Eckard A Wimmer
age ~88
from Portland, OR
- Also known as:
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- Eckard Astrid Wimmer
- Eckard Ano Wimmer
- Eckard Wimmer Rt
- Wimmer Eckard
Eckard Wimmer Phones & Addresses
- Portland, OR
- Stony Brook, NY
- 17 Childs Ln, East Setauket, NY 11733 • 631 751-2189
- Setauket, NY
- 17 Childs Ln, Setauket, NY 11733
Work
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Company:Stony brook university
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Position:Professor
Us Patents
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Recombinant Poliovirus For The Treatment Of Cancer
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US Patent:6464972, Oct 15, 2002
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Filed:May 8, 2000
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Appl. No.:09/566581
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Inventors:Matthias Gromeier - Stony Brook NY
Eckard Wimmer - East Setauket NY -
Assignee:The Research Foundation of State University of New York - Albany NY
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International Classification:A01N 6300
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US Classification:424 932, 435236
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Abstract:The present invention is directed to non-pathogenic, oncolytic, recombinant polioviruses for the treatment of various forms of malignant tumors. The recombinant polioviruses of the invention are those in which the internal ribosomal entry site (IRES) of the wild type poliovirus was exchanged with the IRES of other picornaviruses, and optionally P1, P3 or the 3âNTR thereof was exchanged with that of poliovirus Sabin type. More particularly, the present invention is directed to the administration of the non-pathogenic, oncolytic, recombinant poliovirus to the tumor directly, intrathecally or intravenously to cause tumor necrosis. The method of the present invention is particularly useful for the treatment of malignant tumors in various organs, such as: breast, colon, bronchial passage, epithelial lining of the gastrointestinal, upper respiratory and genito-urinary tracts, liver, prostate and the brain. Astounding remissions in experimental animals have been demonstrated for the treatment of malignant glioblastoma multiforme, an almost universally fatal neoplasm of the central nervous system.
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Method Of Detecting The Presence Of Cd155 For Diagnosis Of Cancer And To Determine Treatment
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US Patent:6518033, Feb 11, 2003
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Filed:Sep 6, 2000
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Appl. No.:09/655744
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Inventors:Matthias Gromeier - Durham NC
Eckard Wimmer - East Setauket NY -
Assignee:The Research Foundation of State University of New York - Albany NY
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International Classification:G01N 33574
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US Classification:435 723, 435 792, 435 795, 435 4052, 436518, 436527
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Abstract:The present invention relates to a method of diagnosing, classifying and grading of tumor growths and to determine whether the use of chimeric polioviruses is a proper course for the treatment of the tumors. More particularly, the method is directed to the use of antibodies to a poliovirus receptor (PVR), CD155, to detect the presence of CD155 on tumor cells in various organs, such as: breast, colon, bronchial passage, epithelial lining of the gastrointestinal, upper respiratory and genito-urinary tracts, liver, prostate and the brain.
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Efficient Hepatitis C Virus Replicon And Its Use In Identifying Antiviral Compounds
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US Patent:6689559, Feb 10, 2004
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Filed:Nov 29, 2001
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Appl. No.:09/998900
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Inventors:Eckard Wimmer - East Setauket NY
Chengyu Liang - Stony Brook NY
Sung Key Jang - Kyungbuk, KR
Bumsuk Hahm - San Diego CA -
Assignee:The Research Foundation of the State University of New York - Albany NY
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International Classification:C12Q 170
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US Classification:435 5, 435 911, 435 693, 435455, 435475, 435370, 536 2372
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Abstract:The present invention provides a Hepatitis C Virus (HCV) replicon that efficiently replicates in an eukaryotic cell. The HCV replicon includes a nucleic acid sequence encoding a subgenomic fragments of HCV of any genotype that confer on the RNA the ability to replicate, and a nucleic acid sequence encoding an acetyl transferase selectable marker, such as puromycin. Also provided is an HCV type 1a replicon that efficiently replicates in an eukaryotic cell and includes a nucleic acid sequence encoding subgenomic fragments of type 1a HCV that confer on the RNA the ability to replicate, and a nucleic acid sequence encoding a acetyl transferase selectable marker. Further provided are eukaryotic cell lines that include an HCV replicon or an HCV type 1a replicon which efficiently replicate in the eukaryotic cell. The present invention also provides screening methods for identifying candidate compounds that inhibit the propagation of HCV.
