Fabrice D Gallou from Paris, TX, age 49

Stereoselective Synthesis Of Certain Trifluoromethyl-Substituted Alcohols
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US Patent:

7179919, Feb 20, 2007
Filed:

Mar 2, 2005
Appl. No.:

11/070462
Inventors:

Jinhua J. Song - Hopewell Junction NY, US
Zhulin Tan - Danbury CT, US
Nathan K. Yee - Danbury CT, US
Chris Hugh Senanayake - Brookfield CT, US
Jinghua Xu - Bethel CT, US
Fabrice Gallou - Danbury CT, US
Assignee:

Boehringer Ingelheim Pharmaceuticals, Inc. - Ridgefield CT
International Classification:

C07D 471/04
US Classification:

546113
Abstract:

A process for stereoselective synthesis of a compound of Formula (I).

Ring-Closing Metathesis Process In Supercritical Fluid
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US Patent:

7189844, Mar 13, 2007
Filed:

Sep 9, 2005
Appl. No.:

11/222882
Inventors:

Fabrice Gallou - Danbury CT, US
Nathan Yee - Danbury CT, US
Assignee:

Boehringer Ingelheim International GmbH - Ingelheim
International Classification:

C07D 245/00
US Classification:

540460
Abstract:

Disclosed is a process for preparing a compound of formula I comprising cyclizing a diene compound of formula III in the presence of a ruthenium catalyst in a suitable organic solvent, wherein the process is performed in a gaseous fluid at supercritical or near-supercritical conditions:.

Process For Preparing Macrocyclic Hcv Protease Inhibitors
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US Patent:

7375218, May 20, 2008
Filed:

Sep 9, 2005
Appl. No.:

11/222950
Inventors:

Fabrice Gallou - Danbury CT, US
Assignee:

Boehringer Ingelheim International GmbH - Ingelheim
International Classification:

C07D 215/16
C07K 5/08
US Classification:

540456, 546153
Abstract:

Disclosed are highly convergent processes for preparing compounds of formula (I), which compounds are potent active agents for the treatment of hepatitis C virus (HCV) infection:.

Removal Of Ruthenium By-Product By Supercritical Fluid Processing
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US Patent:

7268211, Sep 11, 2007
Filed:

Dec 7, 2004
Appl. No.:

11/006475
Inventors:

Fabrice Gallou - Danbury CT, US
Said Saim - New Milford CT, US
Nathan K. Yee - Danbury CT, US
Assignee:

Boehringer Ingelheim International GmbH - Ingelheim
International Classification:

C07K 5/12
C07D 245/00
C07F 15/00
US Classification:

530317, 556 21, 556 22, 548101, 540460, 34329, 34337, 570190, 570211
Abstract:

A process for removing ruthenium or ruthenium-containing compounds from a reaction mixture comprising a compound of the following formula I in an organic solvent using supercritical fluid processing techniques:.

Process For Preparing Macrocyclic Compounds
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US Patent:

20050049187, Mar 3, 2005
Filed:

Apr 6, 2004
Appl. No.:

10/818657
Inventors:

Joerg Brandenburg - Wiesbaden, DE
Kai Donsbach - Glen Allen VA, US
Hans-Dieter Ecker - Gau-Algesheim, DE
Rogelio Frutos - Sandy Hook CT, US
Fabrice Gallou - Danbury CT, US
Dieter Gutheil - Bad Kreuznach, DE
Nizar Haddad - Danbury CT, US
Robert Hagenkoetter - Idstein, DE
Dirk Kemmer - Guldental, DE
Jutta Kroeber - Bingen-Dietersheim, DE
Thomas Nicola - Ingelheim, DE
Juergen Schnaubelt - Biberach, DE
Michael Schul - Plaidt, DE
Robert Simpson - Wilmington DE, US
Xudong Wei - Ridgefield CT, US
Eric Winter - Gau-Algesheim, DE
Yibo Xu - New Milford CT, US
Nathan Yee - Danbury CT, US
Assignee:

Boehringer Ingelheim International GmbH - Ingelheim
International Classification:

A61K038/12
A61K031/4709
C07K005/12
US Classification:

514009000, 530317000, 514312000
Abstract:

Disclosed is a process for preparing a macrocyclic compound of the formula (I): which is carried out using an intermediate of the formula (II): wherein W, Rthrough R, D, A and Rare as defined herein. The compounds of formula (I) are potent active agents for the treatment of hepatitis C virus (HCV) infection.

Process For Preparing Macrocyclic Compounds
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US Patent:

20050209135, Sep 22, 2005
Filed:

Mar 11, 2005
Appl. No.:

11/078074
Inventors:

Carl Busacca - Poughkeepsie NY, US
Vittorio Farina - Ridgefield CT, US
Fabrice Gallou - Danbury CT, US
Nizar Haddad - Danbury CT, US
Xiao-Jun Wang - Danbury CT, US
Xudong Wei - Ridgefield CT, US
Jinghua Xu - Bethel CT, US
Yibo Xu - New Milford CT, US
Nathan Yee - Danbury CT, US
Li Zhang - New Milford CT, US
Assignee:

Boehringer Ingelheim International GmbH - Ingelheim
International Classification:

A61K038/12
A61K031/4709
C07K005/12
US Classification:

514010000, 514314000, 530317000, 540465000
Abstract:

Disclosed is a multi-step process for preparing a macrocyclic compound of the formula (I): wherein Q is a radical of the following formula: and the other variables are as defined herein. The compounds of formula (I) are potent active agents for the treatment of hepatitis C virus (HCV) infection.

Fabrice D Gallou