George D Chu

US Patent:

6482179, Nov 19, 2002

Filed:

May 24, 2000

Appl. No.:

09/578814

Inventors:

George H. Chu - Cupertino CA
Jeffrey E. Yeung - San Jose CA
Frank A. DeLustro - Belmont CA

Assignee:

Cohesion Technologies, Inc. - Palo Alto CA

International Classification:

A61M 5178

US Classification:

60416409, 606214

Abstract:

Medical devices, and more particularly, devices, methods and compositions for sealing tissue puncture openings of patients after surgical operations are provided. A puncture wound sealing apparatus includes a positioning device having a depth sensing mechanism capable of providing feedback to an operator for the precise placement of an implant that is preferably resorbable and swellable after implantation. Such an implant provides for efficient sealing of the tissue puncture opening thus avoiding complications after surgical procedures in which blood vessels are punctured.

US Patent:

6495127, Dec 17, 2002

Filed:

Aug 28, 2000

Appl. No.:

09/649337

Inventors:

Donald G. Wallace - Menlo Park CA
George H. Chu - Cupertino CA
Jacqueline Anne Schroeder - Boulder Creek CA

Assignee:

Cohesion Technologies, Inc. - Palo Alto CA

International Classification:

A61K 3174

US Classification:

424 7803, 424 7802, 424422, 424423, 424424, 424443, 424445, 424486

Abstract:

The present invention relates generally to synthetic polymer compositions that form interpenetrating polymer networks. In a preferred embodiment, the compositions comprise two multifunctionally activated synthetic polymers, along with a tensile strength enhancer. Such compositions form matrices that exhibit superior cohesive strength and in many instances can serve as adequate replacements for surgical means of attaching tissues, such as sutures and medical staples.

US Patent:

6833408, Dec 21, 2004

Filed:

Sep 30, 2002

Appl. No.:

10/262640

Inventors:

Louis C. Sehl - Redwood City CA
Olof Mikael Trollsas - Los Gatos CA
Donald G. Wallace - Menlo Park CA
David Toman - Atherton CA
Frank A. DeLustro - Belmont CA
Jacqueline A. Schroeder - Boulder Creek CA
George H. Chu - Cupertino CA

Assignee:

Cohesion Technologies, Inc. - Palo Alto CA

International Classification:

C08F28300

US Classification:

525 541, 525419, 525420, 525425, 424 7803, 424 7802, 424422, 424423, 424424, 424443, 424445, 424486

Abstract:

A method of tissue repair is provided using a biocompatible nonimmunogenic adhesive composition. The adhesive composition comprises collagen and a plurality of crosslinkable components having reactive functional groups thereon, with the functional groups selected so as to enable inter-reaction between the components, i. e. , crosslinking. Kits for use in carrying out the method of the invention are also provided, as are pretreated surgically acceptable patches that have been coated with the aforementioned adhesive composition.

US Patent:

7501693, Mar 10, 2009

Filed:

Nov 17, 2006

Appl. No.:

11/561175

Inventors:

George Chu - Fremont CA, US
Martin Alter - Los Altos CA, US

Assignee:

Micrel, Inc. - San Jose CA

International Classification:

H01L 23/495
H01L 23/04

US Classification:

257676, 257666, 257698, 257E23061

Abstract:

A low dropout (LDO) regulator device includes an LDO regulator integrated circuit housed in a 4-pin quad flat no-lead (QFN) package where the exposed die paddle is used as the ground terminal. The LDO regulator integrated circuit is formed on a semiconductor substrate. The 4-pin QFN package includes four perimeter lands connected to the input terminal, the output terminal, the enable terminal and the bypass terminal of the LDO regulator integrated circuit. The die paddle is to be electrically connected to a ground potential to allow the ground current of the LDO regulator integrated circuit to flow through the substrate and the die paddle of the 4-pin QFN package.

