Erin G Carruthers

US Patent:

20170233787, Aug 17, 2017

Filed:

Aug 4, 2015

Appl. No.:

15/501807

Inventors:

- Franklin Lakes NJ, US
Adam Curry - Raleigh NC, US
Kara Birchfield - Raleigh NC, US
Kristin Weidemaier - Raleigh NC, US
Erin Carruthers - Raleigh NC, US

International Classification:

C12Q 1/32
G01N 33/569

Abstract:

Methods and compositions for the detection of glucose-6-phosphate dehydrogenase (G6PD) enzyme activity in blood samples are described. Some embodiments disclosed herein provide methods for detecting G6PD activity in undiluted or minimally diluted blood samples, including obtaining a blood sample, and detecting G6PD activity present in the undiluted or minimally diluted blood sample by epifluorescence. Also provided are methods for detecting G6PD activity and detecting a bloodborne microorganism as two parts of a single test.

US Patent:

20150118688, Apr 30, 2015

Filed:

Mar 15, 2013

Appl. No.:

14/391340

Inventors:

- Franklin Lakes NJ, US
Robert L. Campbell - Bullock NC, US
Erin Gooch Carruthers - Cary NC, US
Adam C. Curry - Raleigh NC, US
Kevin G. Dolan - Holly Springs NC, US
Andrea Liebmann-Vinson - Wake Forest NC, US
Wendy Dale Woodley - Cary NC, US
Melody M.H. Kuroda - Durham NC, US
Ammon David Lentz - York PA, US
Dwight Livingston - Fallston MD, US
Michael Justin Lizzi - Stewartstown PA, US
Artis R. Lockhart - Durham NC, US
Ernie Ritchey - Middle River MD, US
Eric A. Fallows - Apex NC, US
Donald E. Gorelick - Nashua NH, US
Jack Kessler - Southborough MA, US
Spencer Lovette - Mount Vernon NH, US
Jeffrey S. Ojala - Candia NH, US
Mark A. Talmer - Pepperell MA, US
Miroslaw Bartkowiak - Raleigh NC, US
Scott N. Danhof - Plain City OH, US
Gregory S. Kramer - Hilliard OH, US
Thomas D. Haubert - Columbus OH, US
Michael L. Marshall - Lewis Center OH, US
James A. Prescott - Columbus OH, US
Randy J. Somerville - Columbus OH, US
M. Scott Ulrich - Columbus OH, US
David S. Sebba - Cary NC, US

International Classification:

G01N 33/543
B01L 3/02
B01L 3/00

US Classification:

435 71, 422501, 422558, 422522, 4352873

Abstract:

Provided herein are methods, systems, and devices for detecting and/or identifying one or more specific microorganisms in a culture sample. Indicator particles, such as surface enhanced Raman spectroscopy (SERS)-active nanoparticles, each having associated therewith one or more specific binding members having an affinity for the one or more microorganisms of interest, can form a complex with specific microorganisms in the culture sample. Further, agitating magnetic capture particles also having associated therewith one or more specific binding members having an affinity for the one or more microorganisms of interest can be used to capture the microorganism-indicator particle complex and concentrate the complex in a localized area of an assay vessel for subsequent detection and identification. The complex can be dispersed, pelleted, and redispersed so that the culture sample can be retested a number of times during incubation so as to allow for real-time monitoring of the culture sample.