Abstract:
Novel non-steroidal compounds are provided which are useful in treating diseases or disorders associated with modulation of the glucocorticoid receptor, AP-1, and/or NF-κB activity, including metabolic and inflammatory and immune diseases or disorders, having the structure of formula (I): an enantiomer, diastereomer, or taυtomer thereof, or a prodrug ester thereof, or a pharmaceutically-acceptable salt thereof, in which: Z is heterocyclo or heteroaryl; •A is a S- to 8-membered carbocyclic ring or a S- to 8-membered heterocyclic ring; Band Brings are pyridyl rings, wherein the Band Brings are each fused to the A ring and the Bring is optionally substituted by one to three groups which are the same or different and are independently selected from R, R, and R, and the Bring is optionally substituted by one to three groups which are the same or different and are independently selected from R, R, and RJ, J, and Jare at each occurrence the same or different and are independently -AQA-; Q is a bond, O, S, S(O), or S(O); Aand Aare the same or different and are at each occurrence independently selected from a bond, Calkylene, substituted Calkylene, Calkenylene, and substituted Calkenylene, provided that Aand Aare chosen so that ring A is a 5- to 8-membered carbocyclic or heterocyclic ring; Rto Rare as defined herein.