Dominic G Spinella

US Patent:

6461814, Oct 8, 2002

Filed:

Mar 5, 1999

Appl. No.:

09/263196

Inventors:

Dominic G. Spinella - La Costa CA 92009

International Classification:

C12Q 168

US Classification:

435 6, 435 911, 435183, 4353201, 536 235

Abstract:

This invention provides an rapid, artifact free, improved method of obtaining short DNA âtagâ or arrays thereof, allowing for determination of the relative abundance of a gene transcript within a given mRNA population and is useful to identify patterns of gene transcription, as well as identify new genes.

US Patent:

6642353, Nov 4, 2003

Filed:

Sep 20, 2000

Appl. No.:

09/646691

Inventors:

Stephen J. McConnell - San Diego CA
Dominic G. Spinella - La Costa CA

Assignee:

Chugai Seiyaku Kabushiki Kaisha - Tokyo

International Classification:

C07K 1400

US Classification:

530300, 530326, 435375, 930 90

Abstract:

Clones isolated from phage display libraries that bound to an erythropoietin (EPO) receptor probe are disclosed. Peptides encoded by sequences of those clones that bound to the EPO receptor are disclosed. A 12-mer amino acid consensus sequence, CXXGWVGXCXXW (where X represents one of many amino acids), common to the peptides that bound to the EPO receptor, but unrelated to the primary structure of EPO, is disclosed.

US Patent:

20040110757, Jun 10, 2004

Filed:

Sep 22, 2003

Appl. No.:

10/472631

Inventors:

Thomas Arrhenius - Del Mar CA, US
Yujin Huang - San Diego CA, US
Lin Zhang - San Diego CA, US
Rossy Serafimov - Metz, FR
Alex Nadzan - Encinitas CA, US
Dominic Spinella - Santee CA, US

International Classification:

A61K031/53
A61K031/506
A61K031/4439
A61K031/4245
A61K031/4184

US Classification:

514/241000, 514/256000, 514/338000, 514/339000, 514/364000, 514/394000, 514/416000

Abstract:

This invention is a method of treatment and prophylaxis of diseases regulatable by angiogenesis, including novel FLT-1 ligands and pharmaceutical compositions containing them, useful in the methods for the treatment and prophylaxis of these diseases, as well as intermediates and processes useful for the preparation of the compounds of the invention as claimed.

US Patent:

59687843, Oct 19, 1999

Filed:

Jan 15, 1997

Appl. No.:

8/784208

Inventors:

Dominic G. Spinella - La Costa CA
Fereydoun G. Sajjadi - Encinitas CA

Assignee:

Chugai Pharmaceutical Co., Ltd. - Tokyo

International Classification:

C12P 1934
C12N 1564

US Classification:

435 911

Abstract:

The present invention provides novel methods for identifying gene expression patterns in mRNA populations. The methods are useful for determining differential gene expression among various cells or tissues, including cells or tissues of a target organism. The invention also provides methods of determining the frequency of gene expression in mRNA populations, thus providing a method of comparing gene expression frequency among various cells or tissues. The present invention also provides methods for isolating genes corresponding to tag sequences identified according to the methods of the present invention. Furthermore, sequences that are identified according to the present invention may be used to diagnose the presence of disease.

US Patent:

58663410, Feb 2, 1999

Filed:

Apr 3, 1996

Appl. No.:

8/627151

Inventors:

Dominic Gregory Spinella - San Diego CA
Kathleen Ann Becherer - San Diego CA
Steven Joel Brown - San Diego CA

Assignee:

Chugai Pharmaceutical Co., Ltd. - Tokyo

International Classification:

G01N 3353

US Classification:

435 71

Abstract:

A method of screening for binding partners of a specific molecule. The method employs a chimeric protein having at least two different binding regions; one containing at least a portion of the specific molecule or an analog thereof, and the other containing a binding region of an immunoglobulin chain. In a preferred embodiment, the method is used for rapidly screening member compounds of a combinatorial library for potential biological activity.