- Cambridge MA, US Cassandra CELATKA - Hull MA, US Seng CHENG - Natick MA, US Mary A. CROMWELL - Groton MA, US Andrew GOOD - Wallingford CT, US Bradford HIRTH - Framingham MA, US Katherine JANCSICS - Wilmington MA, US John P. LEONARD - Manchester NH, US Lingyun LI - Waltham MA, US James LILLIE - Wellesley MA, US Hanlan LIU - Lexington MA, US Elina MAKINO - Winchester MA, US John MARSHALL - Hopedale MA, US Paul MASON - Natick MA, US Markus METZ - Waltham MA, US Fazeela MORSHED - Waltham MA, US Thomas O'SHEA - Wellesley MA, US Ronald SCHEULE - Hopkinton MA, US Renato SKERLJ - West Newton MA, US Bing WANG - Newton MA, US Yibin XIANG - Dracut MA, US Zhong ZHAO - Wayland MA, US
The invention relates to inhibitors of glucosylceramide synthase (GCS) useful for the treatment of metabolic diseases, such as lysosomal storage diseases, either alone or in combination with enzyme replacement therapy, and for the treatment of cancer.
- Cambridge MA, US Cassandra CELATKA - Hull MA, US Seng CHENG - Natick MA, US Mary A. CROMWELL - Groton MA, US Andrew GOOD - Wallingford CT, US Bradford HIRTH - Framingham MA, US Katherine JANCSICS - Wilmington MA, US John P. LEONARD - Manchester NH, US Lingyun LI - Waltham MA, US James LILLIE - Wellesley MA, US Hanlan LIU - Lexington MA, US Elina MAKINO - Winchester MA, US John MARSHALL - Hopedale MA, US Paul MASON - Natick MA, US Markus METZ - Waltham MA, US Fazeela MORSHED - Waltham MA, US Thomas O'SHEA - Wellesley MA, US Ronald SCHEULE - Hopkinton MA, US Renato SKERLJ - West Newton MA, US Bing WANG - Newton MA, US Yibin XIANG - Dracut MA, US Zhong ZHAO - Wayland MA, US
The invention relates to inhibitors of glucosylceramide synthase (GCS) useful for the treatment of metabolic diseases, such as lysosomal storage diseases, either alone or in combination with enzyme replacement therapy, and for the treatment of cancer.
- Cambrdige MA, US Cassandra CELATKA - Hull MA, US Seng H. CHENG - Natick MA, US Bradford Hirth - Littleton MA, US Andrew GOOD - Wallingford CT, US Katherine JANCSICS - Wilmington MA, US John MARSHALL - Charlestown MA, US Markus Metz - Encinitas CA, US Ronald K. SCHEULE - Hopkinton MA, US Renato SKERLJ - W. Newton MA, US Yibin XIANG - Dracut MA, US Zhong ZHAO - Wayland MA, US John LEONARD - Manchester NH, US Thomas NATOLI - Revere MA, US Elina MAKINO - Winchester MA, US Herve HUSSON - Boston MA, US Oxana BESKROVNAYA - Southborough MA, US
The invention relates to inhibitors of glucosylceramide synthase (GCS) useful for the treatment of metabolic diseases, such as lysosomal storage diseases, either alone or in combination with enzyme replacement therapy, cystic disease and for the treatment of cancer.
- Cambridge MA, US Cassandra CELATKA - Hull MA, US Seng CHENG - Natick MA, US Mary A. CROMWELL - Groton MA, US Andrew GOOD - Wallingford CT, US Bradford HIRTH - Framingham MA, US Katherine JANCSICS - Wilmington MA, US John P. LEONARD - Manchester NH, US Lingyun LI - Waltham MA, US James LILLIE - Wellesley MA, US Hanlan LIU - Lexington MA, US Elina MAKINO - Winchester MA, US John MARSHALL - Hopedale MA, US Paul MASON - Natick MA, US Markus METZ - Waltham MA, US Fazeela MORSHED - Waltham MA, US Thomas O'SHEA - Wellesley MA, US Ronald SCHEULE - Hopkinton MA, US Renato SKERLJ - West Newton MA, US Bing WANG - Newton MA, US Yibin XIANG - Dracut MA, US Zhong ZHAO - Wayland MA, US
The invention relates to inhibitors of glucosylceramide synthase (GCS) useful for the treatment metabolic diseases, such as lysosomal storage diseases, either alone or in combination with enzyme replacement therapy, and for the treatment of cancer.
- Cambridge MA, US Cassandra Celatka - Chesterfield MA, US Seng H. Cheng - Wellesley MA, US Bradford Hirth - Littleton MA, US Andrew Good - Wallingford CT, US Katherine Jancsics - Wilmington MA, US John Marshall - Hopedale MA, US Markus Metz - Waltham MA, US Ronald K. Scheule - Hopkinton MA, US Renato Skerlj - Newton MA, US Yibin Xiang - Dracut MA, US Zhong Zhao - Wayland MA, US John Leonard - Bridgewater NJ, US Thomas Natoli - Southborough MA, US Elina Makino - Winchester MA, US Herve Husson - Boston MA, US Oxana Beskrovnaya - Southborough MA, US
The invention relates to inhibitors of glucosylceramide synthase (GCS) useful for the treatment of metabolic diseases, such as lysosomal storage diseases, either alone or in combination with enzyme replacement therapy, cystic disease and for the treatment of cancer.
Sigilon Therapeutics, Inc.
Senior Director, Rare Disease
Sanofi Jun 2007 - Aug 2018
Scientific Director
Sanofi Genzyme Jun 2007 - Aug 2018
Scientific Director
Sanofi Genzyme Jun 2007 - Mar 2014
Associate Director
Emd Millipore Jan 2006 - May 2007
Senior Scientist
Education:
Weizmann Institute of Science 1990 - 1995
Doctorates, Doctor of Philosophy, Biochemistry, Philosophy
Moscow State University
Skills:
Drug Discovery Biochemistry Assay Development Biotechnology High Throughput Screening Cell Drug Development Life Sciences Oncology Cell Culture Neuroscience In Vitro Pharmaceutical Industry Molecular Biology Immunology Molecular and Cellular Biology Cell Biology Lifesciences Biopharmaceuticals Technology Transfer Genomics Elisa Dna Protein Chemistry Purification Pcr Genetics Rare Diseases Opthalmology Clinical Biomarkers Rare Disease
Mar 2009 to 2000 Associate Director, In Vitro Biology Group, Drug and Biomaterial R&DMillipore Corporation
Jan 2006 to May 2007 Senior Research Scientist I, Technology Development GroupElina Makino Cambridge, MA May 2005 to Nov 2005 Senior Scientist I, Assay Development, Cell BiologyScientist II, Assay Development, cell biology May 2000 to May 2005Department of Ophthalmology, Harvard Medical School Boston, MA Dec 1995 to Apr 2000 Postdoctoral FellowElina Makino
1990 to 1995 Predoctoral FellowA.N. Belozersky, Laboratory of Molecular Biology and Bioorganic Chemistry
1988 to 1990 Junior Research Scientist
Education:
Harvard Medical School 1995 to 2000 Ph.D. in BiochemistryWeizmann Institute of Science M.S. in Biochemistry
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