Dimitrios M Zarkadas

US Patent:

7811381, Oct 12, 2010

Filed:

Jun 11, 2007

Appl. No.:

11/811557

Inventors:

Kamalesh K. Sirkar - Bridgewater NJ, US
Dimitrios Zarkadas - Fanwood NJ, US

International Classification:

C30B 7/14

US Classification:

117 68, 117 69, 117 70

Abstract:

Antisolvent crystallization systems and methods are provided that employ porous hollow fiber membranes. The porous hollow fiber membrane includes a plurality of porous hollow fibers positioned within a shell, each porous hollow fiber defining a lumen side and shell side. A crystallizing solution is introduced to one side of the hollow fibers and an antisolvent is introduced to the other side of the fibers, in either cocurrent or countercurrent flow. One of the antisolvent and the crystallizing solution permeates in part through the porous hollow fiber membrane to the other side and crystals are formed thereby. Permeation of the antisolvent or the crystallizing solution establishes advantageous radial mixing that facilitates crystal formation of a desired size distribution. Downstream mixing, e. g. , a completely stirred tank or a static mixer, may be employed to further improve crystallization operations.

US Patent:

7919505, Apr 5, 2011

Filed:

Jul 10, 2007

Appl. No.:

11/775383

Inventors:

Pauline C. Ting - New Providence NJ, US
Joe F. Lee - Brooklyn NY, US
Kung-I Feng - Basking Ridge NJ, US
Michael R. Reeder - Skillman NJ, US
Scott T. Trzaska - Raritan NJ, US
Man Zhu - Clark NJ, US
Chen Mao - New Providence NJ, US
Dimitar L. Filipov - Elizabeth NJ, US
Dimitrios N. Zarkadas - Fanwood NJ, US

Assignee:

Schering Corporation - Kenilworth NJ

International Classification:

C07D 215/38
A61K 31/04

US Classification:

514312, 546159, 546163

Abstract:

The present invention relates to the compound of the formula.

US Patent:

8420122, Apr 16, 2013

Filed:

Apr 8, 2008

Appl. No.:

12/080989

Inventors:

Dimitrios Zarkadas - Fanwood NJ, US
Vincenzo Liotta - Glen Ridge NJ, US
Christopher Stanley Pridgen - Union City NJ, US
Wing-Kee Philip Cho - Princeton NJ, US
Zhihui Qiu - Bridgewater NJ, US

Assignee:

Merck Sharp & Dohme Corp. - Rahway NJ

International Classification:

A61K 9/16
A61K 31/403
C07D 209/52

US Classification:

424489, 514412, 548515

Abstract:

The present invention provides a method of continuous precipitation and isolation of an amorphous solid particulate form of 3-[2-(3-tert-Butyl-ureido)-3,3-dimethyl-butyryl]-6,6-dimethyl-3-aza-bicyclo[3. 1. 0]hexane-2-carboxylic acid (2-carbamoyl-1-cyclobutylmethyl-2-oxo-ethyl)-amide having controlled physical properties. The present invention provides also pharmaceutical formulations comprising the precipitated compound.

US Patent:

20060096525, May 11, 2006

Filed:

Oct 26, 2005

Appl. No.:

11/259184

Inventors:

Kamalesh Sirkar - Bridgewater NJ, US
Dimitrios Zarkadas - Kearny NJ, US

International Classification:

H01L 21/322
C30B 11/00

US Classification:

117200000, 117206000, 117002000

Abstract:

A solid hollow fiber cooling crystallizer and method for crystallizing aqueous and organic solutions are provided. The solid hollow fiber crystallizer (SHFC) for carrying out cooling crystallization of inorganic/organic microsolutes/macrosolutes from solution generally includes a bundle of non-porous hollow fibers mounted within a shell where a feed solution for crystallization flows through the lumen side of the hollow fibers and a cooling solution flows through the shell side to form nuclei and subsequently crystals in the feed solution at a temperature below its saturation temperature. The solid hollow fiber crystallizer may be combined with a mixing device, such as a completely stirred tank or static mixer, to further effectuate crystallization. The solid hollow fiber crystallizer may be operated in a number of modes including feed recycle mode, once through mode, SHFC-in-line static mixer in series mode, and SHFC-CST in series mode. The advantages of solid hollow fiber cooling crystallization in comparison to conventional crystallization processes include improved temperature control between crystallizing solution and coolant, higher nucleation rates, improved control of crystal size and crystal size distribution, smaller crystal size, capability for decoupling crystal nucleation and crystal growth, decreased fouling of process equipment, and improved process scale-up.

