Fei You from 21 Bouldercrest Ct, Rockville, MD 20850, age 53

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Position:

Scientist at Endocyte

Location:

Lafayette, Indiana Area

Industry:

Pharmaceuticals

Work:

Endocyte
Scientist

Education:

Brown University 1997 - 2002
PhD, Chemistry Nanjing University 1990 - 1997
BS/MS, Chemistry

Processes For Preparing Tubulysins
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US Patent:

20130137139, May 30, 2013
Filed:

Aug 5, 2011
Appl. No.:

13/814336
Inventors:

Iontcho Radoslavov Vlahov - West Lafayette IN, US
Michael Groaning - West Lafayette IN, US
Paul Joseph Kleindl - Lebanon IN, US
Hari Krishna R. Santhapuram - West Lafayette IN, US
Fei You - West Lafayette IN, US
Kevin Yu Wang - Zionsville IN, US
Katheryn Marie Stanford - Lafayette IN, US
Allen Ritter - Lafayette IN, US
Paul Christopher Leamon - West Lafayette IN, US
Assignee:

ENDOCYTE, INC. - West Lafayette US
International Classification:

C07K 5/02
US Classification:

435 681, 530330
Abstract:

Tubulysins are a series of naturally occurring cytotoxic agents that are of interest as anticancer therapeutic agents. Processes and intermediates useful for preparing naturally occurring and non-naturally occurring tubulysins and analogs and derivatives thereof are described.

Conjugates Containing Hydrophilic Spacer Linkers
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US Patent:

20140073761, Mar 13, 2014
Filed:

Mar 5, 2013
Appl. No.:

13/785542
Inventors:

Iontcho R. Vlahov - West Lafayette IN, US
Hari Krishna R. Santhapuram - West Lafayette IN, US
Paul J. Kleindl - Lebanon IN, US
Kevin Yu Wang - Zionsville IN, US
Fei You - West Lafayette IN, US
Assignee:

ENDOCYTE, INC. - West Lafayette IN
International Classification:

A61K 47/48
US Classification:

530317, 544258, 530330, 530329, 530328
Abstract:

Described herein are compositions and methods for use in targeted drug delivery using cell receptor binding drug delivery conjugates containing hydrophilic spacer linkers for use in imaging, diagnosing, and/or treating diseases and disease states caused by pathogenic cell populations.

Processes For Preparing Tubulysin Derivatives And Conjugates Thereof
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US Patent:

20140080175, Mar 20, 2014
Filed:

Mar 15, 2013
Appl. No.:

13/841349
Inventors:

Hari Krishna R. SANTHAPURAM - West Lafayette IN, US
Paul J. KLEINDL - Lebanon IN, US
Christopher P. LEAMON - West Lafayette IN, US
Fei YOU - West Lafayette IN, US
Assignee:

ENDOCYTE, INC. - West Lafayette IN
International Classification:

C07K 7/02
C07K 5/02
US Classification:

435 681, 530323, 530331
Abstract:

The invention described herein pertains to processes for preparing tubulysin derivatives, conjugates of tubulysins, and intermediates therefore.

Conjugates Containing Hydrophilic Spacer Linkers
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US Patent:

20100323973, Dec 23, 2010
Filed:

Jun 25, 2008
Appl. No.:

12/666712
Inventors:

Christopher Paul Leamon - West Lafayette IN, US
Iontcho Radoslavov Vlahov - West Lafayette IN, US
Hari Krishna R. Santhapuram - West Lafayette IN, US
Paul Joseph Kleindl - Lebanon IN, US
Yu Wang - Fishers IN, US
Fei You - West Lafayette IN, US
International Classification:

A61K 38/14
C07K 5/093
A61K 38/06
A61K 38/08
A61P 35/00
C07K 7/06
C07K 7/64
A61K 38/12
C07K 9/00
A61P 31/04
A61P 31/12
A61P 31/10
A61P 33/10
A61P 33/04
A61P 33/02
US Classification:

514 209, 530331, 514 219, 514 218, 530330, 530329, 514 217, 514 216, 530328, 530321, 514 211, 530322
Abstract:

Described herein are compositions and methods for use in targeted drug delivery using cell receptor binding drug delivery conjugates containing hydrophilic spacer linkers for use in imaging, diagnosing, and/or treating diseases and disease states caused by pathogenic cell populations.

