Foster C Gonsalves

US Patent:

20090227624, Sep 10, 2009

Filed:

Jan 28, 2009

Appl. No.:

12/322070

Inventors:

Ramanuj Dasgupta - New York NY, US
Foster Gonsalves - Long Island City NY, US

International Classification:

A61K 31/4725
A61K 31/426
A61K 31/421

US Classification:

514307, 514365, 514374

Abstract:

A series of oxazole and thiazole compounds are shown herein to be small molecule inhibitors of the Wnt pathway that specifically target the activity of the stabilized pool of β-cat oxazole and thiazole compounds are disclosed that have a formula represented by the following:The compounds may be prepared as pharmaceutical compositions, and may be used for the prevention and treatment of a variety of conditions in mammals including humans, including by way of non-limiting example, cancer, and others.

US Patent:

20110251103, Oct 13, 2011

Filed:

Sep 10, 2009

Appl. No.:

12/998004

Inventors:

Ramanuj Dasgupta - New York NY, US
Foster Gonsalves - Long Island City NY, US

International Classification:

C40B 30/06

US Classification:

506 10

Abstract:

A novel method which integrates a “sensitized” chemical genetic high-throughput screen (HTS) with RNA interference (RNAi) screening technology is described herein. The present inventors used this method to identify specific small molecule inhibitors and activators of the Wnt pathway. More particularly, the screening method of the present invention may be used to identify small molecule inhibitors and activators that specifically target the activity of a stabilized pool of β-catenin. A number of compounds identified using the instant method, are shown herein to be small molecule inhibitors of the Wnt pathway that specifically target the activity of the stabilized pool of β-cat. The inhibitors identified by the present method may be prepared as pharmaceutical compositions, and may be used for the prevention and treatment of a variety of conditions in mammals including humans, including by way of non-limiting example, cancer, and others.

US Patent:

20120264744, Oct 18, 2012

Filed:

Apr 17, 2012

Appl. No.:

13/448737

Inventors:

Ramanuj DASGUPTA - New York NY, US
Foster GONSALVES - Brooklyn NY, US
Susan Katherine LOGAN - New York NY, US
Eugine LEE - New York NY, US

International Classification:

A61K 31/421
A61K 31/454
A61P 35/02
A61K 31/426
A61P 35/00
A61K 31/4439
A61K 31/55

US Classification:

5142171, 514374, 514340, 514326, 514369

Abstract:

A series of oxazole and thiazole compounds are shown herein to be small molecule inhibitors of the Wnt pathway that specifically target the activity of the stabilized pool of β-catenin. Oxazole and thiazole compounds are disclosed that have a formula represented by the following:The compounds may be prepared as pharmaceutical compositions, and may be used for the prevention and treatment of a variety of conditions in mammals including humans, including by way of non-limiting example, cancer, and others.

US Patent:

20130109675, May 2, 2013

Filed:

Aug 27, 2012

Appl. No.:

13/595336

Inventors:

Ramanuj Dasgupta - New York NY, US
Foster Gonsalves - Brooklyn NY, US

International Classification:

A61K 31/421
A61K 31/454
A61K 31/55
A61K 31/5377
A61K 31/496
A61K 31/427
A61K 31/422
A61K 31/506
A61K 31/4709
A61K 31/435
A61K 31/4545
A61K 31/4725
A61K 31/426
A61K 31/498
A61K 31/433
A61K 31/428
A61K 31/4439

US Classification:

5142171, 514374, 514340, 514326, 5142368, 51425402, 514371, 51425219, 514314, 514278, 514316, 514307, 5142531, 514369, 514248, 514342, 514363, 514364, 514367

Abstract:

A series of oxazole and thiazole compounds are shown herein to be small molecule inhibitors of the Wnt pathway that specifically target the activity of the stabilized pool of β-cat oxazole and thiazole compounds are disclosed that have a formula represented by the following:The compounds may be prepared as pharmaceutical compositions, and may be used for the prevention and treatment of a variety of conditions in mammals including humans, including by way of non-limiting example, cancer, and others.

US Patent:

20170066791, Mar 9, 2017

Filed:

Jan 9, 2015

Appl. No.:

15/110343

Inventors:

Eduardo J. Martinez - Bryn Mawr PA, US
Bernd Kaiser - Wallingford CT, US
Sohail F. Tavazoie - New York NY, US
Isabel Kurth - New York NY, US
Foster Casimir Gonsalves - Long Island City NY, US
Masoud Fakhr Tavazoie - New York NY, US
- New York NY, US

International Classification:

C07F 9/6571
A61K 31/165
A61K 45/06
C07C 317/04
C07C 217/18
A61K 31/24
A61K 31/138
C07D 311/76
A61K 31/366
C07C 317/14
A61K 31/145
C07B 59/00
C07F 9/09
A61K 31/661
A61K 31/675
C07D 317/46
A61K 31/357
C07C 323/09
A61K 31/195
C07D 211/96
A61K 31/445
C07D 207/48
A61K 31/40
C07D 205/04
A61K 31/397
C07C 259/06

Abstract:

This invention features compounds that modulate the activity of liver X receptors, pharmaceutical compositions including the compounds of the invention, and methods of utilizing those compositions for modulating the activity of liver X receptors in the treatment of cancer.

US Patent:

20170049751, Feb 23, 2017

Filed:

Sep 1, 2016

Appl. No.:

15/254271

Inventors:

Ramanuj DASGUPTA - New York NY, US
Foster GONSALVES - New York NY, US

International Classification:

A61K 31/421
A61K 31/4439
A61K 31/454
A61K 31/55
A61K 31/5377
A61K 31/496
A61K 31/427
A61K 31/4725
A61K 31/433
A61K 31/506
A61K 31/4709
A61K 31/435
A61K 31/426
A61K 31/498
A61K 31/5415
A61K 31/439
A61K 31/4025
A61K 31/422

Abstract:

A series of oxazole and thiazole compounds are shown herein to be small molecule inhibitors of the Wnt pathway that specifically target the activity of the stabilized pool of β-cat oxazole and thiazole compounds are disclosed that have a formula represented by the following:The compounds may be prepared as pharmaceutical compositions, and may be used for the prevention and treatment of a variety of conditions in mammals including humans, including by way of non-limiting example, cancer, and others.