Clifford M. Bryant - Millbrae CA James T. Palmer - Corte Madera CA Robert M. Rydzewski - Newark CA Eduardo L. Setti - San Mateo CA Shankar Venkatraman - Foster City CA Dan-Xiong Wang - Foster City CA
The present invention relates to novel N-cyanomethyl amides which are cysteine protease inhibitors, the pharmaceutically acceptable salts and N-oxides thereof, their uses as therapeutic agents and the methods of their making.
Renata Marcella Oballa - Kirkland, CA Petpiboon Prasit - Pierrefonds, CA Joel Stephane Robichaud - Dollard des Ormeaux, CA Elise Isabel - Pointe-Claire, CA Eduardo Setti - San Mateo CA Dan-Xiong Wang - Foster City CA Rohan V. Mendonca - South San Francisco CA Shankar Venkatraman - Pleasanton CA
The present invention relates to novel cysteine protease inhibitors of Formula I: the pharmaceutically acceptable salts and N-oxide derivatives thereof, their use as therapeutic agents and methods of making them.
Clifford M. Bryant - Millbrae CA James T. Palmer - Corte Madera CA Robert M. Rydzewski - Newark CA Eduardo L. Setti - San Mateo CA Shankar Venkatraman - Foster City CA Dan-Xiong Wang - Foster City CA
Assignee:
Axys Pharmaceuticals, Inc. - South San Francisco CA
The present invention relates to novel N-cyanomethyl amides which are cysteine protease inhibitors, the pharmaceutically acceptable salts and N-oxides thereof, their uses as therapeutic agents and the methods of their making.
Christopher Ian Bayly - Beaconsfield, CA Joel Stephane Robichaud - Dollard des Ormeaux, CA W. Cameron Black - Baie d'Urfe, CA Eduardo L. Setti - San Mateo CA, US Robert M. Rydzewski - Newark CA, US James T. Palmer - Corte Madera CA, US
Assignee:
Merck & Co., Inc. - Rahway NJ Axys Pharmaceuticals, Inc. - South San Francisco CA
This invention relates to a novel class of compounds which are cysteine protease inhibitors, including but not limited to, inhibitors of cathepsins K, L, S and B. These compounds are useful for treating diseases in which inhibition of bone resorption is indicated, such as osteoporosis.
The present invention is directed to certain hydroxamate derivatives that are inhibitors of histone deacetylase and are therefore useful in the treatment of diseases associated with histone deacetylase activity. Pharmaceutical compositions and processes for preparing these compounds are also disclosed.
Cyanoalkylamino Derivatives As Protease Inhibitors
The present invention is directed to novel cyanoalkylamino derivatives that are inhibitors of cysteine protease such as cathepsins K, S, B and L, in particular cathepsin K Pharmaceutical composition comprising these compounds, method of treating diseases mediated by unregulated cysteine protease activity, in particular cathepsin K utilizing these compounds and methods of preparing these compounds are also disclosed.
Haloalkyl Containing Compounds As Cysteine Protease Inhibitors
The present invention is directed to compounds that are inhibitors of cysteine proteases, in particular, cathepsins B, K, L, F, and S and are therefore useful in treating diseases mediated by these proteases. The present invention is directed to pharmaceutical compositions comprising these compounds and processes for preparing them.
Jak Kinase Modulating Compounds And Methods Of Use Thereof
Sunny Abraham - San Diego CA, US Qi Chao - San Diego CA, US Michael J. Hadd - San Diego CA, US Mark W. Holladay - San Diego CA, US Gang Liu - San Diego CA, US Eduardo Setti - San Mateo CA, US
Assignee:
Ambit Biosciences Corp. - San Diego CA
International Classification:
A61K 31/517
US Classification:
51426623, 544284
Abstract:
Provided herein are quinazoline compounds of formula (I):.