Ernest J Tickner

US Patent:

46577564, Apr 14, 1987

Filed:

Sep 8, 1983

Appl. No.:

6/530301

Inventors:

Julia S. Rasor - Cupertino CA
Ernest G. Tickner - Gilroy CA

Assignee:

Schering Aktiengesellschaft - Berlin and Bergkamen

International Classification:

A61K 4900
A61B 1000

US Classification:

424 9

Abstract:

Microbubbles are formed in a liquid, e. g. , blood in order to alter the transmission characteristics thereof to electromagnetic and sonic waves transmitted therethrough, by dissolving therein a solid particulate material, preferably as a suspension in a carrier liquid in which the particulate material is at least temporarily stable, the particles of which are substantially free of microbubbles and have a plurality of gas-filled voids communicating with the surface of the particles and providing nuclei for microbubble formation and the ratio of the mass of the particles to the volume of gas in the voids is sufficient to render the liquid in which the particulate material is dissolved supersaturated with respect to the gas in the voids in the area of the liquid surrounding the microbubbles when they are formed.

US Patent:

43163912, Feb 23, 1982

Filed:

Nov 13, 1979

Appl. No.:

6/093525

Inventors:

Ernest G. Tickner - Gilroy CA

Assignee:

Ultra Med, Inc. - Sunnyvale CA

International Classification:

G01F 100

US Classification:

7386125

Abstract:

A method is presented for measuring fluid flow rate in a system having a conduit through which the fluid flows. The method is particularly useful for measuring blood flow rate in a cardiovascular system. A substance which provides a plurality of microbubbles is added to the fluid flow system upstream of the measurement position in the conduit. An ultrasonic pulse is generated from a position opposite and spaced from the conduit as the microbubbles pass therethrough. A reflected ultrasonic image, created by reflection of the pulse from at least the wall of the conduit which is distal from said position, is measured. The fluid flow rate within the conduit is determined from these ultrasonic images using dye dilution techniques. In a living being, the pulse is preferably generated adjacent the rib cage or in the esophagus and the conduit is preferably the heart or the pulmonary artery, whereby, the blood flow rate determined is equal to the volumetric cardiac output rate.

US Patent:

42768853, Jul 7, 1981

Filed:

May 4, 1979

Appl. No.:

6/036098

Inventors:

Ernest G. Tickner - Morgan Hill CA
Ned S. Rasor - Santa Clara County CA

Assignee:

Rasor Associates, Inc - Sunnyvale CA

International Classification:

A61B 1000

US Classification:

128660

Abstract:

Ultrasonic images of flowing streams can provide important information regarding the streams. Herein, a plurality of microbubbles are provided in such streams to enhance such images, aid in tumor detection and treatment, provide mapping of vascularity of tissue masses and measure instantaneous blood flow rate. The preferred microbubbles have a coalescence resistant surface membrane encapsulating a gas of a selected composition, the membrane including non-toxic and non-antigenic organic molecules. Preferrably, the microbubbles have diameters in the 0. 5 micron-300 micron range.

US Patent:

46811192, Jul 21, 1987

Filed:

Apr 22, 1986

Appl. No.:

6/854622

Inventors:

Julia S. Rasor - Cupertino CA
Ernest G. Tickner - Gilroy CA

Assignee:

Schering Aktiengesellschaft - Berlin and Bergkamen

International Classification:

A61B 1000

US Classification:

128660

Abstract:

In the inventive method, microbubbles are formed in body liquid or carrier liquid, for example within the genitourinary or digestive systems in order to alter the transmission characteristics thereof to electromagnetic and sonic waves transmitted therethrough, by dissolving therein a solid particulate material, preferably as a suspension in a carrier liquid in which the particulate material is at least temporarily stable, the particles of which are substantially free of microbubbles and have a plurality of gas-filled voids communicating with the surface of the particles and providing nuclei for microbubble formation and the ratio of the mass of the particles to the volume of gas in the voids is sufficient to render the liquid in which the particulate material is dissolved supersaturated with respect to the gas in the voids in the area of the liquid surrounding the microbubbles when they are formed.

US Patent:

42652510, May 5, 1981

Filed:

Jun 28, 1979

Appl. No.:

6/052745

Inventors:

Ernest G. Tickner - Morgan Hill CA

Assignee:

Rasor Associates, Inc. - Sunnyvale CA

International Classification:

A61B 502

US Classification:

128660

Abstract:

Pressure within a liquid containing vessel is determined by adding a solid precursor for at least one bubble to the liquid, retaining the precursor in the liquid for a sufficient time for it to form at least one bubble and generate a sonic signal, metering a characteristic of the sonic signal which is representative of the pressure in the liquid and determining the pressure in the liquid from the measured characteristic.

US Patent:

44428430, Apr 17, 1984

Filed:

Nov 17, 1981

Appl. No.:

6/322138

Inventors:

Julia S. Rasor - Cupertino CA
Ernest G. Tickner - Gilroy CA

Assignee:

Schering, AG - Berlin

International Classification:

A61G 1000

US Classification:

128660

Abstract:

Microbubbles are formed in a liquid, e. g. , blood in order to alter the transmission characteristics thereof to electromagnetic and sonic waves transmitted therethrough, by dissolving therein a solid particulate material, preferably as a suspension in a carrier liquid in which the particulate material is at least temporarily stable, the particles of which are substantially free of microbubbles and have a plurality of gas-filled voids communicating with the surface of the particles and providing nuclei for microbubble formation and the ratio of the mass of the particles to the volume of gas in the voids is sufficient to render the liquid in which the particulate material is dissolved supersaturated with respect to the gas in the voids in the area of the liquid surrounding the microbubbles when they are formed.

US Patent:

39956210, Dec 7, 1976

Filed:

Jan 27, 1976

Appl. No.:

5/652948

Inventors:

James C. Administrator of the National Aeronautics and Space Fletcher
William Elkins - San Jose CA
Bill Alvin Williams - Morgan Hill CA
Ernest Glenn Tickner - Mountain View CA

International Classification:

A61B 506
A61F 700

US Classification:

128 2H

Abstract:

A device for enhancing the detection of malignant tissue in the breasts of a woman comprises a brassiere-like garment which is fitted with a pair of liquid-perfused cooling panels which completely and compliantly cover the breasts and upper torso. The garment is connected by plastic tubing to a liquid cooling system comprising a fluid pump, a solenoid control valve for controlling the flow of fluid to either the cooling unit or the heating unit, a fluid reservoir, a temperature sensor in the reservoir, and a restrictor valve to control the pressure in the garment inlet cooling line.