Fernando J Muzzio

US Patent:

6910393, Jun 28, 2005

Filed:

Dec 11, 2000

Appl. No.:

10/148979

Inventors:

Fernando J. Muzzio - Monroe Township NJ, US
Albert Alexander - Somerset NJ, US
Dean Brone - Pomona NY, US
Michael Roddy - Cincinnati OH, US

Assignee:

Rutgers, The State University of New Jersey - New Brunswick NJ

International Classification:

G01N001/00

US Classification:

73863, 738644, 7386382

Abstract:

A powder sampling method and apparatus is provided for sampling powder from a mixer or a drum. An undisturbed column of powder is extracted from a vessel. The column of powder may then be sectioned into subunits, using a discharge device, providing up to dozens of samples per insertion. Larger number of representative samples of controlled size from a powder bed can be acquired.

US Patent:

7571871, Aug 11, 2009

Filed:

Nov 4, 2005

Appl. No.:

11/267039

Inventors:

Fernando J. Muzzio - Sparta NJ, US
Lev Tsygan - Brooklyn NY, US
Semen Dukler - Brooklyn NY, US

Assignee:

Rutgers, The State University of New Jersey - New Brunswick NJ

International Classification:

B02C 17/00
B02C 23/02

US Classification:

241172, 241258, 241262

Abstract:

Disclosed herein is a shear application system for applying substantially uniform amounts of shear throughout a powder sample. The shear application system preferably includes a cylinder assembly having an inner cylinder, a housing, an inner set of lugs, and an outer set of lugs. The inner cylinder has an external cylindrical surface and the housing has an internal cylindrical surface concentric with said external cylindrical surface. The internal and external cylindrical surfaces form an annular chamber therebetween. Each one of the lugs of the inner set extend radially outward from the external cylindrical surface, and each one of the lugs of the outer set extend radially inward from the internal cylindrical surface and are substantially uniformly spaced. The shear application system preferably includes drive means mechanically connected to the inner cylinder and control means electrically connected to the drive means.

US Patent:

7918410, Apr 5, 2011

Filed:

Aug 6, 2009

Appl. No.:

12/536594

Inventors:

Fernando J. Muzzio - Sparta NJ, US

Assignee:

Rutgers, The State University of New Jersey - New Brunswick NJ

International Classification:

B02C 17/00
B02C 17/16

US Classification:

241 27, 241172, 241 25

Abstract:

Disclosed herein is a shear application system for applying substantially uniform amounts of shear throughout a powder sample. The shear application system preferably includes a cylinder assembly having an inner cylinder, a housing, an inner set of lugs, and an outer set of lugs. The inner cylinder has an external cylindrical surface and the housing has an internal cylindrical surface concentric with said external cylindrical surface. The internal and external cylindrical surfaces form an annular chamber therebetween. Each one of the lugs of the inner set extend radially outward from the external cylindrical surface, and each one of the lugs of the outer set extend radially inward from the internal cylindrical surface and are substantially uniformly spaced. The shear application system preferably includes drive means mechanically connected to the inner cylinder and control means electrically connected to the drive means.

US Patent:

20130053446, Feb 28, 2013

Filed:

Nov 6, 2010

Appl. No.:

13/508485

Inventors:

Fernando J. Muzzio - Sparta NJ, US
Pavlo Takhistov - East Brunswick NJ, US
Bozena B. Michniak-Kohn - Piscataway NJ, US

Assignee:

Rutgers, The State University of New Jersey - New Brunswick NJ

International Classification:

B67D 7/06
A61K 31/137
A61K 31/192
A61P 35/00
A61P 25/00
A61P 37/08
A61P 31/18
A61P 5/00
A61P 7/02
A61P 1/00
A61P 1/16
A61P 1/06
A61P 21/02
A61P 7/10
A61P 15/00
A61P 25/22
A61P 25/06
A61P 23/00
A61P 23/02
A61P 25/20
A61P 25/08
A61P 29/00
A61P 25/26
A61P 37/00
A61P 33/00
A61P 31/00
A61P 3/02
A61K 31/18

US Classification:

514570, 514592, 514654, 222 23

Abstract:

A manufacturing device capable of creating individualized dosages of pharmaceutical preparations in which a metering system and a means of performing non-destructive chemical analysis of individual manufactured units are controlled by a microprocessor to precisely control the content and structure of each individual unit.