US Patent:

7883693, Feb 8, 2011

Filed:

Jan 31, 2006

Appl. No.:

11/344752

Inventors:

Louis C. Sehl - Redwood City CA, US
Olof Mikael Trollsas - San Jose CA, US
Donald G. Wallace - Menlo Park CA, US
David Toman - Atherton CA, US
Frank A. DeLustro - North Charleston SC, US
Jacqueline A. Schroeder - Boulder Creek CA, US
George H. Chu - Cupertino CA, US

Assignee:

AngioDevice International GmbH - Zug

International Classification:

A61K 31/785

US Classification:

424 7803

Abstract:

Crosslinkable compositions are provided that readily crosslink in situ to provide biocompatible, nonimmunogenic crosslinked materials that may be used as adhesive compositions. The compositions comprise collagen and a plurality of crosslinkable components having reactive functional groups thereon, with the functional groups selected so as to enable inter-reaction between the components, i. e. , crosslinking. Methods for preparing and using the compositions are also provided. Exemplary uses include tissue augmentation, biologically active agent delivery, bioadhesion, prevention of adhesions following surgery or injury, and coating of surgically acceptable patches and solid implants, the latter including sutures.

US Patent:

8377466, Feb 19, 2013

Filed:

Oct 22, 2004

Appl. No.:

10/971684

Inventors:

Louis C. Sehl - Redwood City CA, US
Olof Mikael Trollsas - Los Gatos CA, US
Donald G. Wallace - Menlo Park CA, US
David Toman - Atherton CA, US
Frank A. DeLustro - Belmont CA, US
Jacqueline A. Schroeder - Boulder Creek CA, US
George H. Chu - Cupertino CA, US

Assignee:

Angiotech Pharmaceuticals (US), Inc. - Bellevue WA

International Classification:

A61F 13/00

US Classification:

424443

Abstract:

A method of tissue repair is provided using a biocompatible nonimmunogenic adhesive composition. The adhesive composition comprises collagen and a plurality of crosslinkable components having reactive functional groups thereon, with the functional groups selected so as to enable inter-reaction between the components, i. e. , crosslinking. Kits for use in carrying out the method of the invention are also provided, as are pretreated surgically acceptable patches that have been coated with the aforementioned adhesive composition.

US Patent:

8617584, Dec 31, 2013

Filed:

May 25, 2010

Appl. No.:

12/787304

Inventors:

Louis C. Sehl - Redwood City CA, US
Olof Mikael Trollsas - Los Gatos CA, US
Donald G. Wallace - Menlo Park CA, US
David Toman - Atherton CA, US
Frank A. DeLustro - Belmont CA, US
Jacqueline A. Schroeder - Boulder Creek CA, US
George H. Chu - Cupertino CA, US

Assignee:

Angiodevice International GmbH - Zug

International Classification:

A61F 13/00

US Classification:

424422

Abstract:

The present invention relates generally to synthetic polymer compositions that form interpenetrating polymer networks. In a preferred embodiment, the compositions comprise two multifunctionally activated synthetic polymers, along with a tensile strength enhancer. Such compositions form matrices that exhibit superior cohesive strength and in many instances can serve as adequate replacements for surgical means of attaching tissues, such as sutures, sponges and medical staples.

US Patent:

20050004584, Jan 6, 2005

Filed:

May 4, 2004

Appl. No.:

10/838954

Inventors:

Kenneth Franco - Omaha NB, US
George Chu - Cupertino CA, US
Frank DeLustro - Belmont CA, US
George Daniloff - Mountain View CA, US

Assignee:

Cohesion Technologies, Inc. - Palo Alto CA

International Classification:

A61B017/08

US Classification:

606155000

Abstract:

The invention relates to anastomosis stents and plugs comprised of a non-polyglycolic acid material that is resorbable by the patient in about a few minutes up to about 90 days. Such stents and plugs may be employed in surgical techniques wherein tissue is joined at an interface without need for sutures, optionally through use of a tissue sealant. As a result, interfacial tensile strengths of at least about 1.3N/cmmay be achieved.