Gerard R Colca from 125 Kalamazoo Ave, Kalamazoo, MI 49007, age 74, Phone: 269 381-4342

Thiazolidinedione Analogues For The Treatment Of Metabolic Diseases
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US Patent:

8304441, Nov 6, 2012
Filed:

Nov 16, 2011
Appl. No.:

13/279657
Inventors:

Gerard R. Colca - Kalamazoo MI, US
Robert C. Gadwood - Portage MI, US
Tim Parker - Portage MI, US
Assignee:

Metabolic Solutions Development Company, LLC - Kalamazoo MI
International Classification:

A61K 31/426
C07D 277/04
US Classification:

514369, 548183
Abstract:

The present invention relates to thiazolidinedione analogues that are useful for treating hypertension, diabetes, and inflammatory diseases.

Thiazolidinedione Analogues
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US Patent:

8389556, Mar 5, 2013
Filed:

May 18, 2011
Appl. No.:

13/068708
Inventors:

Gerard R. Colca - Kalamazoo MI, US
Rolf F. Kletzien - Richland MI, US
Assignee:

Metabolic Soultions Development Company, LLC - Kalamazoo MI
International Classification:

A61K 31/426
A61K 31/427
US Classification:

514369
Abstract:

The present invention relates to methods of using thiazolidinedione analogues of formula I:.

Thiazolidinedione Analogues
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US Patent:

8629159, Jan 14, 2014
Filed:

Sep 16, 2008
Appl. No.:

12/283812
Inventors:

Gerard R. Colca - Kalamazoo MI, US
Rolf F. Kletzien - Richland MI, US
Assignee:

Metabolic Solutions Development Company, LLC - Kalamazoo MI
International Classification:

A01N 43/42
A61K 31/44
US Classification:

514293, 514183, 514366
Abstract:

The present invention relates to thiazolidinedione analogues that are useful for treating hypertension.

Combination Therapies Of Thiazolidinedione Analogues
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US Patent:

20090143441, Jun 4, 2009
Filed:

Sep 16, 2008
Appl. No.:

12/283801
Inventors:

Gerard R. Colca - Kalamazoo MI, US
International Classification:

A61K 31/4439
A61P 25/00
US Classification:

514342
Abstract:

The present invention relates to thiazolidinedione analogues that are useful for treating inflammatory disease.

Thiazolidinedione Analogues
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US Patent:

20090143442, Jun 4, 2009
Filed:

Sep 16, 2008
Appl. No.:

12/283811
Inventors:

Gerard R. Colca - Kalamazoo MI, US
Rolf F. Kletzien - Richland MI, US
International Classification:

A61K 31/4439
A61P 29/00
US Classification:

514342
Abstract:

The present invention relates to thiazolidinedione analogues that are useful for treating metabolic inflammation mediated diseases such as diabetes.

Thiazolidinedione Analogues For The Treatment Of Hypertension
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US Patent:

20100222399, Sep 2, 2010
Filed:

Sep 15, 2008
Appl. No.:

12/677541
Inventors:

Gerard R. Colca - Kalamazoo MI, US
Robert C. Gadwood - Kalamazoo MI, US
Tim Parker - Kalamazoo MI, US
International Classification:

A61K 31/425
C07D 277/06
A61P 9/12
US Classification:

514369, 548183
Abstract:

The present invention relates to thiazolidinedione analogues that are useful for treating hypertension, diabetes, and inflammatory diseases. Formula (I), wherein: each of Rand Ris independently selected from H, halo, aliphatic, and alkoxy, wherein the aliphatic and alkoxy are optionally substituted with 1-3 of halo; Ris halo, hydroxy, or optionally substituted aliphatic, and R′is H, or Rand R′together form oxo; Ris H; and Ring A is a phenyl.

Ppar-Sparing Thiazolidinedione Salts For The Treatment Of Metabolic Diseases
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US Patent:

20120309975, Dec 6, 2012
Filed:

Dec 15, 2010
Appl. No.:

13/515508
Inventors:

Gerard R. Colca - Kalamazoo MI, US
Steven P. Tanis - Carlsbad CA, US
Scott D. Larsen - South Lyon MI, US
Assignee:

Metabolic Solutions Development Company LLC - Kalamazoo MI
International Classification:

C07D 277/34
C07F 9/6539
C07F 9/6571
C07D 417/12
US Classification:

5462697, 548183, 548119
Abstract:

The present invention relates to novel salts of thiazolidinediones and other pharmaceutical agents that are useful for treating and/or preventing metabolic diseases (e.g., diabetes, or neurodegenerative diseases (e.g., Alzheimer's Disease).

Ppar-Sparing Thiazolidinediones And Combinations For The Treatment Of Obesity And Other Metabolic Diseases
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US Patent:

20120316138, Dec 13, 2012
Filed:

Dec 15, 2010
Appl. No.:

13/515588
Inventors:

Gerard R. Colca - Kalamazoo MI, US
Rolf F. Kletzien - Richland MI, US
Steven P. Tanis - Carlsbad CA, US
Scott D. Larsen - South Lyon MI, US
Assignee:

METABOLIC SOLUTIONS DEVELOPMENT COMPANY, LLC - Kalamazoo MI
International Classification:

A61K 31/426
A61K 31/675
A61K 31/685
A61K 31/44
A61P 3/04
A61K 31/522
A61K 31/4458
A61K 31/472
A61K 31/5375
A61K 31/55
A61K 31/4439
A61K 31/4704
US Classification:

514 92, 514369, 514342, 514351, 514312, 51426332, 514317, 514307, 5142375, 51421402
Abstract:

The present invention relates to thiazolidinedione analogues and pharmaceutical compositions that are useful for treating and/or preventing obesity or diabetes, optionally in combination with a second treatment therapy such a diet restriction or an increase in duration or exertion in physical activity.

Gerard R Colca