Fan Long from 6097 Caledonia Ct, Calabasas, CA 91377, age 52

Probe Correction For Gene Expression Level Detection
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US Patent:

7715990, May 11, 2010
Filed:

Jan 17, 2003
Appl. No.:

10/500587
Inventors:

Guangzhou Zou - San Diego CA, US
Yiping Fan - San Diego CA, US
Fan Long - Bridgewater NJ, US
Xun Wang - Chapel Hill NC, US
Tong Zhu - Chapel Hill NC, US
Assignee:

Syngenta Participations AG - Basel
International Classification:

G01N 33/483
US Classification:

702 20, 435 6
Abstract:

Individual probes on micro-arrays are re-scaled and corrected with a set of probe dependent coefficients derived from genomic-DNA hybridization signals. A dynamic range for gDNA binding is determined by measuring a concentration signal curve. Signals for each probe are measured during multiple hybridizations within a linear range. Concentration insensitive probes are then found for two sets of experiments. Probes are discarded based on a threshold compared to their standard deviation divided by their average in each set. The correction coefficients are used to calculate a corrected intensity for each probe. Probes having high uncertainty (0. 5 in one embodiment) are discarded. A weighting factor for each probe is determined along with an uncertainty factor. Finally, a call for each gene is made, such as absent, marginal or present.

Antifungal Compounds And Methods Of Use
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US Patent:

20030027243, Feb 6, 2003
Filed:

Jun 28, 2001
Appl. No.:

09/893519
Inventors:

Craig Thompson - Arlington MA, US
Jeffrey Moore - Brookline MA, US
Ed Buurman - Arlington MA, US
John Bradley - St. Louis MO, US
Thamara Desilva - Brookline MA, US
Sandra Harris - Dayton NJ, US
Svetlana Komarnitsky - Brookline MA, US
Marc Mendillo - Brighton MA, US
Daniel Moore - Medford MA, US
Melissa McCoy - Arlington MA, US
Karen Sanderson - Charlestown MA, US
Tariq Haq - Norwood MA, US
Shuhao Zhu - Waltham MA, US
Fan Long - Waltham MA, US
Eugene Davidov - Natick MA, US
Assignee:

Anadys Pharmaceuticals, Inc.
International Classification:

C12Q001/18
US Classification:

435/032000
Abstract:

The invention provides screening methods for detecting and identifying compounds that bind to fungal specific target proteins and nucleic acids, as well as compounds which, upon binding or otherwise interacting with the target protein, can inhibit fungal growth, a method of preventing or inhibiting fungal growth in culture, a method of preventing or inhibiting fungal growth in a mammal and a method of studying pathogenic mycetes using such nucleic acid and/or protein sequences. Particularly preferred is the inhibition of the fungus

Automatic Program Partition For Targeted Replay
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US Patent:

20120131559, May 24, 2012
Filed:

Nov 22, 2010
Appl. No.:

12/951253
Inventors:

Ming Wu - Beijing, CN
Fan Long - Boston MA, US
Zhilei Xu - Boston MA, US
Xuezheng Liu - Jersey City NJ, US
Haoxiang Lin - Beijing, CN
Zhenyu Guo - Beijing, CN
Zheng Zhang - Beijing, CN
Lidong Zhou - Beijing, CN
Assignee:

Microsoft Corporation - Redmond WA
International Classification:

G06F 9/44
US Classification:

717132
Abstract:

Program partitioning of an application can include creating execution flow graphs and static flow graphs of targeted functions or operations of the application. Based on the execution flow graphs or static flow graphs, replay interfaces are created. The replay interfaces provide data flows that are usable in re-execution of the application during program development.