Ghassan M Qabaja from 6335 Stonewick Dr, Jamestown, NC 27282, age 57

Us Patents

Azole Derivatives And Fused Bicyclic Azole Derivatives As Therapeutic Agents
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US Patent:

7737285, Jun 15, 2010
Filed:

May 3, 2007
Appl. No.:

11/800085
Inventors:

Adnan M. M. Mjalli - Oak Ridge NC, US
Robert C. Andrews - Jamestown NC, US
Ramesh Gopalaswamy - Jamestown NC, US
Anitha Hari - High Point NC, US
Kwasi A. Avor - High Point NC, US
Ghassan Qabaja - Jamestown NC, US
Xiao-Chuan Guo - High Point NC, US
Suparna Gupta - Greensboro NC, US
David R. Jones - Asheboro NC, US
Xin Chen - High Point NC, US
Assignee:

TransTech Pharma, Inc. - High Point NC
International Classification:

C07D 233/61
A01N 43/50
US Classification:

5483401, 514400
Abstract:

This invention provides certain compounds, methods of their preparation, pharmaceutical compositions comprising the compounds, and their use in treating human or animal disorders. The compounds of the invention are useful as modulators of the interaction between the receptor for advanced glycated end products (RAGE) and its ligands, such as advanced glycated end products (AGEs), S100/calgranulin/EN-RAGE, β-amyloid and amphoterin, and for the management, treatment, control, or as an adjunct treatment for diseases in humans caused by RAGE. Such diseases or disease states include acute and chronic inflammation, the development of diabetic late complications such as increased vascular permeability, nephropathy, atherosclerosis, and retinopathy, the development of Alzheimer's disease, erectile dysfunction, and tumor invasion and metastasis.

Substituted Heteroaryl Derivatives, Compositions, And Methods Of Use
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US Patent:

7820704, Oct 26, 2010
Filed:

Apr 20, 2005
Appl. No.:

11/110499
Inventors:

Adnan M. M. Mjalli - Jamestown NC, US
Bapu R. Gaddam - Greensboro NC, US
Ghassan Qabaja - High Point NC, US
Govindan Subramanian - High Point NC, US
Jeff Zhu - Greensboro NC, US
John Dankwardt - Westborough MA, US
Murty N. Arimilli - Oak Ridge NC, US
Robert C. Andrews - Jamestown NC, US
Samuel Victory - Oak Ridge NC, US
Ye E. Tian - Jamestown NC, US
Assignee:

TransTech Pharma, Inc. - High Point NC
International Classification:

A61K 31/427
A61K 31/381
C07D 277/38
C07D 409/12
US Classification:

514370, 514444, 548194, 549 59
Abstract:

The present invention provides substituted heteroaryl derivatives of Formula (I), methods of their preparation, pharmaceutical compositions comprising the compounds of Formula (I), and methods of use in treating human or animal disorders. The compounds of the invention can be useful as inhibitors of action of AgRP on a melanocortin receptor and thus can be useful for the management, treatment, control, or the adjunct treatment of diseases which may be responsive to the modulation of melanocortin receptors including obesity-related disorders.

Phenyl-Heteroaryl Derivatives And Methods Of Use Thereof
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US Patent:

8431575, Apr 30, 2013
Filed:

Feb 15, 2011
Appl. No.:

13/028036
Inventors:

Devi R Gohimukkula - Jamestown NC, US
David Robert Jones - Milford OH, US
Ghassan Qabaja - Jamestown NC, US
Jeff J Zhu - Winston Salem NC, US
Jeremy T Cooper - High Point NC, US
William K Banner - Greensboro NC, US
Kurt Sundermann - Summerfield NC, US
Muralidhar Bondlela - Greensboro NC, US
Mohan Rao - Greensboro NC, US
Pingzhen Wang - Kernersville NC, US
Suparna Gupta - Greensboro NC, US
Anitha Hari - High Point NC, US
Raju B Gowda - Oak Ridge NC, US
Robert C Andrews - Jamestown NC, US
Assignee:

TransTech Pharma, Inc. - High Point NC
International Classification:

A01N 43/58
A01N 43/60
A61K 31/50
A61K 31/495
US Classification:

514248, 544224
Abstract:

The present invention provides phenyl-heteroaryl derivatives of Formula (I) and pharmaceutically acceptable salts thereofThe present invention further relates to methods for the preparation of compounds of Formula (I) and pharmaceutically acceptable salts thereof, pharmaceutical compositions comprising such compounds, and the use of such compounds and/or pharmaceutical compositions in treating RAGE-mediated diseases.

Azole Derivatives And Fused Bicyclic Azole Derivatives As Therapeutic Agents
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US Patent:

7361678, Apr 22, 2008
Filed:

Mar 5, 2003
Appl. No.:

10/382203
Inventors:

Adnan M. M. Mjalli - Oak Ridge NC, US
Robert C. Andrews - Jamestown NC, US
Ramesh Gopalaswamy - Jamestown NC, US
Anitha Hari - High Point NC, US
Kwasi S. Avor - High Point NC, US
Ghassan Qabaja - Jamestown NC, US
Xiao-Chuan Guo - High Point NC, US
Suparna Gupta - Greensboro NC, US
David R. Jones - Asheboro NC, US
Xin Chen - High Point NC, US
Assignee:

TransTech Pharma, Inc. - High Point NC
International Classification:

A61K 31/4164
A61K 31/4178
C07D 233/64
C07D 403/02
US Classification:

514397, 514399, 548110, 5483147, 5483361
Abstract:

This invention provides certain compounds, methods of their preparation, pharmaceutical compositions comprising the compounds, and their use in treating human or animal disorders. The compounds of the invention are useful as modulators of the interaction between the receptor for advanced glycated end products (RAGE) and its ligands, such as advanced glycated end products (AGEs), S100/calgranulin/EN-RAGE, β-amyloid and amphoterin, and for the management, treatment, control, or as an adjunct treatment for diseases in humans caused by RAGE. Such diseases or disease states include acute and chronic inflammation, the development of diabetic late complications such as increased vascular permeability, nephropathy, atherosclerosis, and retinopathy, the development of Alzheimer's disease, erectile dysfunction, and tumor invasion and metastasis.

Azole Derivatives And Fused Bicyclic Azole Derivatives As Therapeutic Agents
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US Patent:

20070021386, Jan 25, 2007
Filed:

Aug 28, 2006
Appl. No.:

11/511163
Inventors:

Adnan Mjalli - Oak Ridge NC, US
Robert Andrews - Jamestown NC, US
Ramesh Gopalaswamy - Jamestown NC, US
Anitha Hari - High Point NC, US
Kwasi Avor - High Point NC, US
Ghassan Qabaja - Jamestown NC, US
Xiao-Chuan Guo - High Point NC, US
Suparna Gupta - Greensboro NC, US
David Jones - Asheboro NC, US
Xin Chen - High Point NC, US
Assignee:

TransTech Pharma - High Point NC
International Classification:

A61K 31/695
A61K 31/4172
US Classification:

514063000, 514396000, 514400000
Abstract:

This invention provides certain compounds, methods of their preparation, pharmaceutical compositions comprising the compounds, and their use in treating human or animal disorders. The compounds of the invention are useful as modulators of the interaction between the receptor for advanced glycated end products (RAGE) and its ligands, such as advanced glycated end products (AGEs), S100/calgranulin/EN-RAGE, β-amyloid and amphoterin, and for the management, treatment, control, or as an adjunct treatment for diseases in humans caused by RAGE. Such diseases or disease states include acute and chronic inflammation, the development of diabetic late complications such as increased vascular permeability, nephropathy, atherosclerosis, and retinopathy, the development of Alzheimer's disease, erectile dysfunction, and tumor invasion and metastasis.

