David Edward Uehling from 3909 Collander Dr, Durham, NC 27707, age 64, Phone: 919 489-2781

Phenethanolamine Derivatives, Compositions, And Their Use As Agonists At Atypical Beta-Adrenoreceptors
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US Patent:

7034053, Apr 25, 2006
Filed:

Dec 17, 2001
Appl. No.:

10/470860
Inventors:

David N. Deaton - Durham NC, US
Barry George Shearer - Durham NC, US
David Edward Uehling - Durham NC, US
Assignee:

SmithKline Beecham Corporation - Philadelphia PA
International Classification:

A61K 31/381
A61K 31/34
C07D 333/38
C07D 333/22
C07D 307/02
US Classification:

514448, 514471, 549 71, 549 72, 549 73, 549484, 549486
Abstract:

The present invention disclosed compounds of Formula I. The present invention also discloses beta-3 agonists of formula I and methods for treating beta-3 mediated diseases and condition using the compounds of formula I, in particular methods for treating diabetes or obesity.

2-Pyrimidinyl Pyrazolopyridine Erbb Kinase Inhibitors
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US Patent:

7807673, Oct 5, 2010
Filed:

Dec 4, 2006
Appl. No.:

12/095762
Inventors:

David Edward Uehling - Durham NC, US
Robert Dale Hubbard - Durham NC, US
Alex Gregory Waterson - Durham NC, US
Kimberly Petrov - Durham NC, US
Neil Bifulco, Jr. - Durham NC, US
Joseph Wendell Wilson - Durham NC, US
Jennifer Gabriel Badiang - Durham NC, US
Mul Cheung - Collegeville PA, US
Mariko Yamabe - Tokyo, JP
Assignee:

GlaxoSmithKline LLC - Philadelphia PA
International Classification:

C07D 471/04
A61K 31/437
US Classification:

5142358, 51425214, 514275, 544122, 544295, 544331
Abstract:

The present invention provides 2-pyrimidinyl pyrazolopyridine compounds, compositions containing the same, as well as processes for the preparation and their use as pharmaceutical agents.

2-Pyrimidinyl Pyrazolopyridine Erbb Kinase Inhibitors
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US Patent:

7812022, Oct 12, 2010
Filed:

Dec 6, 2005
Appl. No.:

11/721504
Inventors:

David Edward Uehling - Durham NC, US
Kirk Lawrence Stevens - Durham NC, US
Scott Howard Dickerson - Durham NC, US
Alex Gregory Waterson - Durham NC, US
Philip Anthony Harris - Durham NC, US
Douglas McCord Sammond - Durham NC, US
Robert Dale Hubbard - Lindenhurst IL, US
Holly Kathleen Emerson - Durham NC, US
Joseph W. Wilson - Durham NC, US
Assignee:

GlaxoSmithKline LLC - Philadelphia PA
International Classification:

C07D 471/04
A61K 31/437
US Classification:

5142358, 51425214, 514275, 544122, 544295, 544331
Abstract:

The present invention provides 2-pyrimidinyl pyrazolopyridine compounds, compositions containing the same, as well as processes for the preparation and their use as pharmaceutical agents.

Imidazopyridine Kinase Inhibitors
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US Patent:

8093239, Jan 10, 2012
Filed:

May 28, 2008
Appl. No.:

12/128099
Inventors:

Kevin Kuntz - Durham NC, US
David Edward Uehling - Durham NC, US
Alex Gregory Waterson - Durham NC, US
Kyle Allen Emmitte - Durham NC, US
Kirk Stevens - Durham NC, US
John Brad Shotwell - Durham NC, US
Stephon Cornell Smith - Durham NC, US
Kristen E. Nailor - Durham NC, US
James M. Salovich - Durham NC, US
Brian John Wilson - Durham NC, US
Mui Cheung - King of Prussia PA, US
Robert Anthony Mook - Durham NC, US
Erich W. Baum - Durham NC, US
Ganesh Moorthy - Collegeville PA, US
Assignee:

GlaxoSmithKline LLC - Philadelphia PA
International Classification:

A61K 31/55
A61K 31/505
A61K 31/497
A61K 31/535
C07D 243/08
C07D 413/14
C07D 403/14
C07D 239/02
US Classification:

514218, 5142332, 51425218, 514275, 540575, 544122, 544295, 544297
Abstract:

The present invention provides imidazopyridine compounds, compositions containing the same, as well as processes for the preparation and methods for their use as pharmaceutical agents.

