Daniel Jon Sall - Greenwood IN, US Jolie Anne Bastian - Beech Grove IN, US Cynthia Darshini Jesudason - Indianapolis IN, US Theo Schotten - Vierhufen, DE Gerd Reuhter - Hamburg, DE Don Richard Finley - Greenwood IN, US Freddie Craig Stevens - Indianapolis IN, US Vincent Patrick Rocco - Indianapolis IN, US Patrick Gianpietro Spinazze - Avon IN, US John Xiaoqiang He - Fishers IN, US John Arnold Werner - Indianapolis IN, US William George Trankle - Southport IN, US Andrew Michael Ratz - Indianapolis IN, US
The present invention relates to a β3 adrenergic receptor agonist of formula (I); or a pharmaceutical salt thereof; which is capable of increasing lipolysis and energy expenditure in cells and, therefore, is useful for treating Type 2 diabetes and/or obesity.
2-Oxo-Benzimidazolyl Substituted Ethanolamine Derivatives And Their Use As Βagonists
Cynthia Darshini Jesudason - Indianapolis IN, US Don Richard Finley - Greenwood IN, US
Assignee:
Eli Lilly and Company - Indianapolis IN
International Classification:
C07D 235/24
US Classification:
5483064, 564305
Abstract:
The present invention relates to a βadrenergic receptor agonist of formula I: or a pharmaceutical salt thereof; which is capable of increasing lipolysis and energy expenditure in cells and, therefore, is useful for treating Type 2 diabetes and/or obesity.
Daniel Jon Sall - Greenwood IN, US Jolie Anne Bastian - Beech Grove IN, US Cynthia Darshini Jesudason - Indianapolis IN, US Don Richard Finley - Greenwood IN, US Freddie Craig Stevens - Indianapolis IN, US Vincent Patrick Rocco - Indianapolis IN, US Patrick Gianpietro Spinazze - Avon IN, US John Xiaoqiang He - Fishers IN, US John Arnold Werner - Indianapolis IN, US William George Trankle - Souhtport IN, US Andrew Michael Ratz - Indianapolis IN, US Theo Schotten - Vierhufen, DE Gerd Reuhter - Hamburg, DE
Daniel Jon Sall - Greenwood IN, US Jolie Anne Bastian - Beech Grove IN, US Rushad Eruch Karanjawala - Zionsville IN, US Cynthia Darshini Jesudason - Indianapolis IN, US Theo Schotten - Vierhufen, DE Britta Evers - Hamburg, DE Gerd Reuhter - Hamburg, DE Don Richard Finley - Greenwood IN, US Freddie Craig Stevens - Indianapolis IN, US Vincent Patrick Rocco - Indianapolis IN, US Patrick Gianpietro Spinazze - Avon IN, US John Xiaoqiang He - Fishers IN, US John Arnold Werner - Indianapolis IN, US William George Trankle - Southport IN, US Andrew Michael Ratz - Greenwood IN, US
The present invention relates to a β3 adrenergic receptor agonist of formula (I); or a pharmaceutical salt thereof; which is capable of increasing lipolysis and energy expenditure in cells and, therefore, is useful, e. g. , for treating Type 2 diabetes and/or obesity.
2-Oxo-Benzimidazolyl Substituted Ethanolamine Derivatives And Their Use As Βagonists
Cynthia Darshini Jesudason - Indianapolis IN, US Don Richard Finley - Greenwood IN, US
Assignee:
Eli Lilly and Company - Indianapolis IN
International Classification:
A61K 31/4184 C07D 213/82
US Classification:
514394, 5483064
Abstract:
The present invention relates to a βadrenergic receptor agonist of formula (I), wherein R is C–Calkyl or (C–Ccycloalkyl)C–Calk-di-yl: Ris H, CN, halo; C–Calkyl, C–Chaloalkyl, COR, CONRR, NRCOR, NRR, OR, SR, SOR, S0Ror SONRR; Ris H, halo or C–Calkyl; Ris H or C–Calkyl; Rand Rare independently H or C–Calkyl Ris hydrogen, optionally substituted phenyl or optionally substituted heterocycle; X is absent or is OCHor SCH; Xis absent or C–Calk-di-yl; and Xis absent or is O, S, NH, NHSO, SONH or CH; or a pharmaceutical salt thereof; which is capable of increasing lipolysis and energy expenditure in cells and, therefore, is useful for treating Type 2 diabetes and/or obesity.
