Esmaiel M Jabbari from 47 Dorchester St APT 11, Boston, MA 02127, age 63

Us Patents

Hydroxyapatite Grafted Fumarate Based Macromers For Biodegradable Composites
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US Patent:

7642300, Jan 5, 2010
Filed:

Jun 29, 2004
Appl. No.:

10/562591
Inventors:

Michael J. Yaszemski - Rochester MN, US
Bradford L. Currier - Rochester MN, US
Esmaiel Jabbari - Columbia SC, US
Lichun Lu - Rochester MN, US
International Classification:

C08F 297/02
C08F 297/00
US Classification:

523113, 523114, 523115, 523116, 424424
Abstract:

A composition is disclosed which comprises (i) a macromer prepared by reacting an unsaturated diacid having a carbon-carbon double bond and a saturated diacid, and (ii) a bioactive ceramic grafted to the macromer. In one embodiment, the unsaturated diacid having a carbon-carbon double bond is fumaric acid, the saturated diacid is compatible with fumaric acid and poly(propylene fumarate) such as succinic acid, glutaric acid, adipic acid, pimelic acid, suberic acid, azelaic acid, sebacic acid and mixtures thereof, and the bioactive ceramic is hydroxyapatite. In another embodiment, hydroxyapatite is grafted with a biodegradable and crosslinkable macromer comprising silane units alternating with furnarate and adipate units.

Self-Crosslinkable Poly(Caprolactone Fumarate)
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US Patent:

20070043202, Feb 22, 2007
Filed:

Jun 29, 2004
Appl. No.:

10/562777
Inventors:

Michael Yaszemski - Rochester MN, US
Bradford Currier - Rochester MN, US
Esmaiel Jabbari - Columbia SC, US
Lichun Lu - Rochester MN, US
International Classification:

C08G 69/08
US Classification:

528310000
Abstract:

Fumaric acid or a salt thereof, such as a fumaryl halide (e.g., fumaryl chloride), which contains unsaturated carbon-carbon double bonds that can be used for in situ crosslinking, is copolymerized with a biodegradable poly(caprolactone) macromer that has a flexible backbone such that the resulting copolymer may self-crosslink in the absence of a crosslinking agent. The bio-compatible and bioresorbable poly(caprolactone fumarate) biomaterial is useful in the fabrication of injectable and in-situ hardening scaffolds for application in skeletal reconstruction.

Bioresorbable Composition For Repairing Skeletal Tissue
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US Patent:

20090110732, Apr 30, 2009
Filed:

Jul 12, 2006
Appl. No.:

11/995612
Inventors:

Esmaiel Jabbari - Columbia SC, US
International Classification:

A61K 9/10
A61K 31/74
A61K 9/14
US Classification:

424486, 424 7808, 424501, 977773
Abstract:

Bioresorbable compositions for treating skeletal tissue are disclosed. The biomedical compositions are formed from a polylactide polymer, a polyglycolide polymer, or a poly(lactic-co-glycolic acid) polymer having a relatively low molecular weight. For instance, the average number molecular weight of the polymer is generally less than 10,000, such as from about 500 to about 5,000. Fumarate groups are incorporated into the low molecular weight polymer that provide crosslinking sites. If desired, ethylene oxide groups and ceramic particles may also be incorporated into the polymer for producing compositions having a variety of properties. For example, the biomedical composition of the present disclosure can be used to treat soft skeletal tissue or to treat hard skeletal tissue. The biomedical compositions are biodegradable and can contain various therapeutic, beneficial and pharmaceutical agents that may be released during degradation of the polymer.

Fabrication Of Biomimetic Scaffolds With Well-Defined Pore Geometry By Fused Deposition Modeling
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US Patent:

20100084784, Apr 8, 2010
Filed:

Oct 8, 2009
Appl. No.:

12/575867
Inventors:

Esmaiel Jabbari - Columbia SC, US
Assignee:

UNIVERSITY OF SOUTH CAROLINA - Columbia SC
International Classification:

B29C 33/38
US Classification:

264219
Abstract:

A method for fabrication of a scaffold by fused deposition modeling is provided. The method includes forming a sacrificial mold with fused deposition modeling, the sacrificial mold comprising a dissolvable material. The method further includes infusing the sacrificial mold with a biodegradable composition and applying a solvent to the biodegradable composition infused sacrificial mold to dissolve the sacrificial mold and leave a scaffold formed from the biodegradable composition.

