Eric Wehrenberg-Klee

US Patent:

20050265928, Dec 1, 2005

Filed:

May 9, 2005

Appl. No.:

11/125010

Inventors:

David Edwards - Boston MA, US
Jean Sung - Cambridge MA, US
Brian Pulliam - Brookline MA, US
Eric Wehrenberg-Klee - Palo Alto CA, US
Evan Schwartz - Tamarac FL, US
Philip Dreyfuss - Wynnewood PA, US
Sandeep Kulkarni - San Diego CA, US
Erez Lieberman - Cambridge MA, US

International Classification:

A61K039/015
A61L009/04
A61K009/14

US Classification:

424046000, 424272100

Abstract:

Particulate compositions for delivery, preferably pulmonary, which provide sustained release of antigens, preferably DNA and/or peptide and/or protein antigens, have been developed. In the preferred embodiment, aggregate nanoparticles are in the aerodynamic range of 1-5 microns diameter and fly deep into the lungs. As the aggregate particles degrade in the body, MSP-1 and AMA-1 proteins are released into the blood stimulating a humoural immune response. The individual particles in the range of 0.1 micron are preferentially phagocytosed by APCs which express the proteins encoded by AMA-1 and MSP-1 plasmid DNA thereby initiating the cellular immune response that is necessary for a complete immunity.

US Patent:

20190224348, Jul 25, 2019

Filed:

Jun 30, 2017

Appl. No.:

16/314134

Inventors:

- Boston MA, US
Benjamin Larimer - Woburn MA, US
Eric Wehrenberg-Klee - Boston MA, US

International Classification:

A61K 51/08
A61K 51/04
A61P 35/00
A61K 51/10

Abstract:

Provided herein are compounds useful for imaging granzyme B. An exemplary compound provided herein is useful as a radiotracer for position emission tomography (PET) and/or single photon emission tomography (SPECT) imaging. Methods of imaging granzyme B, combination therapies, and kits comprising the granzyme B imaging agents are also provided.