George R Tonn

US Patent:

20040242498, Dec 2, 2004

Filed:

Feb 26, 2004

Appl. No.:

10/789165

Inventors:

Tassie Collins - San Mateo CA, US
Michael Johnson - San Francisco CA, US
Ji Ma - Foster City CA, US
Julio Medina - San Carlos CA, US
Shichang Miao - Foster City CA, US
George Tonn - San Carlos CA, US
manfred schneider - brooklyn NY, US

International Classification:

A61K031/7052
C07D487/02
A61K031/519

US Classification:

514/023000, 514/264100, 544/280000, 536/017400

Abstract:

Compounds, compositions and methods that are useful in the treatment of inflammatory and immune conditions and diseases are provided herein. In particular, the invention provides compounds which modulate the expression and/or function of a chemokine receptor. The subject methods are useful for the treatment of inflammatory and immunoregulatory disorders and diseases, such as multiple sclerosis, rheumatoid arthritis and type I diabetes.

US Patent:

20070015773, Jan 18, 2007

Filed:

Jun 26, 2006

Appl. No.:

11/475653

Inventors:

Philippe Bergeron - San Mateo CA, US
Xiaoqi Chen - Palo Alto CA, US
Xiaohui Du - Foster City CA, US
Jeffrey Deignan - San Francisco CA, US
Jason Duquette - San Mateo CA, US
Darin Gustin - Half Moon Bay CA, US
Julio Medina - San Carlos CA, US
Jeffrey Mihalic - San Francisco CA, US
George Tonn - San Carlos CA, US

International Classification:

A61K 31/517
C07D 403/02
C07D 239/91

US Classification:

514266200, 514266310, 544286000, 544284000

Abstract:

Compounds, compositions and methods that are useful in the treatment of inflammatory and immune conditions and diseases are provided herein. In particular, the invention provides aryl nitrile compounds which modulate the expression and/or function of a chemokine receptor. The subject methods are useful for the treatment of inflammatory and immunoregulatory disorders and diseases, such as multiple sclerosis, rheumatoid arthritis, type I diabetes, asthma, psoriasis and inflammatory bowel disease.