Abstract:
Disclosed herein are substituted quinazolones and their N. sup. 1 -oxide derivatives, methods of synthesizing such compounds, and methods of using them to treat or prevent convulsions in mammals. The substituted quinazolones are represented by the formula: ##STR1## wherein X. sub. 1 is N, S, O, or CH, X. sub. 2 is N or CH, R. sub. 1 and R. sub. 2 are H, NO. sub. 2, or NH. sub. 2 except that when one of R. sub. 1 and R. sub. 2 is NO. sub. 2 or NH. sub. 2 the other is H, R. sub. 3 and R. sub. 4 are alkyl with 1-5 C atoms, and R. sub. 5, R. sub. 6, and R. sub. 7 are H or halogen, provided that when X. sub. 1 is N, S, or O, X. sub. 2 is CH.