US Patent:

20130236511, Sep 12, 2013

Filed:

Aug 19, 2011

Appl. No.:

13/817448

Inventors:

Fernando J. Muzzio - Sparta NJ, US
Benjamin J. Glasser - Princeton NJ, US
Plamen I. Grigorov - Matawan NJ, US

Assignee:

RUTGERS, THE STATE UNIVERSITY OF NEW JERSEY - New Brunswick NJ

International Classification:

A61K 9/00

US Classification:

424400, 514629, 514570, 514415, 514567, 51425218, 5142664, 514167, 514182

Abstract:

The present invention provides methods for impregnating a porous carrier with an active pharmaceutical ingredient (“AP”), the methods comprising steps: a) dissolving at least one API in a solvent to form an API solution; b) contacting a porous carrier with the at least one API of step (a) in a contactor to form an API impregnated porous carrier; and c) drying the at least one API impregnated porous carrier.

US Patent:

59216794, Jul 13, 1999

Filed:

Jun 19, 1997

Appl. No.:

8/878896

Inventors:

Fernando J. Muzzio - Monroe NJ
David J. Lamberto - Edison NJ

Assignee:

Rutgers, the State University of New Jersey - Piscataway NJ

International Classification:

B01F 700

US Classification:

366348

Abstract:

The invention provides a method and apparatus for efficiently achieving a homogeneous mixture of fluid components by introducing said components having a Reynolds number of between about. ltoreq. 1 to about 500 into a vessel and continuously perturbing the mixing flow by altering the flow speed and mixing time until homogeniety is reached. This method prevents the components from aggregating into non-homogeneous segregated regions within said vessel during mixing and substantially reduces the time the admixed components reach homogeneity.

US Patent:

59383305, Aug 17, 1999

Filed:

Jan 5, 1998

Appl. No.:

9/003051

Inventors:

Priscilla A. Robinson - Narberth PA
Fernando J. Muzzio - Monroe NJ
Dean Brone - Green Brook NJ
Kevin Connor - Trenton NJ
Carolyn Wightman - Edison NJ

Assignee:

Merck & Co., Inc. - Rahway NJ
Rutgers, The State University of New Jersey - New Brunswick NJ

International Classification:

B01F 908

US Classification:

366224

Abstract:

A study was done to compare the performance of a conventional V-blender to a V-blender that incorporates perturbations of the particle flow by rocking the mixing vessel during its normal rotation. Mixing was investigated using glass beads with sizes from 66. mu. to 600. mu. in vessels of approximately one liter volume. Mixture uniformity was assessed qualitatively, using two different methods. One method involved a transparent mixing vessel where it was possible to see particle flow patterns and assess the state of the mixture at its surface during the entire experiment. The second method involved disposable aluminum mixing vessels, where the mixture was solidified by infiltrating the mixture with a binder. By slicing the solidified structure, it was possible to assess the entire state of the mixture including its interior structure after the completion of each experiment. Mixture uniformity was also assessed quantitatively using image analysis of the slices.

US Patent:

58849998, Mar 23, 1999

Filed:

Aug 12, 1996

Appl. No.:

8/695477

Inventors:

Fernando J. Muzzio - Monroe NJ
Richard E. Riman - Belle Mead NJ
Carolyn Wightman - Edison NJ
Paul R. Mort - Wyoming OH

Assignee:

Rutgers University - Piscataway NJ

International Classification:

B01F 902
B01F 908

US Classification:

366219

Abstract:

A method and apparatus for improved particulate mixing in which rotational motion of a mixing vessel is periodically disrupted by rocking motion. A vessel rotates around a central axis for producing the rotational motion. The vessel is rocked in a direction substantially perpendicular to the central axis for producing rocking motion. Mixing is enhanced when the rocking frequency is different than the rotational frequency.