George Edward Field

Author:

George Wallis Field

ISBN #:

0805724249

Author:

George Wallis Field

ISBN #:

0882540017

Author:

George Wallis Field

ISBN #:

3880990239

Author:

George B. Field

ISBN #:

0394742788

Author:

George B. Field

ISBN #:

0395253217

Author:

George B. Field

ISBN #:

0805325123

Author:

George B. Field

ISBN #:

0805325131

Author:

George B. Field

ISBN #:

0809244950

US Patent:

42386101, Dec 9, 1980

Filed:

Dec 20, 1979

Appl. No.:

6/105823

Inventors:

George F. Field - West Caldwell NJ
William J. Zally - Cresskill NJ

Assignee:

Hoffmann-La Roche Inc. - Nutley NJ

International Classification:

C07D23904
C07D24506

US Classification:

544283

Abstract:

Novel intermediates of the formula ##STR1## wherein X and Y are hydrogen, halogen or trifluoromethyl and R. sub. 1 is hydrogen or lower alkyl are presented. Also disclosed is a process leading to the intermediates and their conversion to imidazobenzodiazepines, compounds of pharmacological activity.

US Patent:

44607814, Jul 17, 1984

Filed:

Jan 5, 1983

Appl. No.:

6/455767

Inventors:

George F. Field - West Caldwell NJ
Rodney I. Fryer - North Caldwell NJ
Eugene J. Trybulski - Parsippany NJ
Armin Walser - West Caldwell NJ

Assignee:

Hoffmann-La Roche Inc. - Nutley NJ

International Classification:

C07D23106
C07D23114

US Classification:

548356

Abstract:

There are presented compounds of the formula ##STR1## wherein R. sub. 1 is hydrogen or lower alkyl; R. sub. 6 is halo and R. sub. 5 is hydrogen or halo; and compounds of the formulas ##STR2## wherein R. sub. 2 and R. sub. 3 are selected from the group consisting of hydrogen, lower alkyl, C. sub. 2 to C. sub. 7 carboxylic acids, hydroxy C. sub. 2 to C. sub. 7 alkyl, C. sub. 2 to C. sub. 7 carboxylic acid esters and amides and the group COR. sub. 11 wherein R. sub. 11 and is selected from the group consisting of alkoxy, amino or mono-lower alkyl amino; R. sub. 35 is hydrogen or lower alkyl; R. sub. 5 is hydrogen or halo; and R. sub. 7 is methyl or chloromethyl, all of which are useful in the preparation of pyrazolobenzazepines.

US Patent:

43797652, Apr 12, 1983

Filed:

Jul 23, 1981

Appl. No.:

6/286122

Inventors:

George F. Field - West Caldwell NJ
Rodney I. Fryer - North Caldwell NJ
Eugene J. Trybulski - Parsippany NJ
Armin Walser - West Caldwell NJ

Assignee:

Hoffmann-La Roche Inc. - Nutley NJ

International Classification:

A61K 3155
C07D48704

US Classification:

2602456

Abstract:

There are presented compounds of the formulas ##STR1## wherein R. sub. 1 is hydrogen or lower alkyl; R. sub. 2 and R. sub. 3 are selected from the group consisting of hydrogen, lower alkyl, C. sub. 2 to C. sub. 7 carboxylic acids, hydroxy C. sub. 2 to C. sub. 7 alkyl, C. sub. 2 to C. sub. 7 carboxylic acid esters and amides and the group COR. sub. 11 wherein R. sub. 11 is alkoxy, amino or mono- lower alkyl amino; R. sub. 6 is nitro or halo and R. sub. 5 is hydrogen or halo, and the pharmaceutically acceptable salts thereof. The pyrazolobenzazepines are useful as anxiolytic and sedative agents. Also provided are processes and intermediates in the production of the above pyrazolobenzazepines.

US Patent:

41940490, Mar 18, 1980

Filed:

Mar 29, 1979

Appl. No.:

6/025219

Inventors:

George F. Field - West Caldwell NJ
William J. Zally - Cresskill NJ

Assignee:

Hoffmann-La Roche Inc. - Nutley NJ

International Classification:

C07D40306

US Classification:

548336

Abstract:

A multistep process is presented for the preparation of imidazobenzodiazepines of the formula ##STR1## wherein X and Y are selected from the group consisting of hydrogen, halogen and trifluoromethyl. Also presented are novel intermediates utilized in the process. The end products are useful as sedatives, anxiolytics, muscle relaxants and anticonvulsants. The end products are especially useful in intravenous compositions for use in preoperative anesthesia.

US Patent:

40547400, Oct 18, 1977

Filed:

Sep 5, 1975

Appl. No.:

5/610707

Inventors:

George Francis Field - West Caldwell NJ

Assignee:

Hoffmann-La Roche Inc. - Nutley NJ

International Classification:

C07D49504

US Classification:

548303

Abstract:

This invention relates to a synthesis of biotin by the reduction of dehydrobiotin. The dehydrobiotin is prepared from 6-hydroxy-7-nitro-heptanoic acid methyl ester. Novel intermediates are also obtained by this synthesis.

US Patent:

42811422, Jul 28, 1981

Filed:

Sep 27, 1979

Appl. No.:

6/079288

Inventors:

George F. Field - West Caldwell NJ
William J. Zally - Cresskill NJ

Assignee:

Hoffmann-La Roche Inc. - Nutley NJ

International Classification:

C07D23364

US Classification:

548343

Abstract:

A multistep process is presented for the preparation of imidazobenzodiazepines of the formula ##STR1## wherein X and Y are selected from the group consisting of hydrogen, halogen and trifluoromethyl. Also presented are novel intermediates utilized in the process. The end products are useful as sedatives, anxiolytics, muscle relaxants and anticonvulsants. The end products are especially useful in intravenous compositions for use in preoperative anesthesia.

US Patent:

39547531, May 4, 1976

Filed:

Feb 13, 1975

Appl. No.:

5/549566

Inventors:

George Francis Field - West Caldwell NJ
Leo Henryk Sternbach - Upper Montclair NJ
Armin Walser - West Caldwell NJ

Assignee:

Hoffmann-La Roche Inc. - Nutley NJ

International Classification:

C07D24114

US Classification:

260250BN

Abstract:

Novel pyrazino-1,4-diazepines are disclosed together with processes for their preparation and novel intermediates used in these processes. These novel diazepines are useful as sedatives, muscle-relaxants and anti-convulsants.

US Patent:

45606927, Dec 24, 1985

Filed:

Jul 18, 1984

Appl. No.:

6/631971

Inventors:

George F. Field - West Caldwell NJ
William J. Zally - Cresskill NJ

Assignee:

Hoffmann-La Roche Inc. - Nutley NJ

International Classification:

A61K 3147
C07D21516

US Classification:

514313

Abstract:

Disclosed are compounds of the formula ##STR1## wherein: R. sup. 1 and R. sub. 2 may be either the same or different and each is hydrogen or lower alkyl; and wherein R. sup. 3 and R. sup. 4 may be either the same or different and each is hydrogen, halogen, or lower alkyl, with the proviso that R. sup. 3 and R. sup. 4 cannot both be hydrogen. These compounds are useful as anticonvulsant or anxiolytic agents.