Paul F. Jackson - Bel Air MD Keith M. Maclin - Baltimore MD Eric Wang - Baltimore MD Barbara S. Slusher - Kingsville MD Rena S. Lapidus - Baltimore MD Pavel Majer - Sykesville MD
Assignee:
Guilford Pharmaceutical Inc. - Baltimore MD
International Classification:
A61K 3166
US Classification:
514 75, 514143, 514277, 514574
Abstract:
The present invention relates to N-Acetylated -Linked Acidic Dipeptidase (NAALADase) inhibitors enzyme activity, pharmaceutical compositions comprising such inhibitors, and methods of their use to inhibit NAALADase enzyme activity, thereby effecting neuronal activities, inhibiting angiogenesis, and treating glutamate abnormalities, compulsive disorders, prostate diseases, pain and diabetic neuropathy.
Symmetrically Disubstituted Aromatic Compounds And Pharmaceutical Compositions For Inhibiting Poly (Adp-Ribose) Glycohydrolase, And Methods For Their Use
Jia-He Li - Cockeysville MD Dana Victor Ferraris - Towson MD Paul W. Kletzly - Arlington VA Weixing Li - Ellicott City MD Eric Yanjun Wang - Ellicott City MD Amy D. Xing - Ellicott City MD Weizheng Xu - Ellicott City MD Jie Zhang - Ellicott City MD
Assignee:
Guilford Pharmaceuticals, Inc. - Baltimore MD
International Classification:
C07C23300
US Classification:
564158, 544386, 544387, 514255, 514617, 514621
Abstract:
Symmetrically disubstituted aromatic compounds and pharmaceutical compositions containing such compounds that inhibit and/or modulate the activity of poly(ADP-ribose) glycohydrolase, also known as PARG, are described. The invention is also directed to the therapeutic or prophylactic use of such compounds and compositions, and to methods of treating diseases and disorders described herein, by administering effective amounts of such compounds.
Compounds And Compositions For Delivering Active Agents
Amino acid derivative as carrier compounds and compositions which are useful in the delivery of active agents are provided. The active agents can be a peptide, mucopolysaccharide, carbohydrate, or lipid. Methods of administration, including oral administration, and preparation are provided as well.
Naaladase Inhibitors Useful As Pharmaceutical Compounds And Compositions
Paul Jackson - Bel Air MD, US Keith Maclin - Baltimore MD, US Eric Wang - Baltimore MD, US Barbara Slusher - Kingsville MD, US Rena Lapidus - Baltimore MD, US Pavel Majer - Sykesville MD, US
International Classification:
A61K031/21 C07C329/06
US Classification:
514/513000, 514/561000, 514/562000, 558/236000
Abstract:
The present invention relates to N-Acetylated -Linked Acidic Dipeptidase (NAALADase) inhibitors enzyme activity, pharmaceutical compositions comprising such inhibitors, and methods of their use to inhibit NAALADase enzyme activity, thereby effecting neuronal activities, inhibiting angiogenesis, and treating glutamate abnormalities, compulsive disorders, prostate diseases, pain and diabetic neuropathy.
Symmetrically Disubstituted Aromatic Compounds And Pharmaceutical Compositions For Inhibiting Poly (Adp-Ribose) Glycohydrolase, And Methods For Their Use
Jia-He Li - Cockeysville MD, US Dana Ferraris - Towson MD, US Paul Kletzly - Arlington VA, US Weixing Li - Ellicott City MD, US Eric Wang - Ellicott City MD, US Amy Xing - Ellicott City MD, US Weizheng Xu - Ellicott City MD, US Jie Zhang - Ellicott City MD, US
Assignee:
Guilford Pharmaceuticals, Inc. - Baltimore MD
International Classification:
C07C069/76 A61K031/235
US Classification:
514/532000, 560/080000
Abstract:
Symmetrically disubstituted aromatic compounds and pharmaceutical compositions containing such compounds that inhibit and/or modulate the activity of poly(ADP-ribose) glycohydrolase, also known as PARG, are described. The invention is also directed to the therapeutic or prophylactic use of such compounds and compositions, and to methods of treating diseases and disorders described herein, by administering effective amounts of such compounds.
Sergei Belyakov - Baltimore MD, US Gregory Hamilton - Catonsville MD, US David Hurst - Santee CA, US Vincent Kalish - Annapolis MD, US Weixing Li - Ellicot City MD, US Eric Wang - San Diego CA, US Douglas Wilkinson - Baltimore MD, US Weizheng Xu - Ellicot City MD, US
International Classification:
C07D277/04 C07D233/60
US Classification:
548200000, 548215000, 548530000, 548334100
Abstract:
Novel inhibitors of dipeptidyl peptidase IV (DPP IV), pharmaceutical compositions comprising therapeutically effective amounts of novel inhibitors of DPP IV, and novel methods of treating medical conditions are provided. The novel inhibitors of DPP IV described herein are useful in the treatment of neurological disorders, diabetes, inflammatory disorders such as arthritis, obesity, osteoporosis, and of such other enumerated conditions as can be treated with inhibitors of DPP IV.