Histamine H3 Receptor Agents, Preparation And Therapeutic Uses
Don Richard Finley - Greenwood IN, US Terry Patrick Finn - Geneva, CH Philip Arthur Hipskind - New Palestine IN, US William Joseph Hornback - Fishers IN, US Cynthia Darshini Jesudason - Indianapolis IN, US Takako Takakuwa - Indianapolis IN, US
Assignee:
Eli Lilly and Company - Indianapolis IN
International Classification:
A61K 31/427 C07D 277/20
US Classification:
514365, 548200, 548202, 548204
Abstract:
The present invention provides a novel compound of Formula (I) or a pharmaceutically acceptable salt thereof, having histamine-H3 receptor antagonist or inverse agonist activity, as well as methods for preparing such compounds. In another, embodiment, the invention discloses pharmaceutical compositions comprising compounds of Formula (I) as well as methods of using them to treat obesity, cognitive deficiencies, narcolepsy, and other histamine H3 receptor-related diseases.
Pyrrolidine Derivatives As Histamine H3 Receptor Antagonists
Lisa Selsam Beavers - Franklin IN, US Don Richard Finley - Greenwood IN, US Robert Alan Gadski - Indianapolis IN, US Philip Arthur Hipskind - New Palestine IN, US Cynthia Darshini Jesudason - Indianapolis IN, US Richard Todd Pickard - Noblesville IN, US Freddie Craig Stevens - Indianapolis IN, US Takako Takakuwa - Indianapolis IN, US
Assignee:
Eli Lilly and Company - Indianapolis IN
International Classification:
A61K 31/4439 A61K 31/4025 C07D 401/14 C07D 403/06
US Classification:
514343, 514422, 5462791, 548518
Abstract:
The present invention discloses novel compounds of Formula (I) or pharmaceutically acceptable salts thereof which have histamine-H3 receptor antagonist or inverse agonist activity, as well as methods and intermediates for preparing such compounds. In another embodiment, the invention discloses pharmaceutical compositions comprising compounds of Formula (I) as well as methods of using them to treat obesity, cognitive deficiencies, narcolepsy, and other histamine H3 receptor-related diseases.
Histamine H3 Receptor Agents, Preparation And Therapeutic Uses
Lisa Selsam Beavers - Franklin IN, US Don Richard Finley - Greenwood IN, US Robert Alan Gadski - Indianapolis IN, US Philip Arthur Hipskind - New Palestine IN, US William Joseph Hornback - Fishers IN, US Cynthia Darshini Jesudason - Indianapolis IN, US Richard Todd Pickard - Noblesville IN, US Takako Takakuwa - Indianapolis IN, US Grant Mathews Vaught - Indianapolis IN, US
The present invention discloses novel compounds of Formula I or pharmaceutically acceptable salts thereof which have histamine-H3 receptor antagonist or inverse agonist activity, as well as methods for preparing such compounds. In another embodiment, the invention discloses pharmaceutical compositions comprising compounds of Formula I as well as methods of using them to treat obesity, cognitive deficiencies, narcolepsy, and other histamine H3 receptor-related diseases. (Formula I).
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as only one [public] institution that was taking tuition-fee dollars and putting it into student aid. That was the University of Virginia, which was the first to do it, says Don Finley, a former state secretary of education who now is president of the Virginia Business Higher Education Council. Tw