Flemming Christine C Forsberg

US Patent:

58336150, Nov 10, 1998

Filed:

May 9, 1997

Appl. No.:

8/853967

Inventors:

Yunqiu Wu - Cherry Hill NJ
Flemming Forsberg - Philadelphia PA
Barry Goldberg - Conshohocken PA

Assignee:

Thomas Jefferson University - Philadelphia PA

International Classification:

A61B 800

US Classification:

600458

Abstract:

The present invention relates generally to an ultrasound system and method, and more particularly to an excitation enhanced ultrasound system and method. The system employs at least one excitation signal as a "flashlight" for exciting ultrasonic microbubbles contained in an ultrasound contrast agent. The system further employs at least one ultrasound imaging signal for imaging structures and blood flow within an object. The excitation signal excites and expands the microbubbles which increase the amount of returned ultrasound imaging signals scattered and returned by an object. This process increases the signal to noise ratio of the returning imaging signal sufficiently to provide exciter weighted imaging, blood pool imaging, and harmonic imaging, facilitating improved diagnostic ultrasound and therapeutic ultrasound.

US Patent:

6302845, Oct 16, 2001

Filed:

Mar 19, 1999

Appl. No.:

9/272764

Inventors:

William Tao Shi - Haddonfield NJ
Flemming Forsberg - Philadelphia PA
Barry B. Goldberg - Conshohocken PA
Joel S. Raichlen - Bryn Mawr PA

Assignee:

Thomas Jefferson University - Philadelphia PA

International Classification:

A61B 800

US Classification:

600438

Abstract:

The present invention relates to the use of diagnostic ultrasound and microbubble-based ultrasound contrast agents to accomplish noninvasive subharmonic aided pressure estimation (SHAPE) in the cavity of the heart, in other organs, and in major blood vessels. Diagnostic ultrasound provides noninvasive, real-time cross-sectional images and parameter estimations without ionizing radiation and without the disadvantages and risks of invasive methods of imaging and measurement. SHAPE is a non-invasive, direct, and accurate method for pressure estimation utilizing sub-harmonic or ultraharmonic signals from contrast agents. In light of the advantages of diagnostic ultrasound, SHAPE provides an economical alternative, a safe avenue, and an earlier timetable for assessing the clinical condition of patients, especially critically ill patients.

US Patent:

20220218825, Jul 14, 2022

Filed:

Mar 29, 2022

Appl. No.:

17/657028

Inventors:

- Philadelphia PA, US
Patrick O'Kane - Philadelphia PA, US
Lorenzo Albala - Philadelphia PA, US
Flemming Forsberg - Lafayette Hill PA, US

Assignee:

Drexel University - Philadelphia PA
Thomas Jefferson University - Philadelphia PA

International Classification:

A61K 41/00
A61K 49/22
A61K 33/00
A61K 9/00

Abstract:

The invention relates to an ultrasound contrast agent (UCA) comprising an outer shell and a gas core. The gas core is filled with oxygen, and the outer shell comprises a first surfactant and a second surfactant. The invention also relates to a method of making an oxygen-filled UCA and delivering oxygen to a local area of a subject's body. The method comprises injecting a composition comprising an oxygen-filled UCA of the invention into the subject's body; directing ultrasound radiation to the local area in an intensity sufficient to rupture the UCA.

US Patent:

20170056565, Mar 2, 2017

Filed:

Aug 29, 2016

Appl. No.:

15/250020

Inventors:

- Philadelphia PA, US
Steven Michael Kurtz - Philadelphia PA, US
Noreen J. Hickok - Philadelphia PA, US
Flemming Forsberg - Philadelphia PA, US
John R. Eisenbrey - Philadelphia PA, US

Assignee:

Thomas Jefferson University - Philadelphia PA
Drexel University - Philadelphia PA

International Classification:

A61L 31/14
A61B 17/70
A61M 37/00
A61L 31/06
A61L 31/16

Abstract:

An implantable medical device having a sheath formed of a polymer material, wherein the sheath forms a reservoir attached to or around the implantable medical device, and wherein the reservoir is sealed with a biocompatible pressure responsive coating; wherein the biocompatible coating is stable for at least 7-day post implantation into a body, and can be mechanically ruptured by application of an exterior pressure generating force.

US Patent:

20160059036, Mar 3, 2016

Filed:

Aug 25, 2015

Appl. No.:

14/835636

Inventors:

- Philadelphia PA, US
Patrick O'Kane - Philadelphia PA, US
Lorenzo Albala - Philadelphia PA, US
Flemming Forsberg - Lafayette Hill PA, US

International Classification:

A61N 5/10
A61K 9/50
A61K 41/00
A61K 49/22

Abstract:

The invention relates to an ultrasound contrast agent (UCA) comprising an outer shell and a gas core. The gas core is filled with oxygen, and the outer shell comprises a first surfactant and a second surfactant. The invention also relates to a method of making an oxygen-filled UCA and delivering oxygen to a local area of a subject's body. The method comprises injecting a composition comprising an oxygen-filled UCA of the invention into the subject's body; directing ultrasound radiation to the local area in an intensity sufficient to rupture the UCA.