George F Field

Author:

George Wallis Field

ISBN #:

0805724249

Author:

George Wallis Field

ISBN #:

0882540017

Author:

George Wallis Field

ISBN #:

3880990239

Author:

George B. Field

ISBN #:

0394742788

Author:

George B. Field

ISBN #:

0395253217

Author:

George B. Field

ISBN #:

0805325123

Author:

George B. Field

ISBN #:

0805325131

Author:

George B. Field

ISBN #:

0809244950

US Patent:

6465472, Oct 15, 2002

Filed:

Sep 1, 2000

Appl. No.:

09/654839

Inventors:

Ravi Upasani - San Jose CA
Sui X. Cai - San Diego CA
Nancy C. Lan - S. Pasadena CA
Yan Wang - San Diego CA
George Field - Danville CA
David B. Fick - Newport Beach CA

Assignee:

Euro-Celtique S.A. - Luxembourg

International Classification:

C07D23726

US Classification:

514258, 544284, 544286

Abstract:

The invention relates to novel quinazolines and heterocycles which are antagonists or positive modulators of AMPA receptors, and the use thereof for treating, preventing or ameliorating neuronal loss associated with stroke, global and focal ischemia, CNS trauma, hypoglycemia and surgery, as well as treating or ameliorating neurodegenerative diseases including Alzheimers disease, amyotrophic lateral sclerosis, Huntingtons disease, Parkinsons disease and Downs syndrome, treating, preventing or ameliorating the adverse consequences of the overstimulation of the excitatory amino acids, treating, preventing or ameliorating anxiety, psychosis, convulsions, chronic pain, glaucoma, retinitis, urinary incontinence, muscular spasm and inducing anesthesia, as well as for treating or ameliorating the adverse consequences of excitatory amino acid deficiency such as schizophrenia, myoclonus. Alzheimers disease and malnutrition and neural maldevelopment, and as cognition and learning enhancers.

US Patent:

7652006, Jan 26, 2010

Filed:

Feb 6, 2004

Appl. No.:

10/772445

Inventors:

Ravi Upasani - San Jose CA, US
Sui X Cai - San Diego CA, US
Nancy C Lan - Pasadena CA, US
Yan Wang - San Diego CA, US
George Field - Danville CA, US
David B Fick - Mission Viejo CA, US

Assignee:

Euro-Celtique S.A. - Luxembourg

International Classification:

C07D 487/04
A61K 31/5025
A61K 31/496
C07D 491/14
C07D 319/16
C07D 307/83
C07D 317/50
C07D 323/02
A61K 31/517
A61K 31/5355
A61K 31/497
A61P 25/18
A61P 25/28
A61P 25/08
A61P 25/00

US Classification:

514248, 544234, 544249, 5142328, 549439, 549366, 549435

Abstract:

The invention relates to novel quinazolines and heterocycles which are antagonists or positive modulators of AMPA receptors, and the use thereof for treating, preventing or ameliorating neuronal loss associated with stroke, global and focal ischemia, CNS trauma, hypoglycemia and surgery, as well as treating or ameliorating neurodegenerative diseases including Alzheimer's disease, amyotrophic lateral sclerosis, Huntington's disease, Parkinson's disease and Down's syndrome, treating, preventing or ameliorating the adverse consequences of the overstimulation of the excitatory amino acids, treating, preventing or ameliorating anxiety, psychosis, convulsions, chronic pain, glaucoma, retinitis, urinary incontinence, muscular spasm and inducing anesthesia, as well as for treating or ameliorating the adverse consequences of excitatory amino acid deficiency such as schizophrenia, myoclonus, Alzheimer's disease and malnutrition and neural maldevelopment, and as cognition and learning enhancers.

US Patent:

51498073, Sep 22, 1992

Filed:

Sep 18, 1991

Appl. No.:

7/761559

Inventors:

Peter R. Hammond - Livermore CA
George F. Field - Danville CA

Assignee:

The United States of America, as represented by the United States
Department of Energy - Washington DC

International Classification:

C07D49814
C07D49822

US Classification:

544 99

Abstract:

New oxazine compounds useful as dye laser media in solution, are superiior to prior art materials. The oxazine dyes useful when pumped by the 578. 2 nm copper line to operate in the 700-800 nm range are described by formula I ##STR1##.

