Francis F Foldes

US Patent:

47342757, Mar 29, 1988

Filed:

Apr 22, 1986

Appl. No.:

6/855053

Inventors:

Iraj Lalezari - Scarsdale NY
Francis F. Foldes - Briarcliff Manor NY

Assignee:

Research Corporation - New York NY

International Classification:

A61K 3144

US Classification:

424 10

Abstract:

This invention relates to a method for antagonizing induced the neuromuscular blocking effects of certain therapeutic agents and pathological disorders in mammals, which comprises administering to said mammal an antagonizing-effective amount of a compound of the formula: ##STR1## wherein R. sub. 1 and R. sub. 2 are each hydrogen, alkyl, alkenyl, alkynyl, aryl, aralkyl, cycloalkyl, cycloalkyl-lower alkyl or hydroxyalkyl, or, when taken together, form a heterocyclic ring with the nitrogen to which they are attached, with the proviso that both are not hydrogen; R. sub. 3 is hydrogen or alkyl; and R. sub. 4 is hydrogen, alkyl, alkenyl, alkynyl, halogen or acyl; or a salt thereof with acids.

US Patent:

55917356, Jan 7, 1997

Filed:

Oct 27, 1993

Appl. No.:

8/141535

Inventors:

Zoltan Tuba - Budapest, HU
E. Szilveszter Vizi - Budapest, HU
Francis F. Foldes - Key Biscayne FL
Sandor Maho - Budapest, HU

Assignee:

Marvishi Pharmaceutical Co., Ltd. - Osaka

International Classification:

C07J 4300
A61K 3158

US Classification:

514172

Abstract:

There is disclosed novel, therapeutically active androstane derivatives having neuromuscular blocking effect, which are substituted by a quaternary ammonium group in 16-position; pharmaceutically composition containing them; process for producing them; and novel intermediates for the production.

Author:

Francis F. Foldes

ISBN #:

0387902414