George J Landau

US Patent:

7785615, Aug 31, 2010

Filed:

May 28, 2004

Appl. No.:

10/856462

Inventors:

Vipul Bhupendra Davé - Hillsborough NJ, US
George Landau - Verona NJ, US
Premal Patel - Plainsboro NJ, US

Assignee:

Cordis Corporation - Miami Lakes FL

International Classification:

A61F 2/00

US Classification:

424423, 514772, 424422

Abstract:

A medical device for placement at a site in a patient's body and for controlling pH levels at the site in the patient's body includes one or more structural components made of a first biodegradable and/or bioabsorbable material or, alternatively, one or more structural components having a coating thereon made of a first biodegradable and/or bioabsorbable material. The device also includes a buffering agent and at least one second biodegradable and/or bioabsorbable material on or in the one or more structural components, or alternatively, on or in the coating on the one or more structural components. The at least one second biodegradable and/or bioabsorbable material encapsulates the buffering agent and the buffering agent is dispersed from the at least one second biodegradable and/or bioabsorbable material in response to hydrolysis of the first biodegradable and/or bioabsorbable material. Additionally, the device can include a drug that is either also encapsulated by the at least one second biodegradable and/or bioabsorbable material or is included with the first biodegradable and/or bioabsorbable material.

US Patent:

7803182, Sep 28, 2010

Filed:

May 28, 2004

Appl. No.:

10/856459

Inventors:

Vipul Bhupendra Davé - Hillsborough NJ, US
George Landau - Verona NJ, US
Premal Patel - Plainsboro NJ, US

Assignee:

Cordis Corporation - Miami Lakes FL

International Classification:

A61F 2/06
A61F 2/00

US Classification:

623 138, 424423

Abstract:

A vascular or cardiovascular medical device for placement at a site in a patient's body and for controlling pH levels at the site in the patient's body includes one or more structural components made of a biodegradable and/or bioabsorbable material, or alternatively, a coating thereon made of a biodegradable and/or bioabsorbable material. A buffering agent is provided on or in the biodegradable and/or bioabsorbable material and the buffering agent is dispersed from the biodegradable and/or bioabsorbable material in response to hydrolysis of the biodegradable and/or bioabsorbable material. Additionally, the vascular or cardiovascular medical device can include a drug that is included with the biodegradable and/or bioabsorbable material. The vascular or cardiovascular medical device can also be a stent or a valve.

US Patent:

8394488, Mar 12, 2013

Filed:

Oct 6, 2006

Appl. No.:

11/539355

Inventors:

Vipul Davé - Hillsborough NJ, US
George Landau - Huntingdon Valley PA, US

International Classification:

B32B 27/32
A61F 2/00
A61K 9/48
A61L 17/00

US Classification:

428220, 424426, 424423, 424 94, 424443, 424422, 606228, 606214, 623 115, 523105

Abstract:

A medical device has a structure made of a first biodegradable and/or bioabsorbable material and a second biodegradable and/or bioabsorbable material. The first biodegradable and/or bioabsorbable material has a degradation rate that is faster than a degradation rate of the second biodegradable and/or bioabsorbable material. And, the structure experiences a period of accelerated degradation upon exposure of the first biodegradable and/or bioabsorbable material.

US Patent:

20010029351, Oct 11, 2001

Filed:

May 7, 2001

Appl. No.:

09/850482

Inventors:

Robert Falotico - Belle Mead NJ, US
Gregory Kopia - Hillsborough NJ, US
George Landau - Verona NJ, US
Gerard Llanos - Stewartsville NJ, US
Pallassana Narayanan - Belle Mead NJ, US
George Papandreou - Kendall Park NJ, US

International Classification:

A61M029/00

US Classification:

604/103020, 623/001210

Abstract:

An intralumen medical device comprising anti-proliferative and anti-thrombotic or anti-coagulant drugs, agents or compounds may be utilized in the treatment of vascular disease. The intralumen medical device is selectively coated with the drugs, agents or compounds for local delivery, thereby increasing their effectiveness and reducing potential toxicity associated with systemic use. The selective coating is utilized to ensure that the specific drugs, agents or compounds come into contact with or are delivered to the appropriate tissues and/or fluids for maximum effectiveness.

US Patent:

20080085297, Apr 10, 2008

Filed:

Oct 6, 2006

Appl. No.:

11/539393

Inventors:

Vipul Dave - Hillsborough NJ, US
George Landau - Huntingdon Valley PA, US

International Classification:

A61F 2/02

US Classification:

424426, 977906

Abstract:

A medical device has a structure made of one biodegradable and/or bioabsorbable material. A degradation additive is encapsulated by another biodegradable and/or bioabsorbable material forming a nanoparticle or microparticle. The nanoparticle or microparticle is together with the one biodegradable and/or bioabsorbable material of the structure. The other biodegradable and/or bioabsorbable material of the nanoparticle or microparticle has a degradation rate that is faster than a degradation rate of the one biodegradable and/or bioabsorbable material. The structure experiences a period of accelerated degradation upon release of the degradation additive from the nanoparticle or microparticle.

US Patent:

20130144376, Jun 6, 2013

Filed:

Jan 28, 2013

Appl. No.:

13/752076

Inventors:

Cordis Corporation - Bridgewater NJ, US
George Landau - Huntingdon Valley PA, US

Assignee:

Cordis Corporation - Bridgewater NJ

International Classification:

A61F 2/82

US Classification:

623 134, 623 138

Abstract:

A medical device has a structure made of a first biodegradable and/or bioabsorbable material and a second biodegradable and/or bioabsorbable material encapsulating a degradation additive incorporated into the first biodegradable and/or bioabsorbable material. The second biodegradable and/or bioabsorbable material has a degradation rate that is faster than the degradation rate of the first biodegradable and/or bioabsorbable material such that the structure experiences a period of accelerated degradation upon release of the degradation additive following sufficient degradation of the second biodegradable and/or bioabsorbable material.

Author:

George W. Landau

ISBN #:

0930503627