Eric A Hryhorenko

US Patent:

20060160161, Jul 20, 2006

Filed:

Oct 26, 2005

Appl. No.:

11/260047

Inventors:

Danka Pavliakova - Montebello NY, US
Eric Hryhorenko - Hilton NY, US
Stephen Hildreth - Clarks Summit PA, US

Assignee:

ELAN PHARMACEUTICALS, INC. - South San Francisco CA

International Classification:

G01N 33/537
G01N 33/53
G01N 33/543

US Classification:

435007920

Abstract:

The invention provides methods for assessing immunoglobulins directed to neurodegenerative disease-associated antigens. Methods of the instant invention involve specific, sensitive and precise identification of Ig classes of antibodies present in a test sample that are capable of binding an immobilized neurodegenerative disease-associated antigen. The enhanced assessment of antibodies directed to specific neurodegenerative disease-associated antigens that is enabled by the invention improves both monitoring of neurodegenerative disease treatment and prediction of neurodegenerative disease progression.

US Patent:

20180117169, May 3, 2018

Filed:

Oct 20, 2017

Appl. No.:

15/789824

Inventors:

- Beerse, BE
Rhys Salter - Doylestown PA, US
Thomas R. DeCory - Pittsford NY, US
Eric Hryhorenko - Hilton NY, US
Bart Remmerie - Gent, BE
Banumathi Sankaran - Lexington MA, US

Assignee:

Janssen Pharmaceutica NV - Beerse

International Classification:

C07D 401/14
C07D 401/12
C07D 215/227
C07D 215/22
A61K 39/385
A61K 31/497
A61K 31/496
A61K 39/00

Abstract:

The invention relates to compounds of Formula I, wherein R, R, and Rare defined in the specification, useful for the synthesis of novel conjugates and immunogens derived from aripiprazole. The invention also relates to conjugates of an aripiprazole hapten and a protein.

US Patent:

20170072061, Mar 16, 2017

Filed:

Nov 3, 2016

Appl. No.:

15/342772

Inventors:

- Beerse, BE
Rhys Salter - Doylestown PA, US
Thomas R. Decory - Pittsford NY, US
Eric Hryhorenko - Hilton NY, US
Bart M. Remmerie - Gent, BE
Banumathi Sankaran - Pittsford NY, US

Assignee:

Janssen Pharmaceutica NV - Beerse

International Classification:

A61K 47/48
A61K 39/385
C07D 215/227
A61K 31/497
C07D 401/12

Abstract:

The invention relates to compounds of Formula I, wherein R, R, and Rare defined in the specification, useful for the synthesis of novel conjugates and immunogens derived from aripiprazole. The invention also relates to conjugates of an aripiprazole hapten and a protein.

US Patent:

20140221616, Aug 7, 2014

Filed:

Aug 20, 2013

Appl. No.:

13/970667

Inventors:

- Raritan NJ, US
- Beerse, BE
Rhys Salter - Doylestown PA, US
Eric Hryhorenko - Hilton NY, US
Thomas R. DeCory - Pittsford NY, US
Bart Remmerie - Gent, BE
Banumathi Sankaran - Pittsford NY, US

Assignee:

Ortho-Clinical Diagnostics, Inc. - Raritan NJ
Janssen Pharmaceutica NV - Beerse

International Classification:

G01N 33/53

US Classification:

530367, 540551, 530380, 530350

Abstract:

The invention relates to compounds of Formula I, wherein R, R, and Rare defined in the specification, useful for the synthesis of novel conjugates and immunogens derived from quetiapine. The invention also relates to conjugates of a quetiapine hapten and a protein.

US Patent:

20140213766, Jul 31, 2014

Filed:

Aug 20, 2013

Appl. No.:

13/970653

Inventors:

- Raritan NJ, US
- Beerse, BE
Rhys SALTER - Doylestown PA, US
Eric HRYHORENKO - Hilton NY, US
Thomas R. DeCORY - Pittsford NY, US
Bart REMMERIE - Gent, BE
Banumathi SANKARAN - Pittsford NY, US

Assignee:

Ortho-Clinical Diagnostics, Inc. - Raritan NJ
JANSSEN PHARMACEUTICA NV - Beerse

International Classification:

C07D 495/04
C07K 14/77
A61K 47/48
C07K 14/47

US Classification:

530367, 540557, 530350, 530380

Abstract:

The invention relates to compounds of Formula I, wherein R, R, and Rare defined in the specification, useful for the synthesis of novel conjugates and immunogens derived from olanzipine. The invention also relates to conjugates of an olanzipine hapten and a protein.

US Patent:

20140213767, Jul 31, 2014

Filed:

Aug 20, 2013

Appl. No.:

13/970660

Inventors:

- Raritan NJ, US
- Beerse, BE
Eric Hryhorenko - Hilton NY, US
Thomas R. DeCory - Pittsford NY, US
Banumathi Sankaran - Pittsford NY, US

Assignee:

Ortho-Clinical Diagnostics, Inc. - Raritan NJ
Janssen Pharmaceutica NV - Beerse

International Classification:

C07D 471/04
C07K 14/77
A61K 47/48
C07K 14/47

US Classification:

530367, 544282, 530350, 530380

Abstract:

The invention relates to compounds of Formula I, wherein L, L, and Lare defined in the specification, useful for the synthesis of novel conjugates and immunogens derived from paliperidone. The invention also relates to conjugates of a paliperidone hapten and a protein.

US Patent:

20140163206, Jun 12, 2014

Filed:

Aug 20, 2013

Appl. No.:

13/970650

Inventors:

- Raritan NJ, US
- Beerse, BE
Thomas R. DeCORY - Pittsford NY, US
Eric HRYHORENKO - Hilton NY, US
Bart REMMERIE - Gent, BE
Banumathi SANKARAN - Pittsford NY, US

Assignee:

Ortho-Clinical Diagnostics, Inc. - Raritan NJ
JANSSEN PHARMACEUTICA NV - Beerse

International Classification:

C07D 401/12
A61K 47/48
C07D 401/14
A61K 31/496

US Classification:

530367, 544363, 530380, 530400

Abstract:

The invention relates to compounds of Formula I, wherein R, R, and Rare defined in the specification, useful for the synthesis of novel conjugates and immunogens derived from aripiprazole. The invention also relates to conjugates of an aripiprazole hapten and a protein.

US Patent:

20140155585, Jun 5, 2014

Filed:

Aug 20, 2013

Appl. No.:

13/970673

Inventors:

- Raritan NJ, US
- Beerse, BE
Eric HRYHORENKO - Hilton NY, US
Thomas R. DeCORY - Pittsford NY, US
Banumathi SANKARAN - Pittsford NY, US

Assignee:

Ortho-Clinical Diagnostics, Inc. - Raritan NJ
Janssen Pharmaceutica NV - Beerse

International Classification:

C07K 16/44
C07D 487/04

US Classification:

530395, 544282, 530400

Abstract:

The invention relates to compounds of Formula I, wherein Rand Rare defined in the specification, useful for the synthesis of novel conjugates and immunogens derived from risperidone and paliperidone. The invention also relates to conjugates of a risperidone or paliperidone hapten and a protein.