Frederick M Ausubel from 271 Lake Ave, Newton, MA 02461, age 79, Phone: 617 244-9527

Immunogenic Composition For Group B Streptococcus
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US Patent:

6342223, Jan 29, 2002
Filed:

Jul 20, 1999
Appl. No.:

09/346290
Inventors:

James L. Michel - Waban MA
Dennis L. Kasper - Newton Centre MA
Frederick M. Ausubel - Newton MA
Lawrence C. Madoff - Boston MA
Assignee:

The General Hospital Corporation Brigham and Womens Hospital - Boston MA
International Classification:

A61K 3909
US Classification:

4241901, 530350
Abstract:

A vaccine capable of protecting a recipient from infection caused by group B. The vaccine provides polysaccharide-protein moieties and contain (a) a group B polysaccharide conjugated to (b) a functional derivative of a group B C protein alpha antigen that retains the ability to elicit protective antibodies against group B. The vaccine may contain only one type of such polysaccharide-protein unit or may contain a mixture of more than one type of unit.

Virulence-Associated Nucleic Acid Sequences And Uses Thereof
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US Patent:

6355411, Mar 12, 2002
Filed:

Nov 25, 1998
Appl. No.:

09/199637
Inventors:

Frederick Ausubel - Newton MA
Howard M. Goodman - Newton MA
Laurence G. Rahme - Brookline MA
Man-Wah Tan - Somerville MA
Hui Cao - Malden MA
Eliana Drenkard - Cambridge MA
John Tsongalis - Southbridge MA
Assignee:

The General Hospital Corporation - Boston MA
International Classification:

C12Q 100
US Classification:

435 4, 530350
Abstract:

Disclosed are bacterial virulence polypeptides and nucleic acid sequences (e. g. , DNA) encoding such polypeptides, and methods for producing such polypeptides by recombinant techniques. Also provided are methods for utilizing such polypeptides to screen for antibacterial or bacteriostatic compounds.

Methods Of Screening Compounds Useful For Prevention Of Infection Or Pathogenicity
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US Patent:

6461854, Oct 8, 2002
Filed:

Mar 28, 1995
Appl. No.:

08/411560
Inventors:

Frederick M. Ausubel - Newton MA
Laurence G. Rahme - Brookline MA
Man-Wah Tan - Somerville MA
Gary B. Ruvkun - Cambridge MA
Assignee:

The General Hospital Corporation - Boston MA
International Classification:

A61K 4900
US Classification:

4352523, 424 91, 4242341, 435 4, 435 42, 435410, 435243, 43525234
Abstract:

Screening procedures are disclosed for identifying compounds useful for inhibiting infection or pathogenicity. Methods are also disclosed for identifying pathogenic virulence factors.

Broad Range Pcr Amplification Techniques
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US Patent:

6794133, Sep 21, 2004
Filed:

Jan 30, 2001
Appl. No.:

09/581106
Inventors:

Frederick M. Ausubel - Newton MA
Michael Mindrinos - Menlo Park CA
Eliana Drenkard - Cambridge MA
Assignee:

The General Hospital Corporation - Boston MA
International Classification:

C12Q 168
US Classification:

435 6, 435 912, 435 911, 435 5, 536 2433, 935 77, 935 78
Abstract:

Disclosed herein are methods and kits for determining whether a nucleic acid sequence includes a particular allele of a polymorphic sequence. These methods and kits focus on two sets of primers that are specific for an allele and are contacted with a nucleic acid sequence. One primer in each set is complementary to the polymorphic sequence at its 3â-terminal nucleotide and contains one or more mismatches in the five nucleotide adjacent to the 3â terminus. The two sets of primers preferentially amplify methods are used to identify single nucleotide polymorphisms, for example, for genomic mapping purpose.

