44 Binney St, Boston, MA 02115 617 632-3347 (Phone)
Certifications:
Anatomic Pathology, 1963 Clinical Pathology, 1965
Awards:
Healthgrades Honor Roll
Languages:
English
Hospitals:
44 Binney St, Boston, MA 02115
Dana - Farber Cancer Institute 450 Brookline Avenue, Boston, MA 02115
Education:
Medical School National Center of Colombia / Faculty of Medicine Medical School Hotel Dieu Medical School Childrens Hospital Medical School U Kans Med Ctr Medical School U Minn Hosps
Edmond Yunis, Boston MA
Work:
Dana-Farber Cancer Institute
44 Binney St, Boston, MA 02115
Us Patents
Variants Of Il-1 Beta Gene And Cd46 Gene For Diagnosing Unexplained Recurrent Pregnancy Loss
Joseph Hill - Brookline MA, US Zhigang Wang - West Roxbury MA, US Deborah Anderson - Brookline MA, US Edmond Yunis - Concord MA, US
Assignee:
The Brigham and Women's Hospital, Inc. - Boston MA
International Classification:
C12Q001/68 G01N033/53
US Classification:
435/006000, 436/510000
Abstract:
The discovery of an association between two variants of the human interleukin-1 gene (IL1B) beta promoter region and a variant of the CD46 gene intron 1 and T-helper type 1 immunity in unexplained recurrent pregnancy loss (URPL) is disclosed. These two IL1B variants are characterized by a base C at position-511 (IL1B-511C) and a base T at position-31 (IL1B-31T) from the transcriptional start site of the IL1B gene. The CD46 gene intron 1 variant is characterized by a change in the HindIII site in this intron. These IL1B promoter variants and CD46 gene intron 1 variants, and reagents for detecting said variants, are useful as diagnostic markers for the diagnosis and management of recurrent pregnancy loss. Accordingly, the invention provides methods and compositions which identify these variants for determining a subject's propensity for having reproductive failure and, particularly, reproductive failure attributed to Th1 cytokines.
Jeffrey A. Lieberman - New York NY Edmond J. Yunis - Concord MA
Assignee:
Long Island Jewish Medical Center - New Hyde Park NY Dana-Farber Cancer Institute - Boston MA
International Classification:
G01N 3353
US Classification:
435 724
Abstract:
Certain patients undergoing clozapine drug therapy may be vulnerable to agranulocytosis. It has been found that agranulocytosis vulnerability is correlated with the presence of HLA antigens B38, DR4 and DQw3. Accordingly, a method is provided for detecting such patients, and an HLA kit is provided.
Isbn (Books And Publications)
Tissue Typing And Organ Transplantation: Proceedings