Gerald S Rork

US Patent:

55828388, Dec 10, 1996

Filed:

Dec 22, 1994

Appl. No.:

8/363451

Inventors:

Gerald S. Rork - Lawrence KS
James D. Pipkin - Lawrence KS

Assignee:

Merck & Co., Inc. - Rahway NJ

International Classification:

A61K 924
A61K 932
A61K 936

US Classification:

424472

Abstract:

A device is disclosed for the controlled delivery of a beneficial agent, the device consisting of (i) a core comprising at least two layers, wherein at least one layer comprises a beneficial agent and a polymer which forms microscopic gel beads upon hydration and at least one layer which comprises a polymer which forms microscopic gel beads upon hydration; and (ii) an impermeable, insoluble coating which adheres to and surrounds the core and contains apertures which provide an area for the hydration and release of the microscopic gel beads.

US Patent:

48806315, Nov 14, 1989

Filed:

Sep 24, 1987

Appl. No.:

7/100665

Inventors:

John L. Haslam - Lawrence KS
Gerald S. Rork - Lawrence KS

Assignee:

Merck & Co., Inc. - Rahway NJ

International Classification:

A61K 3155

US Classification:

424424

Abstract:

The instant invention is directed to an osmotic pump, for the controlled release of diltiazem L-malate to an environment of use, said pump comprising: (A) a core which comprises a therapeutically effective amount of diltiazem L-malate and an effective buffering amount of sodium bitartrate surrounded by (B) a rate controlling water insoluble wall, having a fluid permeability of 6. 96. times. 10. sup. -18 to 6. 96. times. 10. sup. -14 cm. sup. 3 sec/g and a reflection coefficient of less than 0. 5, prepared from: (i) a polymer permeable to water but impermeable to solute and (ii) 0. 1 to 60% by weight, based on the total weight of (i) and (ii), of at least one pH insensitive pore forming additive dispersed throughout said wall.

US Patent:

58826823, Mar 16, 1999

Filed:

Aug 1, 1997

Appl. No.:

8/817129

Inventors:

Gerald S. Rork - Lawrence KS
James D. Pipkin - Lawrence KS

Assignee:

Merck & Co., Inc. - Rahway NJ

International Classification:

A61K 924

US Classification:

424473

Abstract:

Controlled delivery of a beneficial agent in a dispersion is provided using (i) a compressed core which contains the beneficial agent, a polymer which forms gelatinous microscopic particles upon hydration, and if desired, an agent to modulate the hydration; and (ii) a water insoluble coating which adheres to and surrounds the core and contains apertures which provide an area for the hydration and release of the dispersion. The release rate of the beneficial agent is a function of the number and size of the apertures in the coating.

US Patent:

49685074, Nov 6, 1990

Filed:

Jul 15, 1987

Appl. No.:

7/073781

Inventors:

Gaylen M. Zentner - Lawrence KS
Gerald S. Rork - Lawrence KS
Kenneth J. Himmelstein - Irvine CA

Assignee:

Merck & Co., Inc. - Rahway NJ

International Classification:

A61K 964

US Classification:

424465

Abstract:

The instant invention is directed to an osmotic pump comprising: (A) at least one active agent surrounded by (B) a rate controlling water insoluble wall, having a fluid permeability of 6. 96. times. 10. sup. -18 to 6. 96. times. 10. sup. -14 cm. sup. 3 sec/g and a reflection coefficient of less than 1, prepared from: (i) a polymer permeable to water but impermeable to solute and (ii) 0. 1 to 60% by weight, based on the total weight of (i) and (ii), of at least one pH insensitive pore forming additive dispersed throughout said wall.

US Patent:

53667387, Nov 22, 1994

Filed:

Sep 8, 1993

Appl. No.:

8/118836

Inventors:

Gerald S. Rork - Lawrence KS
James D. Pipkin - Lawrence KS

Assignee:

Merck & Co., Inc. - Rahway NJ

International Classification:

A61K 924

US Classification:

424473

Abstract:

A device for the controlled delivery of a beneficial agent as a gelatinous dispersion consisting of (i) a core which contains a beneficial agent, a polymer which forms gelatinous microscopic particles upon hydration and if desired an agent to modulate the hydration of the polymer; and (ii) an impermeable, insoluble coating which adheres to and surrounds the core and contains apertures which provide an area for the hydration and release of a dispersion comprising gelatinous microscopic particles.

US Patent:

55431542, Aug 6, 1996

Filed:

Oct 21, 1994

Appl. No.:

8/327083

Inventors:

Gerald S. Rork - Lawrence KS
James D. Pipkin - Lawrence KS

Assignee:

Merck & Co., Inc. - Rahway NJ

International Classification:

A61K 924

US Classification:

424473

Abstract:

A device for the controlled delivery of a beneficial agent as a gelatinous dispersion consisting of (i) a core which contains a beneficial agent, a polymer which forms gelatinous micoroscopic particles upon hydration and if desired an agent to modulate the hydration of the polymer; and (ii) an impermeable, insoluble coating which adheres to and surrounds the core and contains apertures which provide an area for the hydration and release of a disperson comprising gelatinous microscopic particles.

US Patent:

48512281, Jul 25, 1989

Filed:

Jul 15, 1987

Appl. No.:

7/073596

Inventors:

Gaylen M. Zentner - Lawrence KS
Kenneth J. Himmelstein - Irvine CA
Gerald S. Rork - Lawrence KS

Assignee:

Merck & Co., Inc. - Rahway NJ

International Classification:

A61K 964

US Classification:

424456

Abstract:

The instant invention is directed to a multiparticulate osmotic pump, for the controlled release of a pharmaceutically active agent to an environment of use, said pump comprising: (I) a carrier medium which does not maintain its integrity in the environment of use; (II) a multiple of tiny osmotic pump elements each consisting essentially of: (A) a core comprises at least one pharmacologically active agent soluble in an external fluid, or a mixture of an agent having a limited solubility in the external fluid with an osmotically effective solute that is soluble in the fluid, which exhibit an osmotic pressure gradient across the wall against the external fluid surrounded by (B) a rate controlling water insoluble wall, having a fluid permeability of 6. 96. times. 10. sup. -18 to 6. 96. times. 10. sup. 14 cm. sup. 3 sec/g and a reflection coefficient of less than 0. 5, prepared from: (i) a polymer permeable to water but impermeable to solute and (ii) 0.

US Patent:

48866687, Dec 12, 1989

Filed:

Sep 24, 1987

Appl. No.:

7/100676

Inventors:

John L. Haslam - Lawrence KS
Gerald S. Rork - Lawrence KS

Assignee:

Merck & Co., Inc. - Rahway NJ

International Classification:

A61K 3155

US Classification:

424424

Abstract:

The instant invention is directed to a multiparticulate osmotic pump, for the controlled release of diltiazem L-malate to an environment of use, said pump comprising: (I) a carrier medium which does not maintain its integrity in the environment of use; (II) a multiple of tiny osmotic pump elements each comprising: (A) a core comprises diltiazem L-malate and an effective buffering amount of sodium bitartrate surrounded by (B) a rate controlling water insoluble wall, having a fluid permeability of 6. 96. times. 10. sup. -18 to 6. 96. times. 10. sup. -14 cm. sup. 3 sec/g and a reflection coefficient of less than 0. 5, prepared from: (i) a polymer permeable to water but impermeable to solute and (ii) 0. 1 to 60% by weight, based on the total weight of (i) and (ii), of at least one pH insensitive pore forming additive dispersed throughout said wall, wherein the total amount of diltiazem L-malate in all of the osmotic pump elements is a therapeutically effective amount.