Methods Of Screening Compounds Useful For Prevention Of Infection Or Pathogenicity
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US Patent:

6905670, Jun 14, 2005
Filed:

May 22, 2002
Appl. No.:

10/153754
Inventors:

Frederick M. Ausubel - Newton MA, US
Stephen B. Calderwood - Wellesley MA, US
Eleftherios Mylonakis - Boston MA, US
Andrew Diener - Cambridge MA, US
Julia Plotnikova - Quincy MA, US
Costi D. Sifri - Quincy MA, US
Laurence G. Rahme - Brookline MA, US
Man-Wah Tan - Somerville MA, US
Gary B. Ruvkun - Newton MA, US
Georg Jander - Ithaca NY, US
Jacqueline Heard - San Mateo CA, US
Assignee:

The General Hospital Corporation - Boston MA
International Classification:

A61K049/00
A01N063/00
A01N063/04
US Classification:

424 91, 424 931, 424 932, 424 935, 4242341, 435 4, 435 42, 435243, 4352541, 43525411, 435440, 536 231, 536 2324
Abstract:

Screening procedures are disclosed for identifying compounds useful for inhibiting fungal infection or pathogenicity. Methods are also disclosed for identifying fungal pathogenic virulence factors.

Salicylic Acid Biosynthetic Genes And Uses Thereof
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US Patent:

7070772, Jul 4, 2006
Filed:

Jul 18, 2001
Appl. No.:

09/908299
Inventors:

Mary C. Wildermuth - Cambridge MA, US
Frederick M. Ausubel - Newton MA, US
Julia Dewdney - Newton MA, US
Assignee:

The General Hospital Corporation - Boston MA
International Classification:

A01H 5/00
A01N 63/04
US Classification:

424 935, 800301
Abstract:

The invention provides methods for inducing or increasing disease resistance in a plant. The invention also features methods of using a plant having a mutation in an inducible isochorismate synthase to determine if the success of a pathogen in infecting a plant is affected by a plant disease resistance pathway involving isochorismate synthase.

Methods For Screening And Identifying Host Pathogen Defense Genes
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US Patent:

7112716, Sep 26, 2006
Filed:

Oct 18, 2001
Appl. No.:

10/042066
Inventors:

Frederick M. Ausubel - Newton MA, US
Rhonda Feinbaum - Arlington MA, US
Man Wah Tan - Palo Alto CA, US
Genviève Alloing - Nice, FR
Dennis Kim - Belmont MA, US
Assignee:

The General Hospital Corporation - Boston MA
International Classification:

A01K 67/033
US Classification:

800 8, 800 9, 424 91, 424 92
Abstract:

Disclosed are methods for identifying nematodes having enhanced susceptibility to a pathogen; for identifying pathogen defense response genes; and for identifying compounds that enhances a host's defense response to a pathogen.

Methods Of Screening Compounds Useful For Prevention Of Infection Or Pathogenicity
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US Patent:

7166270, Jan 23, 2007
Filed:

Nov 3, 1997
Appl. No.:

08/962750
Inventors:

Frederick M. Ausubel - Newton MA, US
Laurence G. Rahme - Brookline MA, US
Man-Wah Tan - Somerville MA, US
Gary B. Ruvkun - Newton MA, US
Annegien Broeks - Amsterdam, NL
Ronald H. A. Plasterk - Bussam, NL
Georg Jander - Cambridge MA, US
Jacqueline Heard - San Ramon CA, US
Assignee:

The Netherlands Cancer Institute - Amsterdam
The General Hospital Corporation - Boston MA
International Classification:

A61K 49/00
A61K 35/00
A01N 63/00
US Classification:

424 92, 424 91, 424114, 424 9347, 4242601, 435874, 536 168
Abstract:

Screening procedures are disclosed for identifying compounds useful for inhibiting infection or pathogenicity. Methods are also disclosed for identifying pathogenic virulence factors.

Short Protocols In Molecular Biology: A Compendium Of Methods From Current Protocols In Molecular Biology
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Author:

Frederick M. Ausubel
ISBN #:

0471250929

Short Protocols In Molecular Biology: A Compendium Of Methods From Current Protocols In Molecular Biology
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Author:

Frederick M. Ausubel
ISBN #:

0471514705

Short Protocols In Molecular Biology: A Compendium Of Methods From Current Protocols In Molecular Biology
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Author:

Frederick M. Ausubel
ISBN #:

0471577359