Donald G Payan

US Patent:

6455263, Sep 24, 2002

Filed:

Mar 24, 1998

Appl. No.:

09/047119

Inventors:

Donald Payan - Hillsborough CA

Assignee:

Rigel Pharmaceuticals, Inc. - South San Francisco CA

International Classification:

G01N 3353

US Classification:

435 71, 435 72, 435 79, 435DIG 14, 435DIG 40, 435DIG 41, 436518, 436527, 436531, 436 80, 436172

Abstract:

The present invention relates to methods of screening libraries of small molecules such as combinatorial chemical libraries of organic molecules, including peptides and other chemical libraries, for binding to target molecules, using fluoroscence-activated cell sorting (FACS) machines.

US Patent:

6555314, Apr 29, 2003

Filed:

Mar 30, 1998

Appl. No.:

09/050861

Inventors:

Donald Payan - Hillsborough CA

Assignee:

Rigel Pharmaceuticals, Inc. - South San Francisco CA

International Classification:

C12Q 168

US Classification:

435 6, 435 912, 536 231, 536 235, 436536

Abstract:

The present invention is directed to methods for identifying novel compositions which modulate the activity of Toso, and the use of such compositions in diagnosis and treatment of disease.

US Patent:

6737240, May 18, 2004

Filed:

May 24, 2000

Appl. No.:

09/578030

Inventors:

Ziang Xu - South San Francisco CA
Donald Payan - Hillsborough CA

Assignee:

Rigel Pharmaceuticals, Inc. - South San Francisco CA

International Classification:

G01N 3353

US Classification:

435 71, 435 6, 435 4, 435DIG 3, 435DIG 2, 536 234, 536 231, 530300

Abstract:

The invention relates generally to methods of screening for drugs which bind to and/or regulate cellular proteins involved in drug resistance, particularly resistance of tumor cells to chemotherapeutic agents.

US Patent:

6808906, Oct 26, 2004

Filed:

May 8, 2002

Appl. No.:

10/142662

Inventors:

Mary Shen - Newark CA
Simon Yu - Newark CA
Xian Wu - Redwood City CA
Donald Payan - Hillsborough CA

Assignee:

Rigel Pharmaceuticals, Inc. - South San Francisco CA

International Classification:

C12N 1566

US Classification:

435 9141, 435 9151, 4353201, 435325, 43525233, 435489

Abstract:

The present invention provides random cDNA expression vector libraries, comprising expression vectors which comprise random cDNAs positioned in sense orientation. Also provided are random cDNA expression vector libraries, comprising expression vectors which comprise random cDNAs positioned in antisense orientation. Methods for producing these libraries through directional cloning of random cDNAs are also provided. Also provided herein are methods of using these libraries to screen for agents capable of modulating cell phenotype in desirable ways.

US Patent:

6855495, Feb 15, 2005

Filed:

Aug 30, 2000

Appl. No.:

09/651150

Inventors:

Donald Payan - Hillsborough CA, US

Assignee:

Rigel Pharmaceuticals, Inc. - South San Francisco CA

International Classification:

C12Q001/68
G01N033/53
C07H021/02

US Classification:

435 6, 435 721, 435 691, 435 701, 536 231, 536 243

Abstract:

The present invention is directed to methods for identifying novel compositions which modulate the activity of Toso, and the use of such compositions in diagnosis and treatment of disease.

US Patent:

6897031, May 24, 2005

Filed:

Apr 17, 1998

Appl. No.:

09/062330

Inventors:

Joseph Fisher - Belmont CA, US
James Lorens - Menlo Park CA, US
Donald Payan - Hillsborough CA, US
Alexander Rossi - San Francisco CA, US

Assignee:

Rigel Pharmaceuticals, Inc. - South San Francisco CA

International Classification:

G01N033/567

US Classification:

435 721, 424 141, 424406, 435 72, 436164, 436172, 356485, 356492, 356495

Abstract:

Described is a method for screening for alterations in exocytosis of a population of cells. The cells are sorted by a FACS machine by assaying for alterations in at least three of the properties selected from the group consisting of light scattering, fluorescent dye uptake, fluorescent dye release, annexin granule binding, surface granule enzyme activity, and the quantity of granule specific proteins. Methods for screening for bioactive agents capable of modulating exocytosis in a cell are also described. The methods provide for reduced background and increased specificity without increasing the time or steps involved in assaying for exocytosis.

US Patent:

6969584, Nov 29, 2005

Filed:

Jun 12, 1997

Appl. No.:

08/873601

Inventors:

Garry P. Nolan - Menlo Park CA, US
Donald Payan - Hillsborough CA, US

Assignee:

Rigel Pharmaceuticals, Inc. - South San Francisco CA

International Classification:

C12Q001/68

US Classification:

435 6, 435 4, 435 5, 435 72, 435 74, 435 791, 435DIG 3, 435DIG 2

Abstract:

The invention relates to the formation of novel in vivo combinatorial enzyme complexes for use in screening candidate drug agents for bioactivity.

US Patent:

7034145, Apr 25, 2006

Filed:

Sep 3, 2004

Appl. No.:

10/933855

Inventors:

Mary Shen - Newark CA, US
Simon Yu - Newark CA, US
Xian Wu - Redwood City CA, US
Donald Payan - Hillsborough CA, US

Assignee:

Rigel Pharmaceuticals, Inc. - South San Francisco CA

International Classification:

C07H 21/04

US Classification:

536 243, 536 2433

Abstract:

The present invention provides random cDNA expression vector libraries, comprising expression vectors which comprise random cDNAs positioned in sense orientation. Also provided are random cDNA expression vector libraries, comprising expression vectors which comprise random cDNAs positioned in antisense orientation. Methods for producing these libraries through directional cloning of random cDNAs are also provided. Also provided herein are methods of using these libraries to screen for agents capable of modulating cell phenotype in desirable ways.