Eric D Dowdy

US Patent:

7648998, Jan 19, 2010

Filed:

Dec 21, 2004

Appl. No.:

10/583814

Inventors:

Steven S. Bondy - Danville CA, US
Eric Davis Dowdy - Foster City CA, US
Choung U. Kim - San Carlos CA, US
David A. Oare - Belmont CA, US
Johan Neyts - Kessel-Lo, BE
Vahid Zia - San Carlos CA, US
Gerhard Pürstinger - Igls, AU

Assignee:

K.U. Leuven Research & Development - Leuven
Gilead Sciences, Inc. - Foster City CA

International Classification:

C07D 471/04
A61K 31/437

US Classification:

514303, 546118

Abstract:

The present invention relates to a pharmaceutical composition for the treatment or prevention of viral infections comprising as an active principle at least one imidazo[4,5-c]pyridine prodrug having the general Formula (A) wherein the substituents are described in the specification. The invention also relates to processes for the preparation and screening ofcompounds according to the invention having above mentioned general Formula and their use in the treatment or prophylaxis of viral infections.

US Patent:

7825252, Nov 2, 2010

Filed:

Sep 11, 2007

Appl. No.:

11/853606

Inventors:

Eric Dowdy - Foster City CA, US
Xi Chen - Santa Clara CA, US
Steven Pfeiffer - Pleasanton CA, US

Assignee:

Gilead Sciences, Inc. - Foster City CA

International Classification:

C07D 215/38

US Classification:

546159, 546163

Abstract:

The invention provides synthetic processes and synthetic intermediates that can be used to prepare 4-oxoquinolone compounds having useful integrase inhibiting properties.

US Patent:

8106054, Jan 31, 2012

Filed:

Jul 3, 2008

Appl. No.:

12/217347

Inventors:

Eric D. Dowdy - Foster City CA, US
Kenneth M. Kent - Sunnyvale CA, US
Norma J. Tom - Belmont CA, US
Vahid Zia - San Carlos CA, US

Assignee:

Gilead Sciences, Inc. - Foster City CA
K.U. Leuven Research & Development - Leuven

International Classification:

C07D 403/06
A61K 31/50
A61P 1/16

US Classification:

51425204, 544238

Abstract:

A crystalline compound of formula (1) and its salts and solvates are provided for the treatment or prophylaxis of hepatitis C virus infections.

US Patent:

8153801, Apr 10, 2012

Filed:

Sep 11, 2008

Appl. No.:

12/676553

Inventors:

Eric Dowdy - Foster City CA, US
Steven Pfeiffer - Foster City CA, US

Assignee:

Gilead Sciences, Inc. - Foster City CA

International Classification:

C07D 215/56
C07D 233/60
C07C 43/23
C07C 41/30
C07C 51/15
C07C 51/60
C07C 67/343
C07C 229/34

US Classification:

546156, 5483341, 560 39, 560 53, 562423, 562861, 568628, 568641

Abstract:

The invention provides synthetic processes and synthetic intermediates that can be used to prepare 4-oxoquinolone compounds having useful integrase inhibiting properties.

US Patent:

8173623, May 8, 2012

Filed:

Mar 29, 2007

Appl. No.:

11/729522

Inventors:

Kenneth R. Crawford - Burke VA, US
Eric Dowdy - Foster City CA, US
Arnold Gutierrez - San Jose CA, US
Richard P. Polniaszek - Redwood City CA, US
Richard Hung Chiu Yu - San Francisco CA, US

Assignee:

Gilead Sciences, Inc. - Foster City CA

International Classification:

A61K 31/665

US Classification:

514100

Abstract:

A process for the synthesis of bisfuran intermediates useful for preparing antiviral HIV protease inhibitor compounds is hereby disclosed.

US Patent:

8324244, Dec 4, 2012

Filed:

Sep 28, 2010

Appl. No.:

12/892682

Inventors:

Eric Dowdy - Foster City CA, US
Xi Chen - Santa Clara CA, US
Steven Pfeiffer - Temecula CA, US

Assignee:

Gilead Sciences, Inc. - Foster City CA

International Classification:

A61K 31/47
A61K 31/4174
A61K 31/216
C07D 215/20
C07D 233/20
C07C 69/773

US Classification:

514312, 546159, 546163, 5483341, 560 57, 514390, 514532

Abstract:

The invention provides synthetic processes and synthetic intermediates that can be used to prepare 4-oxoquinolone compounds having useful integrase inhibiting properties.

US Patent:

8329727, Dec 11, 2012

Filed:

Oct 13, 2009

Appl. No.:

12/577865

Inventors:

Steven S. Bondy - Danville CA, US
Eric Davis Dowdy - Foster City CA, US
Choung U. Kim - San Carlos CA, US
David A. Oare - Belmont CA, US
Johan Neyts - Kessel-Lo, BE
Vahid Zia - San Carlos CA, US
Gerhard Pürstinger - Igls, AT

Assignee:

Gilead Sciences, Inc. - Foster City CA
K.U. Leuven Research & Development - Leuven

International Classification:

A61K 31/437
A61K 38/21
A61K 31/708
C07D 471/04
A61P 3/12

US Classification:

514303, 514 43, 546118, 424 857

Abstract:

The present invention relates to pharmaceutical compositions for the treatment or prevention of viral infections comprising as an active principle at least one imidazo[4,5-c]pyridine prodrug having the general Formula (A) wherein the substituents are described in the specification. The invention also relates to processes for the preparation and screening of compounds according to the invention having above mentioned general Formula and their use in the treatment or prophylaxis of viral infections.

US Patent:

8431745, Apr 30, 2013

Filed:

Feb 21, 2012

Appl. No.:

13/401659

Inventors:

Kenneth R. Crawford - Westwood MA, US
Eric D. Dowdy - Foster City CA, US
Arnold Gutierrez - San Jose CA, US
Richard P. Polniaszek - Half Moon Bay CA, US
Richard Hung Chiu Yu - San Francisco CA, US

Assignee:

Gilead Sciences, Inc. - Foster City CA

International Classification:

C07C 381/00

US Classification:

564 89

Abstract:

A process for the synthesis of bisfuran intermediates useful for preparing antiviral HIV protease inhibitor compounds is hereby disclosed.