US Patent:

20070107884, May 17, 2007

Filed:

Oct 25, 2006

Appl. No.:

11/586150

Inventors:

Kamalesh Sirkar - Bridgewater NJ, US
Alexander Korikov - Uniondale NY, US
Praveen Kosaraju - Harrison NJ, US
Dimitrios Zarkadas - Fanwood NJ, US

International Classification:

F28F 13/18

US Classification:

165133000, 165158000

Abstract:

Heat exchange systems are provided that include one or more polymeric hollow fibers. Exemplary hollow fibers are asymmetric and include a microporous wall and a dense skin formed thereon, thereby preventing liquid transmission and/or contamination through the wall of the hollow fiber while simultaneously enhancing heat transfer based on the presence of liquid molecules within the porous substructure of the hollow fiber. The hollow fibers may be employed in a variety of heat transfer-related commercial/industrial applications, including solvent-aqueous systems, organic-aqueous systems, organic-organic systems, desalination applications, solar heating applications, applications in the chemical industry, applications in the biomedical industry, and applications in the biotechnology or pharmaceutical industry, e.g., extracorporeal blood oxygenation systems. Heat transfer systems wherein steam is advantageously condensed on a first side of a polymeric, hollow fiber-based heat exchanger are also provided. The condensed steam provides energy that may be used to heat water and/or other liquids that flow on a second side of the polymeric, hollow fibers.

US Patent:

20080193518, Aug 14, 2008

Filed:

Apr 26, 2007

Appl. No.:

11/789915

Inventors:

Dimitrios Zarkadas - Fanwood NJ, US
Vincenzo Liotta - Glen Ridge NJ, US
Christopher Stanley Pridgen - Union City NJ, US
Wing-Kee Philip Cho - Princeton NJ, US
Zhihui Qiu - Bridgewater NJ, US

International Classification:

A61K 9/48
C07D 209/00
A61K 9/14
A61P 43/00
A61K 31/40

US Classification:

424451, 548452, 424499, 514412

Abstract:

The present invention provides a method of continuous precipitation and isolation of an amorphous solid particulate form of 3-[2-(3-tert-Butyl-ureido)-3,3-dimethyl-butyryl]-6,6-dimethyl-3-aza-bicyclo[3.1.0]hexane-2-carboxylic acid (2-carbamoyl-1-cyclobutylmethyl-2-oxo-ethyl)-amide having controlled physical properties. The present invention provides also pharmaceutical formulations comprising the precipitated compound.

US Patent:

20090000080, Jan 1, 2009

Filed:

May 2, 2008

Appl. No.:

12/114315

Inventors:

Kamalesh K. Sirkar - Bridgewater NJ, US
Dimitrios Zarkadas - Kearny NJ, US

Assignee:

NEW JERSEY INSTITUTE OF TECHNOLOGY - Newark NJ

International Classification:

B01D 9/02

US Classification:

23301, 23295 R

Abstract:

A solid hollow fiber cooling crystallizer and method for crystallizing aqueous and organic solutions are provided. The solid hollow fiber crystallizer (SHFC) for carrying out cooling crystallization of inorganic/organic microsolutes/macrosolutes from solution generally includes a bundle of non-porous hollow fibers mounted within a shell where a feed solution for crystallization flows through the lumen side of the hollow fibers and a cooling solution flows through the shell side to form nuclei and subsequently crystals in the feed solution at a temperature below its saturation temperature. The solid hollow fiber crystallizer may be combined with a mixing device, such as a completely stirred tank or static mixer, to further effectuate crystallization. The solid hollow fiber crystallizer may be operated in a number of modes including feed recycle mode, once through mode, SHFC-in-line static mixer in series mode, and SHFC-CST in series mode. The advantages of solid hollow fiber cooling crystallization in comparison to conventional crystallization processes include improved temperature control between crystallizing solution and coolant, higher nucleation rates, improved control of crystal size and crystal size distribution, smaller crystal size, capability for decoupling crystal nucleation and crystal growth, decreased fouling of process equipment, and improved process scale-up.

US Patent:

20100324295, Dec 23, 2010

Filed:

Jul 3, 2008

Appl. No.:

12/668192

Inventors:

Timothy D. Cutarelli - Clinton NJ, US
Dimitar L. Filipov - San Francisco CA, US
Christopher Stanley Pridgen - Union City NJ, US
Michael R. Reeder - Skillman NJ, US
Kelvin H. Yong - Lyndhurst NJ, US
Dimitrios N. Zarkadas - Fanwood NJ, US

International Classification:

C07D 413/14
C07D 413/02

US Classification:

546176

Abstract:

The present invention relates a process for the preparation of a compound of the formula:wherein R, R, R, Rand Rare as described herein. The compounds are inhibitors of phosphodiesterase 4 (PDE4).

Address:

364 North Ave, Fanwood, NJ 07023

VIN:

3N1AB61E88L674829

Make:

NISSAN

Model:

SENTRA

Year:

2008