Benzene Sulfonamide Thiazole And Oxazole Compounds
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US Patent:

8415345, Apr 9, 2013
Filed:

May 4, 2009
Appl. No.:

12/991004
Inventors:

George Adjabeng - Durham NC, US
Jerry Leroy Adams - Collegeville PA, US
Scott Howard Dickerson - Durham NC, US
Keith Hornberger - Mount Sinai NY, US
Neil W. Johnson - Collegeville PA, US
Kevin Kuntz - Durham NC, US
Kimberly Petrov - Durham NC, US
Jeffrey M. Ralph - Collegeville PA, US
Tara Renae Rheault - Durham NC, US
Gregory Schaaf - Durham NC, US
John Stellwagen - Durham NC, US
Xinrong Tian - Collegeville PA, US
David E. Uehling - Durham NC, US
Alex G. Waterson - Durham NC, US
Brian Wilson - Durham NC, US
Assignee:

Glaxo SmithKline LLC - Philadelphia PA
International Classification:

C07D 403/14
A61K 31/505
US Classification:

5142278, 5142358, 51425214, 514275, 544 60, 544122, 544295, 544331
Abstract:

The present invention provides thiazole sulfonamide and oxazole sulfonamide compounds, compositions containing the same, as well as processes for the preparation and methods for their use as pharmaceutical agents.

Thienopyrimidine Compounds As Protein Tyrosine Kinase Inhibitors
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US Patent:

20050009845, Jan 13, 2005
Filed:

Dec 13, 2002
Appl. No.:

10/499247
Inventors:

Thomas Caferro - Durham NC, US
Stanley Chamberlain - Durham NC, US
Kelly Donaldson - Durham NC, US
Philip Harris - Durham NC, US
Michael Gaul - Yardley PA, US
David Uehling - Durham NC, US
Dana Vanderwall - Durham NC, US
International Classification:

A61K031/519
C07D498/02
US Classification:

514260100, 544279000
Abstract:

The present invention relates to thienopyrmidine compounds of formula (I) (one of Aand Ais S and the other is CH), salts thereof, as well as use and preparation of the same. These compounds are inhibitors of various protein tyrosine kinases (PTKs) of the ErbB family and consequently are useful in the treatment of disorders mediated by aberrant activity of such kinases.

Chemical Compounds
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US Patent:

20060148887, Jul 6, 2006
Filed:

Feb 21, 2006
Appl. No.:

11/358601
Inventors:

David Deaton - Durham NC, US
Barry Shearer - Durham NC, US
David Uehling - Durham NC, US
International Classification:

A61K 31/381
A61K 31/34
US Classification:

514448000, 514471000
Abstract:

The present invention discloses compounds of Formula I. The present invention also discloses beta-3 agonists of formula I and methods for treating beta-3 mediated diseases and condition using the compounds of formula I, in particular methods for treating diabetes or obesity.

Benzene Sulfonamide Thiazole And Oxazole Compounds
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US Patent:

20090298815, Dec 3, 2009
Filed:

May 4, 2009
Appl. No.:

12/434963
Inventors:

Jerry Leroy Adams - Collegeville PA, US
Scott Howard Dickerson - Durham NC, US
Neil W. Johnson - Collegeville PA, US
Kevin Kuntz - Durham NC, US
Kimberly Petrov - Durham NC, US
Jeffrey M. Ralph - Collegeville PA, US
Tara Renae Rheault - Durham NC, US
Gregory Schaaf - Durham NC, US
John Stellwagen - Durham NC, US
Xinrong Tian - Collegeville PA, US
David Edward Uehling - Durham NC, US
Alex Gregory Waterson - Durham NC, US
Brian Wilson - Durham NC, US
International Classification:

A61K 31/506
C07D 417/04
C07D 417/14
A61K 31/5377
A61K 31/541
A61P 35/00
US Classification:

5142278, 544331, 544122, 544295, 544 582, 514275, 5142358, 51425219
Abstract:

The present invention provides thiazole sulfonamide and oxazole sulfonamide compounds, compositions containing the same, as well as processes for the preparation and methods for their use as pharmaceutical agents.