Edwin Mercer Stone

Author:

Edwin Martin Stone

ISBN #:

0405040903

Author:

Edwin M. Stone

ISBN #:

0195043375

Author:

Edwin M. Stone

ISBN #:

0832823473

US Patent:

6403307, Jun 11, 2002

Filed:

Apr 7, 1998

Appl. No.:

09/056285

Inventors:

Edwin M. Stone - Iowa City IA
Val C. Sheffield - Coralville IA
Wallace L. M. Alward - Iowa City IA
John Fingert - Iowa City IA

Assignee:

University of Iowa Research Foundation - Iowa City IA

International Classification:

C12Q 168

US Classification:

435 6, 435 912, 536 231, 536 243

Abstract:

Methods and compositions for preventing and treating glaucoma; and glaucoma diagnostics are disclosed.

US Patent:

6417342, Jul 9, 2002

Filed:

Feb 12, 1999

Appl. No.:

09/248757

Inventors:

Edwin M. Stone - Iowa City IA
Val C. Sheffield - Coralville IA

Assignee:

University of Iowa Research Foundation - Iowa City IA

International Classification:

C07H 2104

US Classification:

536 235, 4352523, 435325, 4353201

Abstract:

Therapeutics and diagnostics based on the identification of genetic mutations, which cause Macular Degeneration (MD) is disclosed.

US Patent:

6593104, Jul 15, 2003

Filed:

May 28, 1999

Appl. No.:

09/322357

Inventors:

Edwin M. Stone - Iowa City IA
Val C. Sheffield - Coralville IA

Assignee:

University of Iowa Research Foundation - Iowa City IA

International Classification:

C12N 1500

US Classification:

435 691, 4353201, 435325, 435455, 536 231, 536 235

Abstract:

Therapeutics and diagnostics based on the identification of genetic mutations, which cause Macular Degeneration (MD) are disclosed.

US Patent:

6833239, Dec 21, 2004

Filed:

Jul 10, 2000

Appl. No.:

09/612809

Inventors:

Val C. Sheffield - Coralville IA
Wallace L. M. Alward - Iowa City IA
Edwin M. Stone - Iowa City IA
Darryl Nishimura - Coralville IA
Shiva Patil - Iowa City IA

Assignee:

The University of Iowa Research Foundation - Iowa City IA

International Classification:

C12Q 168

US Classification:

435 6, 435 4, 435 71, 4353201, 4352351, 435 691, 536 231, 536 241, 530350

Abstract:

Methods and compositions for treating a congenital heart disease and methods and compositions for prognosing or diagnosing a congenital heart disease in a subject are disclosed.

US Patent:

6956103, Oct 18, 2005

Filed:

Sep 12, 2001

Appl. No.:

09/952464

Inventors:

Edwin M. Stone - Iowa City IA, US
Val C. Sheffield - Iowa City IA, US
Wallace L. M. Alward - Iowa City IA, US
John Fingert - Iowa City IA, US

Assignee:

The University of Iowa Research Foundation - Iowa City IA

International Classification:

C07K001/00
C07K014/00
C07H021/04

US Classification:

530350, 536 231, 536 243

Abstract:

Methods and compositions for preventing and treating glaucoma; and glaucoma diagnostics are disclosed.

US Patent:

6962788, Nov 8, 2005

Filed:

May 28, 2003

Appl. No.:

10/447322

Inventors:

Val C. Sheffield - Iowa City IA, US
Kirk Mykytyn - Iowa City IA, US
Darryl Y. Nishimura - Coralville IA, US
Edwin M. Stone - Iowa City IA, US
Charles C. Searby - Iowa City IA, US

Assignee:

University of Iowa Research Foundation - Iowa City IA

International Classification:

G01N033/68
C12P021/02
C12N015/63
C07H021/04

US Classification:

435 71, 435 691, 4353201, 530350, 536 235

Abstract:

The present invention relates to the identification of a gene, mutated at the most common locus now designated BBS1, that is involved in the genetic disease Bardet Biedl Syndrome (BBS), which is characterized by such diverse symptoms as obesity, diabetes, hypogonadism, mental retardation, renal cancer and other renal abnormalities, retinopathy and polydactyly or limb deformities. The human BBS1 protein disclosed herein is composed of 17 exons and spans approximately 23 kb. Methods of use for the gene, for example in diagnosis and therapy of BBS and in drug screening, also are described.

US Patent:

7008782, Mar 7, 2006

Filed:

Dec 18, 2001

Appl. No.:

10/025187

Inventors:

Val Sheffield - Iowa City IA, US
Darryl Nishimura - Coralville IA, US
Edwin Stone - Iowa City IA, US

Assignee:

The University Iowa Research Foundation - Iowa City IA

International Classification:

C12N 9/00

US Classification:

435183, 435 6, 4353201, 435325

Abstract:

The present invention relates to the identification of a gene, now designated negevin (ngvn), that is involved in the genetic disease Bardet Biedl Syndrome (BBS), which is characterized by such diverse symptoms as obesity, diabetes, hypertension, mental retardation, renal cancer and other abnormalities, retinopathy and hypogonadism. The human NGVN protein disclosed herein is 731 amino acids in length and is coded for by a gene spanning 17 exons. Homologs have been identified in mouse, rat, zebrafish. Methods of use for the gene, for example in diagnosis and therapy of BBS and in drug screening, also are described.

US Patent:

7033755, Apr 25, 2006

Filed:

Feb 28, 2001

Appl. No.:

09/796008

Inventors:

Abbot F. Clark - Arlington TX, US
John Fingert - Iowa City IA, US
Loretta McNatt - Hurst TX, US
Edwin M. Stone - Iowa City IA, US
Wan-Heng Wang - Grapevine TX, US

Assignee:

Alcon, Inc. - Hunenberg
University of Iowa Research Foundation - Iowa City IA

International Classification:

C07H 21/04
C12Q 1/68

US Classification:

435 6, 435 911, 536 231

Abstract:

Methods and compositions for diagnosing and treating glaucoma are disclosed.