Azole Derivatives And Fused Bicyclic Azole Derivatives As Therapeutic Agents
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US Patent:

20100256119, Oct 7, 2010
Filed:

May 5, 2010
Appl. No.:

12/799971
Inventors:

Adnan M.M. Mjalli - Jamestown NC, US
Robert C. Andrews - Jamestown NC, US
Ramesh Gopalaswamy - Jamestown NC, US
Anitha Hari - High Point NC, US
Kwasi S. Avor - High Point NC, US
Ghassan Qabaja - High Point NC, US
Xiao-Chuan Guo - High Point NC, US
Suparna Gupta - Greensboro NC, US
David R. Jones - Asheboro NC, US
Xin Chen - High Point NC, US
International Classification:

A61K 31/55
A61K 31/496
A61K 31/4184
A61K 31/454
A61K 31/439
A61K 31/5377
A61K 31/4545
A61K 31/4439
A61K 31/4164
A61K 31/422
A61K 31/4178
A61K 31/4709
A61P 11/00
A61P 11/06
A61P 27/02
A61P 9/10
A61P 29/00
A61P 17/00
US Classification:

51421709, 51425406, 514394, 514322, 514305, 5142345, 514316, 514338, 514400, 51425405, 514326, 514378, 514397, 514314, 514341, 51425309, 514318
Abstract:

This invention provides certain compounds, methods of their preparation, pharmaceutical compositions comprising the compounds, and their use in treating human or animal disorders. The compounds of the invention are useful as modulators of the interaction between the receptor for advanced glycated end products (RAGE) and its ligands, such as advanced glycated end products (AGEs), S100/calgranulin/EN-RAGE, β-amyloid and amphoterin, and for the management, treatment, control, or as an adjunct treatment for diseases in humans caused by RAGE. Such diseases or disease states include acute and chronic inflammation, the development of diabetic late complications such as increased vascular permeability, nephrdpathy, atherosclerosis, and retinopathy, the development of Alzheimer's disease, erectile dysfunction, and tumor invasion and metastasis.

Azole Derivatives And Fused Bicyclic Azole Derivatives As Therapeutic Agents
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US Patent:

20120088778, Apr 12, 2012
Filed:

Oct 10, 2011
Appl. No.:

13/270208
Inventors:

Adnan M.M. Mjalli - Jamestown NC, US
Robert C. Andrews - Jamestown NC, US
Ramesh Gopalaswamy - Jamestown NC, US
Anitha Hari - High Point NC, US
Kwasi S. Avor - High Point NC, US
Ghassan Qabaja - High Point NC, US
Xiao-Chuan Guo - High Point NC, US
Suparna Gupta - Greensboro NC, US
David R. Jones - Asheboro NC, US
Xin Chen - High Point NC, US
Assignee:

TransTech Pharma, Inc. - High Point NC
International Classification:

A61K 31/496
A61K 31/4725
A61P 27/02
A61P 9/10
A61K 31/4178
A61K 31/422
A61K 31/4439
A61K 31/444
A61K 31/454
A61K 31/4164
US Classification:

51425309, 514326, 514310, 514399, 51425405, 514397, 514378, 514341, 514333
Abstract:

This invention provides certain compounds, methods of their preparation, pharmaceutical compositions comprising the compounds, and their use in treating human or animal disorders. The compounds of the invention are useful as modulators of the interaction between the receptor for advanced glycated end products (RAGE) and its ligands, such as advanced glycated end products (AGEs), S100/calgranulin/EN-RAGE, β-amyloid and amphoterin, and for the management, treatment, control, or as an adjunct treatment for diseases in humans caused by RAGE. Such diseases or disease states include acute and chronic inflammation, the development of diabetic late complications such as increased vascular permeability, nephropathy, atherosclerosis, and retinopathy, the development of Alzheimer's disease, erectile dysfunction, and tumor invasion and metastasis.