Amine-Based And Amide-Based Inhibitors Of Semicarbazide-Sensitive Amine Oxidase (Ssao)Enzyme Activity And Vap-1 Mediated Adhesion Useful For Treatment Of Diseases
Compositions and methods are disclosed for inhibiting semicarbazide-sensitive amine oxidase (SSAO), also known as vascular adhesion protein-1 (VAP-1). The compounds disclosed are amine-containing and amide-containing compounds. The compounds and compositions are useful for treatment of diseases, including inflammation, inflammatory diseases and autoimmune disorders.
Paul F. Jackson - Bel Air MD Keith M. Maclin - Baltimore MD Eric Wang - Baltimore MD Barbara S. Slusher - Kingsville MD Rena Lapidus - Baltimore MD
Assignee:
Guilford Pharmaceuticals Inc. - Baltimore MD
International Classification:
C07C 5502
US Classification:
562594
Abstract:
The present invention relate to thio-substituted pentanedioic acid derivatives that inhibit N-Acetylated. alpha. -Linked Acidic Dipeptidase (NAALADase) enzyme activity, pharmaceutical compositions comprising the same, and methods of using the same to inhibit NAALADase enzyme activity, to effect neuronal activities, to inhibit angiogenesis, and to treat glutamate abnormalities, compulsive disorders and prostate diseases.
Philadelphia Department of Public Health Tuberculosis Control Program
Aug 2010 to 2000 Graduate Intern/EpidemiologistUnited Biosource Corporation
Jun 2010 to 2000 SAS Clinical ProgrammerDepartment of Behavioral Health
May 2010 to 2000 Gambling Task Force MemberPublic Interest Law Center of Philadelphia
Jan 2010 to 2000 Graduate Intern/EpidemiologistOrange County Chinese American Chamber of Commerce Lake Forest, CA Jan 2009 to Jan 2010 President's AssistantElanbor Corp Tustin, CA Jun 2003 to Jun 2008 Manager's AssistantElanbor Corp Laguna Hills, CA Jun 2004 to Jun 2007 Assistant ManagerElanbor Corp Lake Forest, CA Nov 2006 to Dec 2006 Pharmacy TechnicianImmediately Lake Forest, CA Jun 2000 to Jun 2006 Private TutorKingston Technology Westminster, CA May 1998 to Aug 1998 Entry Level Technician
Education:
St. John's University Jamaica, NY May 2006 Bachelors of Science in BiologyDrexel University Philadelphia, PA Masters of Public Health
Medicine Doctors
Dr. Eric X Wang, Philadelphia PA - DMD (Doctor of Dental Medicine)
Dr. Wang graduated from the Tongji Med Univ, Wuhan City, Hubei, China in 1986. He works in Canton, OH and 1 other location and specializes in Internal Medicine. Dr. Wang is affiliated with Aultman Hospital and Mercy Medical Center.
Kaiser Permanente Medical GroupKaiser Permanente Sacramento Medical Center 2345 Fair Oaks Blvd, Sacramento, CA 95825 916 973-5000 (phone), 916 480-6424 (fax)
Education:
Medical School New York University School of Medicine Graduated: 1999
Chinese Hospital Nursing 845 Jackson St, San Francisco, CA 94133 415 982-2400 (phone), 415 677-2440 (fax)
Education:
Medical School University of California, Los Angeles David Geffen School of Medicine Graduated: 2002
Languages:
English
Description:
Dr. Wang graduated from the University of California, Los Angeles David Geffen School of Medicine in 2002. He works in San Francisco, CA and specializes in Diagnostic Radiology.
Dr. Wang graduated from the Johns Hopkins University School of Medicine in 1999. He works in Monroe, NC and 8 other locations and specializes in Diagnostic Radiology and Vascular & Interventional Rad. Dr. Wang is affiliated with Carolina Health Care System Union, Carolinas Healthcare System Anson, Carolinas HealthCare System University, Carolinas Healthcare System-Lincoln, Carolinas Medical
The work was led by co-first authors Eric Wang, a Yale College undergraduate, Jon Klein, a Yale M.D./Ph.D. student, and Yale Immunobiology graduate students Tianyang Mao and Yile Dai. Funding for the project was provided by the Mathers Family Foundation and the Ludwig Family Foundation.
Date: May 19, 2021
Category: More news
Source: Google
Democratic group attacks Roy Moore without disclosing donors
is not new. In a lot of cases, payments might be made later on if it is customary for those particular vendors to extend credit, said Eric Wang, a Republican campaign finance attorney at Wiley Rein, who previously worked at the Federal Election Commission and is not working on the Alabama race.
Date: Dec 01, 2017
Category: U.S.
Source: Google
Hemp Producer Ecofibre Ditches Australia's Medical Cannabis Rules for the US
The draconian measures being put in place in Australia do not in any way support patients rights to access medicinal cannabis and equally makes it commercially unviable for producers and manufacturers, said Eric Wang, Ecofibres director and chief finance officer.
Date: Dec 21, 2016
Category: Health
Source: Google
Taiwanese Vote in Election That Will Shape Ties With China
You can argue Ma overlooked some of the domestic issues, but its easy to criticize others, said Eric Wang, 27, a graphic designer who voted for Ma today. I dont see any concrete solutions by Tsai, I dont think Tsai can do a better job than Ma given such challenging global conditions.
California, USASr. Consultant at Digital Works Global Solutions,... Past: Vice President, Information Technologies at IndyMac Bank, Sr. Consultant / Project Manager...