Cato T. Laurencin - Elkins Park PA Frank K. Ko - Philadelphia PA
Assignee:
Drexel University - Philadelphia PA
International Classification:
A61F 202
US Classification:
623 1111, 623 2374
Abstract:
Tissue engineering devices with enhanced cell adhesion, cell proliferation and directional growth are provided which are prepared from nonwoven nanofibril matrices.
Collagen Or Collagen-Like Peptide Containing Polymeric Matrices
Andrzej Fertala - Voorhees NJ Frank Ko - Philadelphia PA
Assignee:
Drexel University - Phiadelphia PA
International Classification:
A61K 3839
US Classification:
514 2, 514 21
Abstract:
Tissue engineering scaffolds comprising collagen or a collagen-like peptides incorporated within or between polymeric fibers and methods for their production are provided.
Frank K. Ko - Philadelphia PA, US Alan G. MacDiarmid - Drexel Hill PA, US Ian D. Norris - Santa Fe NM, US Manal Shaker - Pratsville AL, US Ryzard M. Lec - Philadelphia PA, US
Assignee:
Drexel University - Philadelphia PA Trustees of the University of Pennsylvania - Philadelphia PA
International Classification:
D01F 1/09 H05B 7/00
US Classification:
264465
Abstract:
A process of making conductive polymeric fibers by electrospinning fibers from a blend of polymers dissolved in an organic solvent includes generating a high voltage electric field between oppositely charged polymer fluid in a glass syringe () with a capillary tip () and a metallic collection screen () and causing a polymer jet () to flow to the screen () as solvent evaporates and collecting fibers on the screen ().
Electrospun Blends Of Natural And Synthetic Polymer Fibers As Tissue Engineering Scaffolds
Peter I. Lelkes - Cherry Hill NJ, US Mengyan Li - Philadelphia PA, US Mark Mondrinos - Philadelphia PA, US Frank Ko - Philadelphia PA, US
Assignee:
Drexel University - Philadelphia PA
International Classification:
A61K 9/70 A61K 38/39 A61F 13/00 C08G 63/08
US Classification:
424443, 424422, 530353, 530354, 528272, 514801
Abstract:
Non-woven fibrous scaffolds made by electrospinning from the synthetic biodegradable polymer such as, for example, poly(lactic-co-glycolic acid) (PLGA) and natural proteins, such as, for example, gelatin (denatured collagen) and elastin and a method of making thereof.
Ligament And Tendon Replacement Constructs And Methods For Production And Use Thereof
Cato Laurencin - Elkins Park PA, US Frank Ko - Philadelphia PA, US James Cooper - Philadelphia PA, US Helen Lu - Philadelphia PA, US Mohammed Attawia - Wayne PA, US
International Classification:
A61F002/08
US Classification:
623/013170, 623/013190
Abstract:
Degradable, polymeric fiber-based, three-dimensional braided scaffolds for use as graft materials in ligament and tendon repair, reconstruction and replacement are provided. Also provided are methods for preparing these scaffolds.
Polymeric, Fiber Matrix Delivery Systems For Bioactive Compounds
Margaret Wheatley - Media PA, US Frank Ko - Philadelphia PA, US Dalia El-Sherif - King of Prussia PA, US Nikhil Dhoot - Philadelphia PA, US Saravanan Kanakasabai - King of Prussia PA, US Meriem Benjelloun - Philadelphia PA, US Baohua Han - Lake Hiawatha NJ, US
International Classification:
A61F002/00
US Classification:
424426000, 427002210
Abstract:
Multifunctional systems for delivery of bioactive compounds incorporated within or between polymeric fibers in a matrix are provided. Also provided are methods of delivering bioactive compounds via implementation, coating and/or wrapping of these systems and methods for modulating the rate of release of bioactive compounds from these delivery systems.
Continuous Organic And Inorganic Matrix Composite Fibrils And Methods For Their Production From Carbon Nanotubes
Frank Ko - Philadelphia PA, US Asharf Ali - Zagazig, EG Amotz Geshury - Wynnewood PA, US
International Classification:
C08K003/04
US Classification:
524496000
Abstract:
Continuous nanoscale composite fibrils of carbon nanotube in a polymer matrix of polyacrylonitrile (PAN) or any other compatible polymer are provided. Methods for their production by electrospinning are also provided.
Frank Ko - Philadelphia PA, US Sachiko Sukigara - Niigata, JP Milind Gandhi - Philadelphia PA, US Jonathan Ayutsede - Philadelphia PA, US
International Classification:
B32B 9/00
US Classification:
428367000, 977904000
Abstract:
Strong and tough synthetic fibrils of carbon nanotube and spider silk are provided. Methods for production of these synthetic fibrils and methods for their use in biomedical devices, including those requiring electroconductivity, and areas of blast and ballistic protection are also provided.