Gene W Holbert

US Patent:

49101919, Mar 20, 1990

Filed:

Jun 28, 1988

Appl. No.:

7/212409

Inventors:

Gene W. Holbert - Loveland OH
J. O'Neal Johnston - Milford OH

Assignee:

Merrell Dow Pharmaceuticals Inc. - Cincinnati OH

International Classification:

A61K 3156
C07J 100

US Classification:

514177

Abstract:

19-Substituted progesterone derivatives and related compounds which are active as 19-hydroxylase inhibitors and useful as antihypertensive agents are described herein. The compounds are prepared using appropriate synthetic pathways which will vary according to the nature of the specific 19-substituted progesterone or related compound desired.

US Patent:

48823228, Nov 21, 1989

Filed:

Oct 27, 1988

Appl. No.:

7/263091

Inventors:

J. O'Neal Johnston - Milford OH
Gene W. Holbert - Loveland OH

Assignee:

Merrell Dow Pharmaceuticals Inc. - Cincinnati OH

International Classification:

A61K 3156
C07J 100

US Classification:

514178

Abstract:

The present invention is directed to a group of compounds which are 3. beta. ,17. beta. -hydroxy steriods, and related steroidal structures. These compounds are armatase inhibitors, and thus, regulate or inhibit the conversion of androgens to estrogens. These compounds may be utilized to treat conditions potentiated by the presence of estrogens. These compounds exhibit a slower onset of action and a longer half life relative to the 10-(2-alkynyl) steroidal aromatase inhibitors disclosed in U. S. Pat. No. 4,322,416.

US Patent:

49201140, Apr 24, 1990

Filed:

Jun 28, 1988

Appl. No.:

7/212410

Inventors:

Gene W. Holbert - Loveland OH
J. O'Neal Johnston - Milford OH

Assignee:

Merrell Dow Pharmaceuticals Inc. - Cincinnati OH

International Classification:

C07J 100
A61K 3156

US Classification:

514177

Abstract:

19-Fluoro- and cyano- substituted 21-hydroxyprogesterone derivatives and related compounds which are active as 19-hydroxylase inhibitors and useful as antihypertensive agents are described herein. The compounds are prepared using appropriate synthetic pathways which will vary according to the nature of the specific 19-substituted progesterone or related compound desired.

US Patent:

45888256, May 13, 1986

Filed:

Mar 13, 1985

Appl. No.:

6/712318

Inventors:

Joseph P. Burkhart - West Chester OH
Gene W. Holbert - Loveland OH

Assignee:

Merrell Dow Pharmaceuticals Inc. - Cincinnati OH

International Classification:

C07D30724
C07D30730
C07F 718

US Classification:

549475

Abstract:

This application relates to a stereospecific process for preparing specific enantiomers of 4-amino-4,5-dihydro-2-furancarboxylic acid and C. sub. 1-6 lower alkyl esters thereof. These compounds are. gamma. -aminobutyric acid transaminase inhibitors useful in the treatment of epilepsy.

US Patent:

49544918, Sep 4, 1990

Filed:

Jan 27, 1989

Appl. No.:

7/303367

Inventors:

J. O'Neal Johnston - Milford OH
Gene W. Holbert - Loveland OH

Assignee:

Merrell Dow Pharmaceuticals Inc. - Cincinnati OH

International Classification:

A61K 3157
C07J 900
C07J 500

US Classification:

514174

Abstract:

The present invention is directed to a method for the treatment of hyperaldosteronism and related disorders which comprises administering to an appropriate patient an appropriate 18-cyanopregnane.

US Patent:

48249742, Apr 25, 1989

Filed:

Oct 15, 1987

Appl. No.:

7/108521

Inventors:

Joseph P. Burkhart - West Chester OH
Gene W. Holbert - Loveland OH

Assignee:

Merrell Dow Pharmaceuticals Inc. - Cincinnati OH

International Classification:

C07D30730

US Classification:

549480

Abstract:

This application relates to a stereospecific process for preparing specific enantiomers of 4-amino-4,5-dihydro-2-furancarboxylic acid and C. sub. 1-6 lower alkyl esters thereof. These compounds are. gamma. -aminobutyric acid transaminase inhibitors useful in the treatment of epilepsy.