Emery H Bresnick

US Patent:

20060281670, Dec 14, 2006

Filed:

Jun 9, 2006

Appl. No.:

11/450502

Inventors:

Emery Bresnick - Madison WI, US
Soumen Paul - Madison WI, US

International Classification:

A61K 38/17
A61K 38/22
A61K 38/12

US Classification:

514009000, 514012000, 514015000

Abstract:

Methods and compositions for modulating angiogenesis are disclosed. Such modulation is made possible by the use of NK-B, NK-B analogs, NK receptor agonists and NK receptor antagonists to promote or inhibit angiogenesis. The method for modulating the angiogenic activity of cells comprises contacting cells capable of angiogenesis with an effective amount of NK-B, an NK-B analog, an NK receptor agonist or an NK receptor antagonist wherein the angiogenic activity of the cells is increased or decreased. The angiogenesis modulating compounds can be administered to alleviate and or prevent angiogenesis related diseases in patients, such as, for example, cancer, rheumatoid arthritis, macular degeneration, atherosclerosis, coronary artery disease, peripheral vascular disease, varicose veins and preeclampsia.

US Patent:

20030148954, Aug 7, 2003

Filed:

Nov 4, 2002

Appl. No.:

10/287196

Inventors:

Emery Bresnick - Middleton WI, US
Jason Norton - Madison WI, US
Jianlin Chu - Madison WI, US

Assignee:

Wisconsin Alumni Research Foundation

International Classification:

A61K038/17
C12Q001/68
G01N033/53
G01N033/567

US Classification:

514/012000, 435/006000, 435/007200

Abstract:

Agents for modulating AP-1 mediated gene expression are provided. The modulating agents comprise an internalization moiety and: (1) a peptide sequence isolated from the intracellular domain of Notch-1 (NIC-1); or (2) a peptide analogue or peptidomimetic of the NIC-1 peptide sequence. Methods of using the modulating agents for modulating AP-1 mediated gene expression in a variety of contexts (e.g., for modulating inflammatory and immunosuppressive activities) are provided.

Address:

6715 Shamrock Gln Cir, Middleton, WI 53562

Phone:

608 826-0999

VIN:

JN1CV6AR7AM251478

Make:

INFINITI

Model:

G37 SEDAN

Year:

2010