US Patent:

52567990, Oct 26, 1993

Filed:

Jul 14, 1992

Appl. No.:

7/913084

Inventors:

George F. Field - Danville CA
Peter R. Hammond - Livermore CA

Assignee:

The United States of Americas as represented by the United States
Department of Energy - Washington DC

International Classification:

C07D21520

US Classification:

548469

Abstract:

A novel method for the synthesis of 6-hydroxyindolines and new fluorescent dyes produced therefrom, which dyes are ring-constrained indoline-based rhodamine class dyes. These dyes have absorption and emission spectra which make them particularly useful in certain dye laser applications.

US Patent:

42386101, Dec 9, 1980

Filed:

Dec 20, 1979

Appl. No.:

6/105823

Inventors:

George F. Field - West Caldwell NJ
William J. Zally - Cresskill NJ

Assignee:

Hoffmann-La Roche Inc. - Nutley NJ

International Classification:

C07D23904
C07D24506

US Classification:

544283

Abstract:

Novel intermediates of the formula ##STR1## wherein X and Y are hydrogen, halogen or trifluoromethyl and R. sub. 1 is hydrogen or lower alkyl are presented. Also disclosed is a process leading to the intermediates and their conversion to imidazobenzodiazepines, compounds of pharmacological activity.

US Patent:

52833364, Feb 1, 1994

Filed:

Sep 8, 1992

Appl. No.:

7/941813

Inventors:

George Field - Danville CA
Peter R. Hammond - Livermore CA

Assignee:

The United States of America as represented by the United States
Department of Energy - Washington DC

International Classification:

C07D21520

US Classification:

546179

Abstract:

Methods for the efficient preparation of 7-hydroxy-1,2,3,4-tetrahydroquinoline include a first method in which the acylation of m-aminophenol obtains a lactam which is reduced to give the desired quinoline and a second method in which tetrahydroquinoline is nitrated and hydrogenated and then hydrolyzed to obtain the desire quinoline. 7-hydroxy-1,2,3,4-tetrahydroquinoline is used in the efficient synthesis of four lasing dyes of the rhodamine class.

US Patent:

44607814, Jul 17, 1984

Filed:

Jan 5, 1983

Appl. No.:

6/455767

Inventors:

George F. Field - West Caldwell NJ
Rodney I. Fryer - North Caldwell NJ
Eugene J. Trybulski - Parsippany NJ
Armin Walser - West Caldwell NJ

Assignee:

Hoffmann-La Roche Inc. - Nutley NJ

International Classification:

C07D23106
C07D23114

US Classification:

548356

Abstract:

There are presented compounds of the formula ##STR1## wherein R. sub. 1 is hydrogen or lower alkyl; R. sub. 6 is halo and R. sub. 5 is hydrogen or halo; and compounds of the formulas ##STR2## wherein R. sub. 2 and R. sub. 3 are selected from the group consisting of hydrogen, lower alkyl, C. sub. 2 to C. sub. 7 carboxylic acids, hydroxy C. sub. 2 to C. sub. 7 alkyl, C. sub. 2 to C. sub. 7 carboxylic acid esters and amides and the group COR. sub. 11 wherein R. sub. 11 and is selected from the group consisting of alkoxy, amino or mono-lower alkyl amino; R. sub. 35 is hydrogen or lower alkyl; R. sub. 5 is hydrogen or halo; and R. sub. 7 is methyl or chloromethyl, all of which are useful in the preparation of pyrazolobenzazepines.

US Patent:

50011405, Mar 19, 1991

Filed:

Jun 13, 1989

Appl. No.:

7/366097

Inventors:

George F. Field - Danville CA
John R. Vermeulen - Wanaque NJ
William J. Zally - Cresskill NJ

Assignee:

Hoffmann-La Roche Inc. - Nutley NJ

International Classification:

C07D27730
A61K 31425

US Classification:

514365

Abstract:

The invention relates to compounds of the formula: ##STR1## wherein R is hydrogen or lower alkyl, R. sub. 1, R. sub. 2, R. sub. 3 and R. sub. 4, independently, are hydrogen, lower alkyl, lower alkenyl, cycloalkyl or phenyl unsubstituted or substituted by up to 3 substituents independently selected from lower alkyl, lower alkoxy or halogen, or R. sub. 1 and R. sub. 2 taken together with the carbon atom are alkylene of 2 to 5 carbon atoms unsubstituted or substituted by lower alkyl, and n is an integer of from 0 to 3, and, when R. sub. 1 is different from R. sub. 2 and/or when R. sub. 3 is different from R. sub. 4, enantiomers, diastereomers and racemates thereof and, when R is hydrogen, salts thereof with pharmaceutically acceptable bases. The compounds of formula I and, when R is hydrogen, pharmaceutically exceptable salts thereof are useful as bronchopulmonary agents, for example, in the relief of asthma and allergic reactions.