435/006000, 436/526000

Abstract:

Biological material in a sample is reacted with a novel functionalized superparamagnetic Fe/Au nanoparticle that specifically binds to the biological material to produce a magnetic particle/biological material complex. The biological material is detected upon application of an electromagnetic magnetic field which separates the magnetic bound complex from other components of the reaction mixture.

US Patent:

20050230272, Oct 20, 2005

Filed:

Jan 14, 2005

Appl. No.:

11/035431

Inventors:

Gil Lee - West Lafayette IN, US
Jin-Won Park - West Lafayette IN, US
Zhigang Wang - Aurora CO, US

International Classification:

G01N027/26

US Classification:

205792000, 204403010, 427002110

Abstract:

This invention relates to the biosensor devices, their fabrication and use. The biosensor devices comprise a substrate supporting an array of microwells where each microwell can contain a biocompatible fluid and a membrane having a membrane protein of interest. In use the microwells can be addressable to detect and analyze a variety of analytes.

US Patent:

20060275757, Dec 7, 2006

Filed:

Jun 30, 2003

Appl. No.:

10/519021

Inventors:

Gil Lee - West Lafayette IN, US
Ronald Andres - West Lafayette IN, US

International Classification:

C12Q 1/68
G01N 33/551
G01N 33/53

US Classification:

435006000, 435007100, 436524000, 977900000, 977924000

Abstract:

Biological material in a sample is reacted with a novel functionalized superparamagnetic Fe/Au nanoparticle that specifically binds to the biological material in solution to produce a magnetic particle/biological material complex. The biological material is detected upon application of an external magnetic field which separates the magnetic bound complex from other components of the reaction mixture.