Faizulla G Kathawala

US Patent:

40083276, Feb 15, 1977

Filed:

Jun 16, 1975

Appl. No.:

5/587345

Inventors:

Faizulla G. Kathawala - West Orange NJ

Assignee:

Sandoz, Inc. - E. Hanover NJ

International Classification:

A61K 31335

US Classification:

424278

Abstract:

The compounds are cyclic acetals of 4'-(. alpha. -hydroxy-. alpha. -alkyl-p-tolyloxy)pivalophenones, e. g. , ethylene glycol acetal of 4'-(. alpha. -hydroxy-. alpha. -heptadecyl-p-tolyloxy)pivalophenone, and are useful as anti-diabetic agents.

US Patent:

48227994, Apr 18, 1989

Filed:

Jan 27, 1988

Appl. No.:

7/149232

Inventors:

Faizulla G. Kathawala - Mountain Lakes NJ

Assignee:

Sandoz Pharm. Corp. - E. Honover NJ

International Classification:

C07D47104
A61K 31395

US Classification:

514303

Abstract:

Compounds of the formula ##STR1## and processes for and intermediates in the synthesis thereof, pharmaceutical compositions comprising such a compound and the use of such compounds for inhibiting cholesterol biosynthesis and lowering the blood cholesterol level and, therefore, in the treatment of hyperlipoproteinemia and atherosclerosis.

US Patent:

42017858, May 6, 1980

Filed:

Apr 4, 1979

Appl. No.:

6/027019

Inventors:

Faizulla G. Kathawala - Mountain Lakes NJ

Assignee:

Sandoz Inc. - Hanover NJ

International Classification:

A01N 922
A61K 3140
C09F 500
C07D20912

US Classification:

424274

Abstract:

Cyclopropanyl-group-bearing-hydrazides, e. g. cis-2-octyl-cyclopropanoctanoic acid, 2-(o-methylphenyl)-hydrazide, are useful as pharmaceutical agents and are obtainable by reacting a derivative, e. g. mixed anhydride, of a cyclopropanyl-group bearing-long chain carboxylic acid with an appropriate hydrazine.

US Patent:

42515211, Feb 17, 1981

Filed:

Feb 7, 1979

Appl. No.:

6/010014

Inventors:

Faizulla G. Kathawala - West Orange NJ

Assignee:

Sandoz, Inc. - E. Hanover NJ

International Classification:

A61K 3169
A61K 31095

US Classification:

424185

Abstract:

Alkyl diaryl sulfonium salts, e. g. , cyclopropyl diphenylsulfonium tetrafluoroborate, are useful as hypoglycemic agents.

US Patent:

40241823, May 17, 1977

Filed:

Aug 15, 1975

Appl. No.:

5/605153

Inventors:

Faizulla G. Kathawala - West Orange NJ

Assignee:

Sandoz, Inc. - E. Hanover NJ

International Classification:

C07C 5100

US Classification:

260521R

Abstract:

Aryl-butadienoic acids, e. g. , 4-(p-tetradecyloxyphenyl)-2-methyl-buta-2,3-dienoic acid, are prepared by a process comprising converting an acyl halide of an aryl lower alkanoic acid to its corresponding. beta. ,. beta. ,. beta. -trichloroethyl ester of the desired aryl-butadienoic acid which is then treated with zinc to obtain the corresponding free arylbutadienoic acid.

US Patent:

40899080, May 16, 1978

Filed:

Apr 30, 1976

Appl. No.:

5/682087

Inventors:

Faizulla G. Kathawala - West Orange NJ

Assignee:

Sandoz, Inc. - E. Hanover NJ

International Classification:

C07C 4320

US Classification:

260613D

Abstract:

The compounds are 1-aryl-1-alknyl-1-(t-butyl)-substituted methanols, e. g. 3-(2'-naphthyl)-4,4-dimethyl-pent-1-yn-3-ol, are useful as hypolipidemic agents, and are prepared by reacting a 4-aryl-pivalophenone with a metallo-alkynyl reagent under Grignard reaction conditions.

US Patent:

44566190, Jun 26, 1984

Filed:

Sep 17, 1979

Appl. No.:

6/076460

Inventors:

Faizulla G. Kathawala - Mountain Lakes NJ

Assignee:

Sandoz, Inc. - E. Hanover NJ

International Classification:

C07C103133
C07C103737
A61K 3116

US Classification:

424324

Abstract:

The compounds are secondary amides of the formula A--C. tbd. CO--NH--B wherein A is alkyl, a mono- or poly-ethylenically unsaturated acyclic hydrocarbon chain, or a hydrocarbon chain having from 1 to 4 cyclopropanyl units thereon; and B is a radical which may be of the phenyl, benzyl, phenylalkyl, benzocycloalkyl or indol- type, e. g. , N-[1-phenyl-2-(p-methylphenyl)-ethyl]-oct-2-ynoylamide. The compounds are useful as pharmaceutical agents.

US Patent:

40851494, Apr 18, 1978

Filed:

Feb 27, 1976

Appl. No.:

5/662125

Inventors:

Faizulla G. Kathawala - West Orange NJ

Assignee:

Sandoz, Inc. - E. Hanover NJ

International Classification:

C07C 4320

US Classification:

260613R

Abstract:

Hypolipidemic agents of the formula: ##STR1## wherein X is C. dbd. O or CHOH, R. degree. is branched lower alkyl, R is hydrogen, alkyl, or halo, n is 1 or 2, and R' and R" are hydrogen, halo, alkyl or alkoxy, e. g. , 4-phenoxy-pivalophenone.