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Recombinant Poliovirus For The Treatment Of Cancer
view source -
US Patent:7147848, Dec 12, 2006
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Filed:Jun 19, 2002
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Appl. No.:10/175247
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Inventors:Matthias Gromeier - Stony Brook NY, US
Eckard Wimmer - East Setauket NY, US -
Assignee:The Research Foundation of State University of New York - Albany NY
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International Classification:A01N 63/00
C12N 7/00
C12N 7/01
C12N 7/02
C12N 7/04
C07H 21/00 -
US Classification:424 936, 424 931, 424 932, 4352351, 435236, 435239, 536 2372, 536 241
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Abstract:The present invention is directed to non-pathogenic, oncolytic, recombinant polioviruses for the treatment of various forms of malignant tumors. The recombinant polioviruses of the invention are those in which the internal ribosomal entry site (IRES) of the wild type poliovirus was exchanged with the IRES of other picornaviruses, and optionally P1, P3 or the 3′NTR thereof was exchanged with that of poliovirus Sabin type. More particularly, the present invention is directed to the administration of the non-pathogenic, oncolytic, recombinant poliovirus to the tumor directly, intrathecally or intravenously to cause tumor necrosis. The method of the present invention is particularly useful for the treatment of malignant tumors in various organs, such as: breast, colon, bronchial passage, epithelial lining of the gastrointestinal, upper respiratory and genito-urinary tracts, liver, prostate and the brain. Astounding remissions in experimental animals have been demonstrated for the treatment of malignant glioblastoma multiforme, an almost universally fatal neoplasm of the central nervous system.
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Attenuated Viruses Useful For Vaccines
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US Patent:20100209454, Aug 19, 2010
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Filed:Mar 31, 2008
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Appl. No.:12/594173
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Inventors:Eckard Wimmer - East Setauket NY, US
Steve Skiena - Setauket NY, US
Steffen Mueller - Kings Point NY, US
Bruce Futcher - Stony Brook MA, US
Dimitris Papamichail - South Miami FL, US
John Robert Coleman - Blauvelt NY, US
Jeronimo Cello - Port Jefferson NY, US -
International Classification:A61K 39/12
A61P 31/14
A61P 31/16
A61P 31/20
A61P 31/22
A61P 31/18
C12N 7/04 -
US Classification:4242051, 435236
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Abstract:This invention provides an attenuated virus which comprises a modified viral genome containing nucleotide substitutions engineered in multiple locations in the genome, wherein the substitutions introduce synonymous deoptimized codons into the genome. The instant attenuated virus may be used in a vaccine composition for inducing a protective immune response in a subject. The invention also provides a method of synthesizing the instant attenuated virus. Further, this invention further provides a method for preventing a subject from becoming afflicted with a virus-associated disease comprising administering to the subject a prophylactically effective dose of a vaccine composition comprising the instant attenuated virus.
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Attenuated Influenza Viruses And Vaccines
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US Patent:20120269849, Oct 25, 2012
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Filed:Oct 11, 2010
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Appl. No.:13/501045
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Inventors:Eckard Wimmer - East Setauket NY, US
Steve Skiena - Setauket NY, US
Steffen Mueller - Kings Point NY, US
Bruce Futcher - Stony Brook NY, US
Dimitris Papamichail - South Miami FL, US
John Robert Coleman - Blauvelt NY, US
Jeronimo Cello - Port Jefferson NY, US -
International Classification:A61K 39/12
C12N 7/04
A61P 31/12
C12N 15/54 -
US Classification:4242041, 536 232, 435236
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Abstract:The present provides attenuated influenza viruses comprising a modified viral genome containing a plurality of nucleotide substitutions. The nucleotide substitutions result in the rearrangement of preexisting codons of one or more protein encoding sequences and changes in codon pair bias. Substitutions of non-synonymous and synonymous codons may also be included. The attenuated influenza viruses enable production of improved vaccines and are used to elicit protective immune responses.
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Recombinant Poliovirus For The Treatment Of Cancer
view source -
US Patent:6264940, Jul 24, 2001
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Filed:Aug 5, 1998
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Appl. No.:9/129686
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Inventors:Matthias Gromeier - Stony Brook NY
Eckard Wimmer - East Setauket NY -
Assignee:The Research Foundation of State University of New York - Albany NY
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International Classification:A01N 6300
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US Classification:424 932
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Abstract:The present invention is directed to non-pathogenic, oncolytic, recombinant polioviruses for the treatment of various forms of malignant tumors. The recombinant polioviruses of the invention are those in which the internal ribosomal entry site (IRES) of the wild type poliovirus was exchanged with the IRES of other picornaviruses, and optionally P1, P3 or the 3'NTR thereof was exchanged with that of poliovirus Sabin type. More particularly, the present invention is directed to the administration of the non-pathogenic, oncolytic, recombinant poliovirus to the tumor directly, intrathecally or intravenously to cause tumor necrosis. The method of the present invention is particularly useful for the treatment of malignant tumors in various organs, such as: breast, colon, bronchial passage, epithelial lining of the gastrointestinal, upper respiratory and genito-urinary tracts, liver, prostate and the brain. Astounding remissions in experimental animals have been demonstrated for the treatment of malignant glioblastoma multiforme, an almost universally fatal neoplasm of the central nervous system.
