Dhiru B Vashi from 10 Cambridge Way, W Windsor Township, NJ 08550, age 83, Phone: 609 275-0593

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Tricyclic Derivatives, Compositions And Methods Of Use
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US Patent:

55389864, Jul 23, 1996
Filed:

Dec 6, 1993
Appl. No.:

8/162744
Inventors:

Pauline C. Ting - New Providence NJ
Daniel M. Solomon - Edison NJ
Richard J. Friary - Bridgewater NJ
Frank J. Villani - Fairfield NJ
John J. Piwinski - Parsippany NJ
Joe F. Lee - Brooklyn NY
Dhiru B. Vashi - Princeton Junction NJ
Assignee:

Schering Corporation - Kenilworth NJ
International Classification:

C07D31300
C07C23300
C07C21100
A61K 3144
A61K 3135
A61K 31138
A61K 3141
US Classification:

514337
Abstract:

Disclosed are compounds of Formula I: ##STR1## or a pharmaceutically acceptable salt or solvate thereof, wherein: R. sup. 3 is alkyl, alkenyl, alkynyl, aryl, alkaryl, aralkyl, cycloalkyl, acyloxymethyl, alkoxy, alkoxymethyl, or alkyl substituted with cycloalkyl; R. sup. 4 is H, alkyl, alkenyl, alkoxy, or --OH. Also disclosed are pharmaceutical compositions containing compounds of Formula I, methods for inhibiting tumor necrosis factor-. alpha. and methods for treating septic shock, inflammation, or allergic disease by administering a compound of Formula I.

N-((2-Nitro)Phenyl)-N' (Organic Acid) Guanidine Anthelmintics
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US Patent:

47014474, Oct 20, 1987
Filed:

Sep 23, 1983
Appl. No.:

6/535445
Inventors:

Dhiru B. Vashi - Wharton NJ
Jeffrey N. Clark - New Egypt NJ
Neil A. Lindo - New Providence NJ
Assignee:

Schering Corporation - Kenilworth NJ
International Classification:

A01N 4354
A01N 4102
C07C14116
C07C14355
US Classification:

514 85
Abstract:

This invention relates to organic acid-substituted guanidine compounds. Also disclosed are methods for preparing the compounds, compositions containing them, and methods for their use as anthelmintics.

Organic Acid-Substituted Guanidine Anthelmintics
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US Patent:

47230290, Feb 2, 1988
Filed:

Sep 23, 1983
Appl. No.:

6/535019
Inventors:

Dhiru B. Vashi - Wharton NJ
Jeffrey N. Clark - New Egypt NJ
Neil A. Lindo - New Providence NJ
Assignee:

Schering Corporation - Kenilworth NJ
International Classification:

C07C14943
US Classification:

560 13
Abstract:

This invention relates to organic acid-substituted guanidine compounds. Also disclosed are methods for preparing the compounds, compositions containing them, and methods for their use as anthelmintics.

Synthesis Of 3-Amino-2-Methylbenzotrifluoride
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US Patent:

48311936, May 16, 1989
Filed:

Jun 19, 1987
Appl. No.:

7/064891
Inventors:

Joseph F. Lamendola - Lawrenceville NJ
Dhiru Vashi - Princeton Junction NJ
Robert G. Tyson - Prestatyn, GB7
Assignee:

Schering Corporation - Kenilworth NJ
International Classification:

C07C 8511
C07C 7910
US Classification:

564417
Abstract:

This invention relates to a novel process for preparing 3-amino-2-methylbenzotrifluoride from benzotrifluoride. The process comprises nitrating benzotrifluoride to form 3-nitrobenzotrifluoride, reacting this compound with trimethyl sulphoxonium halide to form 3-nitro-2-methylbenzotrifluoride and reducing the nitro group to an amino group.

Process For Preparing Intermediates To Florfenicol
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US Patent:

56633610, Sep 2, 1997
Filed:

Aug 19, 1996
Appl. No.:

8/699271
Inventors:

James C. Towson - Clinton NJ
Dhiru B. Vashi - Princeton Junction NJ
Assignee:

Schering Corporation - Kenilworth NJ
International Classification:

C07D26328
US Classification:

548233
Abstract:

A process for preparing a compound of formula I ##STR1## wherein R and R" are as described herein. Compounds of formula I are useful as intermediates in the preparation of florfenicol.

Dhiru B Vashi