Phenyl-Heteroaryl Derivatives And Methods Of Use Thereof
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US Patent:

20130197007, Aug 1, 2013
Filed:

Feb 21, 2013
Appl. No.:

13/772685
Inventors:

David Jones - Milford OH, US
Ghassan Qabaja - Jamestown NC, US
Jeff J. Zhu - Winston-Salem NC, US
Jeremy T. Cooper - High Point NC, US
William K. Banner - Greensboro NC, US
Kurt Sundermann - Summerfield NC, US
Muralidhar Bondlela - Greensboro NC, US
Mohan Rao - Greensboro NC, US
Pingzhen Wang - Kernersville NC, US
Raju B. Gowda - Oak Ridge NC, US
Robert C. Andrews - Jamestown NC, US
Suparna Gupta - Greensboro NC, US
Anitha Hari - High Point NC, US
Assignee:

TRANSTECH PHARMA, INC. - High Point NC
International Classification:

C07D 401/12
US Classification:

51425203
Abstract:

The present invention provides phenyl-heteroaryl derivatives of Formula (I) and pharmaceutically acceptable salts thereofThese compounds are useful in the treatment of RAGE-mediated diseases such as Alzheimer's Disease.The present invention further relates to methods for the preparation of compounds of Formula (I) and pharmaceutically acceptable salts thereof, pharmaceutical compositions comprising such compounds, and the use of such compounds and/or pharmaceutical compositions in treating RAGE-mediated diseases.

Resumes

Research Scientist

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Location:

Jamestown, NC

Industry:

Biotechnology

Work:

Unc Greensboro
Research Scientist
Transtech Pharma Mar 2001 - Jan 2009
Senior Research Scientist
Northeastern University 1997 - 2000
Student

Education:

Northeastern University 1995 - 2000
Doctorates, Doctor of Philosophy, Organic Chemistry Yarmouk University 1990 - 1993
Master of Science, Masters, Organic Chemistry Yarmouk University 1986 - 1990
Bachelors, Bachelor of Science, Chemistry

Skills:

Hplc
Organic Synthesis
Organic Chemistry
Drug Discovery
Chemistry
Medicinal Chemistry
Drug Design
Nmr
Science
Biochemistry
Mass Spectrometry
Lc Ms
Chromatography
Biotechnology
Synthetic Organic Chemistry
Protein Chemistry
Chemdraw
Analytical Chemistry
Uv/Vis
Life Sciences
Purification
Gas Chromatography
Molecular Modeling
Assay Development
Technology Transfer
Lifesciences
Drug Delivery
Crystallization
Good Laboratory Practice
Lead Change
Higher Education
Asymmetric Synthesis
Asymmetric Catalysis
Nanotechnology
Nanobiotechnology
Polymer Chemistry
Polyurethane
College Teaching
Experimental Research
Design of Experiments
Formulation
Natural Products
Icp
Green Chemistry
Gmp
Cgmp Practices
Cgmp Manufacturing
Glp

Languages:

Arabic
English

Ghassan M Qabaja

Ghassan Qabaja Phones & Addresses

Work

Education

Skills

Languages

Emails

Industries

Us Patents

Azole Derivatives And Fused Bicyclic Azole Derivatives As Therapeutic Agents

Substituted Heteroaryl Derivatives, Compositions, And Methods Of Use

Phenyl-Heteroaryl Derivatives And Methods Of Use Thereof

Azole Derivatives And Fused Bicyclic Azole Derivatives As Therapeutic Agents

Azole Derivatives And Fused Bicyclic Azole Derivatives As Therapeutic Agents

Azole Derivatives And Fused Bicyclic Azole Derivatives As Therapeutic Agents

Azole Derivatives And Fused Bicyclic Azole Derivatives As Therapeutic Agents

Phenyl-Heteroaryl Derivatives And Methods Of Use Thereof

Resumes

Research Scientist