Dmitri G Wiederschain from Brookline, MA, age 54

Us Patents

Pharmaceutical Compositions Comprising Troponin Subunits, Fragments And Homologs Thereof And Methods Of Their Use To Inhibit Angiogenesis
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US Patent:

6465431, Oct 15, 2002
Filed:

Nov 17, 1999
Appl. No.:

09/442099
Inventors:

Richard M. Thorn - North Easton MA
Marc E. Lanser - Dover MA
Marsha A. Moses - Brookline MA
Dmitri G. Wiederschain - Brookline MA
Assignee:

Boston Life Sciences, Inc. - Boston MA
Childrens Medical Center Corporation - Boston MA
International Classification:

A61K 3808
US Classification:

514 16, 530328
Abstract:

The present invention relates to pharmaceutical compositions comprising therapeutically effective amounts of troponin C, I or T subunits, fragments, or homologs thereof, for the treatment of diseases or disorders involving abnormal angiogenesis and methods of use thereof.

Pharmaceutical Compositions Comprising Recombinant Troponin Subunits
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US Patent:

6589936, Jul 8, 2003
Filed:

Jul 7, 2000
Appl. No.:

09/612421
Inventors:

Richard M. Thorn - North Easton MA
Marc E. Lanser - Dover MA
Marsha A. Moses - Brookline MA
Dmitri G. Wiederschain - Brookline MA
Assignee:

Childrens Medical Center Corporation - Boston MA
International Classification:

A61K 3800
US Classification:

514 12, 514 2, 530350, 435 691, 435 701
Abstract:

The present invention relates to pharmaceutical compositions comprising therapeutically effective amounts of recombinant troponin C, I or T subunits for the treatment of diseases or disorders involving abnormal angiogenesis.

Non-Invasive Enzyme Screen For Cancer
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US Patent:

6811995, Nov 2, 2004
Filed:

Dec 22, 1999
Appl. No.:

09/469637
Inventors:

Marsha A. Moses - Brookline MA
Michael R. Freeman - Boston MA
Dmitri Wiederschain - Brookline MA
Assignee:

Childrens Medical Center Corporation - Boston MA
International Classification:

C12Q 137
US Classification:

435 23, 435 24
Abstract:

The present invention relates to non-invasive methods for facilitating the diagnosis of a subject as having cancer. The described methods involve detecting the presence of a matrix metalloproteinase in urine samples obtained from a patient and correlating the presence or absence of the matrix metalloproteinase with the presence or absence of cancer. Methods for monitoring the prognosis of a patient by detection of matrix metalloproteinase are also provided.

Methods Of Inhibiting Angiogenesis With Fragments And Homologs Of Troponin Subunit I
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US Patent:

7078385, Jul 18, 2006
Filed:

Jun 18, 2002
Appl. No.:

10/176416
Inventors:

Richard M. Thorn - North Easton MA, US
Marc E. Lanser - Dover MA, US
Marsha A. Moses - Brookline MA, US
Dmitri G. Wiederschain - Brookline MA, US
Assignee:

Boston Life Sciences, Inc. - Boston MA
Children's Medical Center Corporation - Boston MA
International Classification:

A61K 38/08
C07K 7/06
US Classification:

514 16, 514 2, 514 12, 530328
Abstract:

The present invention relates to methods of inhibiting angiogenesis associated with a disease or disorder with peptides homologous to amino acid residues 130–137 or 132–139 of human troponin subunit I.

Pharmaceutical Compositions Comprising Fragments And Homologs Of Troponin Subunits
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US Patent:

7393829, Jul 1, 2008
Filed:

Jul 9, 2002
Appl. No.:

10/192806
Inventors:

Marsha A Moses - Brookline MA, US
Dmitri G. Wiederschain - Cambridge MA, US
Assignee:

Children's Medical Center Corporation - Boston MA
International Classification:

A61K 38/04
C07K 14/435
US Classification:

514 12, 530324, 514 21
Abstract:

The present invention relates to pharmaceutical compositions comprising therapeutically effective amounts of fragments or homologs of troponin C, I or T subunits for the treatment of diseases or disorders involving abnormal angiogenesis.

