Daniel T. Kamei - Monterey Park CA, US Bert J. Lao - Los Angeles CA, US Wen-Lin P. Tsai - Oceanside CA, US Foad Mashayekhi - Los Angeles CA, US Edward A. Pham - Midway City CA, US Anne B. Mason - Charlotte VT, US
Assignee:
The Regents of the University of California Office of Technology Transfer - Oakland CA Office of Technology Transfer, University of Vermont - Burlington VT
International Classification:
A61K 38/40 A61P 35/00 C07K 14/79
US Classification:
514 153, 530395
Abstract:
The invention provides modified Transferrin (Tf) molecules and conjugates of the Tf molecules with a therapeutic agent. The invention also provides methods of treating cancer wherein the therapeutic agents are chemotherapeutic agents. The modified Tf molecules improve the delivery of the conjugated agent to a target tissue. In some embodiments, the modified Tf molecule has a mutation which decreases the release of bound iron from a Tf complex. The complex can also contain, for instance, a carbonate, oxalate, or other anion to stabilize the Tf iron complex.
Daniel T. Kamei - Monterey Park CA, US Bert J. Lao - Los Angeles CA, US Wen-Lin P. Tsai - Carlsbad CA, US Foad Mashayekhi - Los Angeles CA, US Edward A. Pham - Midway City CA, US Anne B. Mason - Charlotte VT, US
Assignee:
The Regents of the University of California - Oakland CA
International Classification:
A61K 39/05 C07K 14/79 C12N 9/96
US Classification:
42419711, 530394, 435188
Abstract:
The present invention provides transferrin (Tf) conjugates of anti-cancer agents with increased cellular association and increased cellular internalization. The present invention also provides methods of treating cancer comprising administration of a Tf conjugate with increased cellular association to a subject with cancer. The present invention additionally provides methods of making, as well as screening for, Tf conjugates with increased cellular association or cellular internalization. The present invention also provides Tf conjugates with increased cellular association and internalization for delivering nucleic acids to cancer cells.
Erin Strickler, Ellie Nitchals, Amy Beyer, Brittany Starkey, Austin Wade, B Fra, Gordon Hilberg, Michael Adams, Mary Flynn, Jamie Erway, Andrea Terherst