Antifolate Conjugates For Treating Inflammation
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US Patent:

20210069340, Mar 11, 2021
Filed:

Jul 16, 2020
Appl. No.:

16/930590
Inventors:

- West Lafayette IN, US
Christopher Paul LEAMON - West Lafayette IN, US
Fei YOU - West Lafayette IN, US
Yingjuan J. LU - West Lafayette IN, US
Paul Joseph KLEINDL - Lebanon IN, US
International Classification:

A61K 47/65
A61K 47/55
C07D 487/04
C07K 7/02
C07K 9/00
C07K 5/00
C07K 5/113
C07K 19/00
C07K 7/06
A61P 19/02
A61P 29/00
A61K 31/519
Abstract:

The present invention relates to compositions and methods for use in targeted drug delivery. More particularly, the invention is directed to cell-surface receptor binding conjugates containing hydrophilic spacer linkers for use in treating disease states caused by pathogenic cell populations and to methods and pharmaceutical compositions that use and include such conjugates.

Conjugates Containing Hydrophilic Spacer Linkers
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US Patent:

20210024581, Jan 28, 2021
Filed:

Jul 2, 2020
Appl. No.:

16/919919
Inventors:

- West Lafayette IN, US
Iontcho Radoslavov Vlahov - West Lafayette IN, US
Hari Krishna R. Santhapuram - West Lafayette IN, US
Paul Joseph Kleindl - Lebanon IN, US
Kevin Yu Wang - Fishers IN, US
Fei You - West Lafayette IN, US
International Classification:

C07K 9/00
A61K 47/54
A61K 47/65
A61K 47/60
C07H 15/24
Abstract:

Described herein are compositions and methods for use in targeted drug delivery using cell receptor binding drug delivery conjugates containing hydrophilic spacer linkers for use in imaging, diagnosing, and/or treating diseases and disease states caused by pathogenic cell populations.

Pbd Conjugates For Treating Diseases
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US Patent:

20200323991, Oct 15, 2020
Filed:

Mar 29, 2017
Appl. No.:

16/088986
Inventors:

- West Lafayette IN, US
Christopher Paul LEAMON - West Lafayette IN, US
Longwu QI - San Mateo CA, US
Ning ZOU - West Lafayette IN, US
Kevin Yu WANG - Zionsville IN, US
Albert E. FELTEN - Lafayette IN, US
Garth L. PARHAM - Largo FL, US
Fei YOU - West Lafayette IN, US
Hari Krishna R. SANTHAPURAM - West Lafayette IN, US
Spencer J. HAHN - West Lafayette IN, US
Joseph Anand REDDY - West Lafayette IN, US
Yingjuan J. LU - West Lafayette IN, US
International Classification:

A61K 47/55
A61K 31/5517
Abstract:

The present disclosure relates to pyrrolobenzodiazepine (PBD) prodrugs and conjugates thereof. The present disclosure also relates to pharmaceutical compositions of the conjugates described herein, methods of making and methods of using the same.

Vitamin Receptor Drug Delivery Conjugates For Treating Inflammation
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US Patent:

20200155555, May 21, 2020
Filed:

Nov 13, 2019
Appl. No.:

16/682200
Inventors:

- West Lafayette IN, US
Iontcho Radoslavov Vlahov - West Lafayette IN, US
Yingjuan June Lu - West Lafayette IN, US
Kevin Yu Wang - Zionsville IN, US
Fei You - West Lafayette IN, US
Paul Joseph Kleindl - Lebanon IN, US
Hari Krishna R. Santhapuram - West Lafayette IN, US
International Classification:

A61K 31/519
A61K 47/55
A61K 47/54
C07K 7/06
A61K 31/436
Abstract:

Described herein are compositions, methods, compounds, conjugates, and kits for use in targeted drug delivery using drug delivery conjugates containing hydrophilic spacer linkers for use in treating disease states caused by pathogenic cell populations, such as inflammatory cells.