Methods Of Inhibiting Angiogenesis With Fragments And Homologs Of Troponin Subunit 1
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US Patent:

7452866, Nov 18, 2008
Filed:

Jan 5, 2006
Appl. No.:

11/327174
Inventors:

Richard M. Thorn - North Easton MA, US
Mark A. Lanser - Dover MA, US
Marsha A. Moses - Brookline MA, US
Dmitri G. Wiederschain - Brighton MA, US
Assignee:

Children's Medical Center Corporation - Boston MA
Alseres Pharmaceuticals, Inc. - Hopkinton MA
International Classification:

A61K 38/16
C07K 14/00
US Classification:

514 12, 514 2, 530324
Abstract:

The present invention relates to methods of inhibiting angiogenesis associated with a disease or disorder with peptides homologous to amino acid residues 130-137 or 132-139 of human troponin subunit I.

Non-Invasive Enzyme Screen For Cancer
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US Patent:

20030215900, Nov 20, 2003
Filed:

Apr 16, 2003
Appl. No.:

10/414989
Inventors:

Marsha Moses - Brookline MA, US
Michael Freeman - Boston MA, US
Dmitri Wiederschain - Brookline MA, US
International Classification:

G01N033/574
C12Q001/37
US Classification:

435/023000, 435/007230
Abstract:

Methods and kits for diagnosing the presence of and prognosing the appearance of tissue remodelling-associated conditions, involving the presence of enzymes in a biological sample, are disclosed. In particular, the method pertains to diagnosing the presence of or prognosing appearance of cancer, metastatic cancer, and obstructive and degenerative conditions.

Non-Invasive Enzyme Screen For Tissue Remodeling Associated Conditions
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US Patent:

20070015227, Jan 18, 2007
Filed:

Sep 21, 2006
Appl. No.:

11/524620
Inventors:

Marsha Moses - Brookline MA, US
Michael Freeman - Boston MA, US
Dmitri Wiederschain - Brookline MA, US
Assignee:

Children's Medical Center Corporation - Boston MA
International Classification:

G01N 33/53
US Classification:

435007920
Abstract:

Methods and kits for diagnosing the presence of and prognosing the appearance of tissue remodelling-associated conditions, involving the presence of enzymes in a biological sample, are disclosed. In particular, the method pertains to diagnosing the presence of or prognosing appearance of cancer, metastatic cancer, and obstructive and degenerative conditions.

Resumes

Global Head Of Immuno-Oncology Research Therapeutic Area

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Location:

145 Englewood Ave, Brighton, MA 02135

Industry:

Pharmaceuticals

Work:

Sanofi - Cambridge, MA since Jul 2010
Principal Research Investigator/ Laboratory Head, Oncology Division

Education:

Harvard University 1999 - 2003
Harvard University 1996 - 1998
First Moscow State Medical University named after I.M. Sechenov 1988 - 1992

Skills:

Drug Discovery
Oncology
Clinical Development
In Vivo
Cancer
Drug Development
Life Sciences
Cancer Research
In Vitro
Pharmacology
Pk/Pd
Metabolism
Molecular and Cellular Biology
Rna Therapeutics
Immuno Oncology

Languages:

English
Russian

Dmitri G Wiederschain

Dmitri Wiederschain Phones & Addresses

Work

Education

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Us Patents

Pharmaceutical Compositions Comprising Troponin Subunits, Fragments And Homologs Thereof And Methods Of Their Use To Inhibit Angiogenesis

Pharmaceutical Compositions Comprising Recombinant Troponin Subunits

Non-Invasive Enzyme Screen For Cancer

Methods Of Inhibiting Angiogenesis With Fragments And Homologs Of Troponin Subunit I

Pharmaceutical Compositions Comprising Fragments And Homologs Of Troponin Subunits

Methods Of Inhibiting Angiogenesis With Fragments And Homologs Of Troponin Subunit 1

Non-Invasive Enzyme Screen For Cancer

Non-Invasive Enzyme Screen For Tissue Remodeling Associated Conditions

Resumes

Global Head Of Immuno-Oncology Research Therapeutic Area