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De Novo Cell-Free Synthesis Of Picornavirus
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US Patent:56747292, Oct 7, 1997
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Filed:Jun 30, 1994
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Appl. No.:8/268679
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Inventors:Eckard Wimmer - Stony Brook NY
Akhteruzzaman Molla - Port Jefferson NY
Aniko V. Paul - Setauket NY -
Assignee:Research Foundation of State University of New York - Albany NY
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International Classification:C12N 700
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US Classification:4352351
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Abstract:A process for the de novo synthesis of a picornavirus using a cell-free medium has been developed. The cell-free medium is prepared from a lysate of mammalian cells from which the nuclei and mitochondria has been removed, endogenous mRNA deactivated and supplemented with nucleoside triphosphates, tRNA, amino acids and precursors necessary for generating proteins. The genomic RNA of the picornavirus or rhinovirus is added to the cell-free medium and after incubation at about 30. degree. C. to 40. degree. C. of from about 4 to 24 hours infectious, mature virus particles are formed.
Amazon
Regulation of Gene Expression in Animal Viruses (Nato Science Series A:)
view sourceViruses, being obligatory parasites of their host cells, rely on a vast supply of cellular components for their replication, regardless of whether infection leads to cell death or to the state of persistence. Animal viruses are providing scientists with relatively simple models to study the molecula...
Binding
Paperback
Pages
325
Publisher
Springer
ISBN #
1461362717
EAN Code
9781461362715
ISBN #
2
Molecular Biology Of Picornaviruses (Hb)
view sourceBook by SEMLER, BERT L; WIMMER, ECKARD
Author
BERT L; WIMMER, ECKARD SEMLER
Binding
Hardcover
Publisher
Asm Press
ISBN #
1555812104
EAN Code
9781555812102
ISBN #
1
Cellular Receptors for Animal Viruses (Monograph; No. 28) (Cold Spring Harbor Monograph)
view sourceState University of New York, Stony Brook.Microbiological research, based in part on the 1991 Banbury Conference entitled Receptor-Mediated Virus Entry into Cells. 64 contributors, 46 U.S. Color and halftone illustrations.
Author
Eckard Wimmer
Binding
Hardcover
Pages
526
Publisher
Cold Spring Harbor Laboratory Press
ISBN #
0879694297
EAN Code
9780879694296
ISBN #
4
Viral Proteinases As Targets for Chemotherapy (Current Communications in Cell and Molecular Biology)
view sourceBook by Krausslich, Hans-Georg, Oroszlan, Stephen
Author
Hans-Georg Krausslich, Stephen Oroszlan
Binding
Paperback
Pages
287
Publisher
Cold Spring Harbor Laboratory Pr
ISBN #
0879693355
EAN Code
9780879693350
ISBN #
3
Cellular Receptors for Animal Viruses (Monograph; No. 28) (Cold Spring Harbor Monograph) by Wimmer, Eckard published by Cold Spring Harbor Laboratory Press Hardcover
view sourceBinding
Hardcover
Publisher
Cold Spring Harbor Laboratory Press
ISBN #
5
Wikipedia
Eckard Wimmer
view sourceEckard Wimmer (born 22 May 1936) is a German American virologist, organic chemist and distinguished professor of molecular genetics and microbiology at...
ISBN #
2
Resumes
Isbn (Books And Publications)
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Regulation Of Gene Expression In Animal Viruses
view source -
Author:Eckard Wimmer
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ISBN #:0306444089
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Viral Proteinases As Targets For Chemotherapy
view source -
Author:Eckard Wimmer
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ISBN #:0879693355
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Cellular Receptors For Animal Viruses
view source -
Author:Eckard Wimmer
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ISBN #:0879694297
News
What 60 Minutes Got Right And Wrong On Duke's Polio Virus Trial Against ...
view source- Duke for the last 15 years painstakingly shepherding his studies from lab to clinic. But the German-trained molecular biologist began this work in earnest 25 years ago when he came to the States to work with the renowned virologist, Eckard Wimmer, at the State University of New York at Stony Brook.
- Date: Mar 30, 2015
- Category: Health
- Source: Google
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