Elvin A Kabat

US Patent:

6287568, Sep 11, 2001

Filed:

Sep 9, 1998

Appl. No.:

9/149997

Inventors:

Denong Wang - New York NY
Bernard F. Erlanger - Whitestone NY
Elvin A. Kabat - Falmouth MA

Assignee:

The Trustees of Columbia University in the City of New York - New York NY

International Classification:

A01N 6500

US Classification:

42419711

Abstract:

This invention includes the conception of T-independent conjugate-vaccines and its application in the induction of antigen specific IgA response. We demonstrated that 1). alpha. (1,6)dextran can elicit a markedly enhanced IgA response in T-cell free mice (20-50 fold higher than in normal mice); 2)co-injection of the molecule with other antigens can enhance the IgA response to the co-antigen; and 3)a dextran-Gag conjugate can elicit the Gag-specific IgA. Thus, the invention identified. alpha. (1,6)dextran as a carrier molecule for producing the T-independent conjugates and as an adjuvant for the enhancement of IgA production. The T-independent property of these conjugates makes it especially useful in vaccinations against HIV and other infectious and non-infectious diseases associated with T-cell deficiency.

Author:

Elvin A. Kabat

ISBN #:

0030895421

Author:

Elvin A. Kabat

ISBN #:

0387051538