Frank Ruebsam from 7514 Charmant Dr, San Diego, CA 92122, Phone: 858 824-1798

5,6-Dihydro-1-Pyridin-2-One Compounds
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US Patent:

7582626, Sep 1, 2009
Filed:

Dec 12, 2007
Appl. No.:

11/955144
Inventors:

Chinh V. Tran - San Diego CA, US
Frank Ruebsam - San Diego CA, US
Yuefen Zhou - San Diego CA, US
Peter Dragovich - San Diego CA, US
Alan X. Xiang - San Diego CA, US
Assignee:

Anadys Pharmaceuticals, Inc. - San Diego CA
International Classification:

C07D 417/04
A61K 31/549
US Classification:

5142232, 544 12, 544 13
Abstract:

The invention is directed to 5,6-dihydro-1H-pyridin-2-one compounds of Formula I and pharmaceutical compositions containing such compounds that are useful in treating hepatitis C virus infections:.

Pyrro[1,2-]Pyridazinone Compounds
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US Patent:

7582754, Sep 1, 2009
Filed:

Nov 6, 2008
Appl. No.:

12/266190
Inventors:

Stephen E. Webber - San Diego CA, US
Frank Ruebsam - San Diego CA, US
Martin Tran - San Diego CA, US
Peter Dragovich - San Diego CA, US
Liansheng Li - San Diego CA, US
Douglas Eric Murphy - San Diego CA, US
David Kucera - Del Mar CA, US
Zhongxiang Sun - San Diego CA, US
Chinh Viet Tran - San Diego CA, US
Assignee:

Anadys Pharmaceuticals, Inc. - San Diego CA
International Classification:

C07D 513/04
A61K 31/542
A61K 31/5415
US Classification:

544 13, 5142233
Abstract:

The invention is directed to pyrro[1,2-b]pyridazinone compounds and pharmaceutical compositions containing such compounds that are useful in treating infections by hepatitis C virus.

4-Hydroxy-5,6-Dihydro-1-Pyridin-2-One Compounds
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US Patent:

7834009, Nov 16, 2010
Filed:

Aug 27, 2007
Appl. No.:

11/845515
Inventors:

David Ellis - San Diego CA, US
Liansheng Li - San Diego CA, US
Chinh V. Tran - San Diego CA, US
Frank Ruebsam - San Diego CA, US
Yuefen Zhou - San Diego CA, US
Assignee:

Anadys Pharmaceuticals, Inc. - San Diego CA
International Classification:

C07D 417/04
A61K 31/549
US Classification:

5142232, 544 12, 544 13
Abstract:

The invention is directed to 4-hydroxy-5,6-dihydro-1H-pyridin-2-one compounds of Formula I and pharmaceutical compositions containing such compounds that are useful in treating infections by hepatitis C virus:.

Pyrro[1,2-]Pyridazinone Intermediates
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US Patent:

7842838, Nov 30, 2010
Filed:

Aug 21, 2009
Appl. No.:

12/545547
Inventors:

Stephen E. Webber - San Diego CA, US
Frank Ruebsam - San Diego CA, US
Martin Tran - San Diego CA, US
Peter Dragovich - San Diego CA, US
Liansheng Li - San Diego CA, US
Douglas Eric Murphy - San Diego CA, US
David Kucera - Del Mar CA, US
Zhongxiang Sun - San Diego CA, US
Chinh Viet Tran - San Diego CA, US
Assignee:

Anadys Pharmaceuticals, Inc. - San Diego CA
International Classification:

C07C 303/00
US Classification:

564 86, 564 81
Abstract:

The invention is directed to pyrro[1,2-b]pyridazinone compounds and pharmaceutical compositions containing such compounds that are useful in treating infections by hepatitis C virus.

Oxime Glucokinase Activators
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US Patent:

7902248, Mar 8, 2011
Filed:

Dec 6, 2007
Appl. No.:

11/999670
Inventors:

Steven Joseph Berthel - Mendham Township NJ, US
Robert Francis Kester - West Orange NJ, US
Douglas Eric Murphy - San Diego NJ, US
Thomas Jay Prins - San Diego CA, US
Frank Ruebsam - San Diego CA, US
Chinh Viet Tran - San Diego CA, US
Dionisios Vourloumis - Athens, GR
Assignee:

Hoffmann-La Roche Inc. - Nutley NJ
International Classification:

A61K 31/415
A61K 31/428
C07D 231/10
C07D 277/20
US Classification:

514407, 5483561, 5483714, 5483717, 548146, 548161, 514367, 514403, 514406
Abstract:

Disclosed herein are pyrazole glucokinase activators of the formula (I):.

Pyrazole Glucokinase Activators
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US Patent:

7935699, May 3, 2011
Filed:

Jul 19, 2007
Appl. No.:

11/879935
Inventors:

Steven Joseph Berthel - Mendham Township, Morris County NJ, US
Robert Francis Kester - West Orange NJ, US
Douglas Eric Murphy - San Diego CA, US
Thomas Jay Prins - San Diego CA, US
Frank Ruebsam - San Diego CA, US
Ramakanth Sarabu - Towaco NJ, US
Chinh Viet Tran - San Diego CA, US
Dionisios Vourloumis - Athens, GR
Assignee:

Hoffmann-La Roche Inc. - Nutley NJ
International Classification:

A61K 31/5377
A61K 31/415
A61P 3/00
C07D 231/00
US Classification:

5142365, 514407, 544140, 5483725
Abstract:

Disclosed herein are pyrazole glucokinase activators of the formula (I).

5,6-Dihydro-1H-Pyridin-2-One Compounds
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US Patent:

7939524, May 10, 2011
Filed:

Apr 2, 2008
Appl. No.:

12/061499
Inventors:

Chinh V. Tran - San Diego CA, US
Frank Ruebsam - San Diego CA, US
Douglas E. Murphy - San Diego CA, US
Peter Dragovich - San Diego CA, US
Yuefen Zhou - San Diego CA, US
Lijian Chen - Encinitas CA, US
David Kucera - Del Mar CA, US
Assignee:

Anadys Pharmaceuticals, Inc. - San Diego CA
International Classification:

C07D 413/04
C07D 491/04
A61K 31/549
US Classification:

5142232, 544 12, 544 13
Abstract:

The invention is directed to 5,6-dihydro-1H-pyridin-2-one compounds of Formula I.

[1,2,4]Thiadiazine 1,1-Dioxide Compounds
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US Patent:

8097613, Jan 17, 2012
Filed:

Jun 9, 2009
Appl. No.:

12/481391
Inventors:

Frank Ruebsam - San Diego CA, US
Peter Dragovich - San Diego CA, US
Stephen E. Webber - San Diego CA, US
Douglas Eric Murphy - San Diego CA, US
Chinh Viet Tran - San Diego CA, US
Assignee:

Anadys Pharmaceuticals, Inc. - San Diego CA
International Classification:

C07D 513/04
A61K 31/542
US Classification:

5142228, 544 10, 544 12, 5142232
Abstract:

The invention is directed to [1,2,4]thiadiazine 1,1-dioxide compounds of formula I.