Self-Assembled Biodegradable Nanoparticles For Medical And Biological Applications
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US Patent:

20100086607, Apr 8, 2010
Filed:

Oct 8, 2009
Appl. No.:

12/575876
Inventors:

Esmaiel Jabbari - Columbia SC, US
Assignee:

UNIVERSITY OF SOUTH CAROLINA - Columbia SC
International Classification:

A61K 9/14
C08F 8/30
C08L 1/00
A61K 47/48
US Classification:

424489, 525375, 514 2, 977773, 977906
Abstract:

A method for forming a biodegradable composition that self-assembles into nanoparticles is provided. The method includes reacting N,N′-Disuccinimidyl carbonate with hydroxyl end-groups of poly(lactide-co-fumarate) to form a composition comprising succinimide-terminated poly(lactide-co-fumarate).

Peptidomimetic Resorbable Peptide-Polymer Hybrid Polyester Nanoparticles
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US Patent:

20100322979, Dec 23, 2010
Filed:

Jun 22, 2010
Appl. No.:

12/820683
Inventors:

Esmaiel Jabbari - Columbia SC, US
Assignee:

UNIVERSITY OF SOUTH CAROLINA - Columbia SC
International Classification:

A61K 9/14
A61P 35/00
A61K 31/337
B32B 1/00
US Classification:

424400, 514449, 428402, 424497, 977773
Abstract:

In accordance with certain embodiments of the present disclosure, a self-assembling biodegradable nanoparticle is provided. The nanoparticle includes a degradable synthetic polymer chain, a sequence of non-polar amino acids, and a sequence of ionic amino acids. The nanoparticle has a diameter of from about 50 nm to about 150 nm.

Electrospun Fibrous Three-Dimensional Scaffolds With Well-Defined Pore Geometry
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US Patent:

20100327494, Dec 30, 2010
Filed:

Jun 22, 2010
Appl. No.:

12/820691
Inventors:

Esmaiel Jabbari - Columbia SC, US
Assignee:

UNIVERSITY OF SOUTH CAROLINA - Columbia SC
International Classification:

B29C 47/36
US Classification:

264466
Abstract:

In accordance with certain embodiments of the present disclosure, a method for fabricating multi-layer fibrous scaffolds with a well-defined pore geometry is provided. The method includes electrospinning generally parallel rows of biodegradable synthetic polymer fibers onto a collector plate, wherein the fibers of each generally parallel row on the collector plate are generally aligned as they are electrospun onto the collector plate. The collector plate is rotated and additional generally parallel rows of biodegradable synthetic polymer fibers are electrospun onto the collector plate, wherein the additional fibers on the collector plate are generally aligned as they are electrospun onto the collector plate and a multi-layer scaffold is formed. The process can be continued to form a multi-layer fibrous scaffold with macropores of well-defined geometry.

Fiber-Reinforced Laminated Hydrogel / Hydroxyapatite Nanocomposites
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US Patent:

20120226295, Sep 6, 2012
Filed:

Jun 22, 2010
Appl. No.:

12/820701
Inventors:

Esmaiel Jabbari - Columbia SC, US
Assignee:

UNIVERSITY OF SOUTH CAROLINA - Columbia SC
International Classification:

A61L 27/52
B29C 70/18
B82Y 40/00
US Classification:

606151, 156324, 977961
Abstract:

In accordance with certain embodiments of the present disclosure, a method for forming a laminated nanocomposite is provided. The method includes applying a hydrogel precursor solution to a first layer of poly(L-lactide) nanofiber mesh. A second layer of poly(L-lactide) nanofiber mesh is stacked on the first layer with at least a portion of the hydrogel precursor solution being situated between the first layer and the second layer. The method further includes compressing the first layer and second layer together wherein the first layer and second layer are crosslinked to one another by the hydrogel precursor solution to form a laminated nanocomposite. Furthermore, the laminate layers, prior to crosslinking, can be wrapped around a rod and crosslinked to form a laminated tubular nanocomposite.