Dual Acting Pharmaceutical Compositions Based On Superstructures Of Angiotensin Receptor Antagonist/Blocker (Arb) And Ne Utral Endopeptidase (Ep) Inhibitor
Suliman Al-Fayoumi - Morristown NJ, US Jiahui Hu - Bridgewater NJ, US Natrajan Kumaraperumal - Wayne NJ, US Alan E. Royce - Saylorsburg PA, US Colleen Ruegger - Morris Plains NJ, US Erika A. Zannou - Edison NJ, US
International Classification:
A61K 31/41 A61P 9/12 A61P 9/10
US Classification:
514381
Abstract:
Solid oral dosage forms, especially tablets, of a pharmaceutical composition comprising a supramolecular complex can be formed from a direct compression process or a compaction process such as roller compaction. Such solid oral dosage forms feature an immediate release profile that allows for fast release of the therapeutic agent. A particularly useful supramolecular complex is trisodium [3-((1S,3R)-1-biphenyl-4-ylmethyl-3-ethoxycarbonyl-1-butylcarbamoyl)propionate-(S)-3′-methyl-2′-(pentanoyl{2″-(tetrazol-5-ylate)biphenyl-4′-ylmethyl}amino)butyrate]hemipentahydrate.
Erika Zannou - Edison NJ, US Simon Bateman - Randolph NJ, US Madhusudhan Pudipeddi - Edison NJ, US Alan Royce - Saylorsburg PA, US Abu Serajuddin - Queens NY, US
Assignee:
NOVARTIS AG - Basel
International Classification:
A61K 9/20 A61K 31/66
US Classification:
424464000, 514102000
Abstract:
A pharmaceutical formulation comprising an oral dosage form containing a bisphosphonic acid or a salt thereof and an inactive ingredient selected from: an ester of a medium chain fatty acid, or a lipophilic polyethylene glycol ester, said inactive ingredient having a hydrophilic lipophilic balance (HLB) of from about 1 to about 30.
Dual-Acting Pharmaceutical Compositions Based On Superstructures Of Angiotensin Receptor Antagonist/Blocker (Arb) And Neutral Endopeptidase (Nep) Inhibitor
- Basel, CH Jiahui HU - Bridgewater NJ, US Natrajan KUMARAPERUMAL - Wayne NJ, US Alan E. ROYCE - Saylorsburg PA, US Colleen RUEGGER - Morris Plains NJ, US Erika A. ZANNOU - Edison NJ, US
International Classification:
A61K 31/216 A61K 9/20 A61K 31/41
Abstract:
Solid oral dosage forms, especially tablets, of a pharmaceutical composition comprising a supramolecular complex can be formed from a direct compression process or a compaction process such as roller compaction. Such solid oral dosage forms feature an immediate release profile that allows for fast release of the therapeutic agent. A particularly useful supramolecular complex is trisodium [3-((1S,3R)-1-biphenyl-4-ylmethyl-3-ethoxycarbonyl-1-butylcarbamoyl) propionate-(S)-3′-methyl-2′-(pentanoyl{2″-(tetrazol-5-ylate)biphenyl-4′-ylmethyl}amino)butyrate]hemipentahydrate.
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