Timothy D. Bartley - Thousand Oaks CA William J. Boyle - Moorpark CA Gary M. Fox - Newbury Park CA Andrew A. Welcher - Glendale CA Ella Magal - Thousand Oaks CA Richard A. Lindberg - Thousand Oaks CA Vann P. Parker - Newbury Park CA
Assignee:
Amgen Inc. - Thousand Oaks CA
International Classification:
C12Q 148
US Classification:
435 15
Abstract:
Ligands which bind to the eck receptor are disclosed. More particularly, polypeptides which bind specifically to the eck receptor (eck receptor binding proteins or EBPs) and DNA sequences encoding said polypeptides are disclosed. Methods of treatment using eck receptor ligands and soluble eck receptor and disclosed, as are pharmaceutical compositions containing same. A rapid and sensitive method for the detection of receptor binding activity in crude samples is provided.
Method For Preventing And Treating Hearing Loss Using Sensorineurotrophic Compounds
The present invention relates generally to methods for preventing and/or treating injury or degeneration of cochlear hair cells and spiral ganglion neurons by administering sensorineurotrophic compounds described below. The invention relates more specifically to methods for treating sensorineural hearing loss as well as vestibular disorders and tinnitus.
Method For Preventing And Treating Hearing Loss Using A Neuturin Protein Product
Ella Magal - Thousand Oaks CA John M. Delaney - Newbury Park CA
Assignee:
Amgen Inc. - Thousand Oaks CA
International Classification:
A61K 3800 C07K 500 C07K 700
US Classification:
514 12
Abstract:
The present invention relates generally to methods for preventing and/or treating injury or degeneration of cochlear hair cells and spiral ganglion neurons by administering a neurturin neurotrophic factor protein product. The invention relates more specifically to methods for treating sensorineural hearing loss.
Timothy D. Bartley - Thousand Oaks CA William J. Boyle - Moorpark CA Gary M. Fox - Newbury Park CA Andrew A. Welcher - Glendale CA Ella Magal - Thousand Oaks CA Richard A. Lindberg - Thousand Oaks CA Vann P. Parker - Newbury Park CA
Assignee:
Amgen Inc. - Thousand Oaks CA
International Classification:
C12N 500 C12N 508 C12N 506 A61K 3800
US Classification:
435325
Abstract:
Ligands which bind to the eck receptor are disclosed. More particularly, polypeptides which bind specifically to the eck receptor (eck receptor binding proteins or EBPs) and DNA sequences encoding said polypeptides are disclosed. Methods of treatment using eck receptor ligands and soluble eck receptor and disclosed, as are pharmaceutical compositions containing same. A rapid and sensitive method for the detection of receptor binding activity in crude samples is provided.
Method For Treating Sensorineural Hearing Loss Using Glial Cell Line-Derived Neurotrophic Factor (Gdnf) Protein Product
The present invention relates generally to methods for preventing and/or treating injury or degeneration of cochlear hair cells and spiral ganglion neurons by administering glial cell line-derived neurotrophic factor (GDNF). The invention relates more specifically to methods for treating sensorineural hearing loss.
Method For Preventing And Treating Sensorineural Hearing Loss And Vestibular Disorders Using Glial Cell Line-Derived Neurotrophic Factor(Gdnf) Protein Product
The present invention relates generally to methods for preventing and/or treating injury or degeneration of cochlear (and vestibular) hair cells and spiral ganglion neurons (as well as vestibular neurons--Carpa's neurons) by administering glial cell line-derived neurotrophic factor (GDNF). The invention relates more specifically to methods for treating sensorineural hearing loss and vestibular disorders.
Timothy D. Bartley - Thousand Oaks CA William J. Boyle - Moorpark CA Gary M. Fox - Newbury Park CA Andrew A. Welcher - Glendale CA Ella Magal - Thousand Oaks CA Richard A. Lindberg - Thousand Oaks CA Vann P. Parker - Newbury Park CA
Assignee:
Amgen Inc. - Thousand Oaks CA
International Classification:
A61K 3845 A61K 3800 C12N 912
US Classification:
424 945
Abstract:
Ligands which bind to the eck receptor are disclosed. More particularly, polypeptides which bind specifically to the eck receptor (eck receptor binding proteins or EBPs) and DNA sequences encoding said polypeptides are disclosed. Methods of treatment using eck receptor ligands and soluble eck receptor and disclosed, as are pharmaceutical compositions containing same. A rapid and sensitive method for the detection of receptor binding activity in crude samples is provided.
Method For Preventing And Treating Hearing Loss Using A Neurturin Protein Product
Ella Magal - Thousand Oaks CA John M. Delaney - Newbury Park CA
Assignee:
Amgen Inc. - Thousand Oaks CA
International Classification:
A61K 3800 C07K 100 C07K 200 C07K 400 C07K 500
US Classification:
514 12
Abstract:
The present invention relates generally to methods for preventing and/or treating injury or degeneration of cochlear hair cells and spiral ganglion neurons by administering a neurturin neurotrophic factor protein product. The invention relates more specifically to methods for treating sensorineural hearing loss.