David V Scarpetti

US Patent:

55413285, Jul 30, 1996

Filed:

Apr 3, 1995

Appl. No.:

8/415385

Inventors:

Timothy L. Stuk - Lindenhurst IL
Michael S. Allen - Silver Lake WI
Anthony R. Haight - Mundelein IL
Francis A. Kerdesky - Grayslake IL
Denton C. Langridge - Wildwood IL
M. Robert Leanna - Grayslake IL
Linda M. Lijewski - Milwaukee WI
Laura Melcher - Deerfield IL
Howard E. Morton - Gurnee IL
Daniel W. Norbeck - Crystal Lake IL
Daniel S. Reno - Kenosha WI
Timothy A. Robbins - Gurnee IL
Hing L. Sham - Mundelein IL
Thomas J. Sowin - Grayslake IL
Chen Zhao - Gurnee IL
David Scarpetti - Baltimore MD

Assignee:

Abbott Laboratories - Abbott Park IL

International Classification:

C07C25178
C07C22114
C07C20944

US Classification:

546 99

Abstract:

A substantially pure compound of formula: ##STR1## wherein R. sub. 6 and R. sub. 7 are independently selected from ##STR2## wherein R. sub. a and R. sub. b are independently selected from hydrogen, loweralkyl and phenyl and R. sub. c, R. sub. d and R. sub. e are independently selected from hydrogen, loweralkyl, trifluoromethyl, alkoxy, halo and phenyl; and ##STR3## wherein the naphthyl ring is unsubstituted or substituted with one, two or three substitutents independently selected from loweralkyl, trifluoromethyl, alkoxy and halo; or R. sub. 6 is as defined above and R. sub. 7 is R. sub. 7a OC(O)-- wherein R. sub. 7a is loweralkyl; or R. sub. 6 and R. sub. 7 taken together with the nitrogen atom to which they are bonded are ##STR4## wherein R. sub. f, R. sub. g, R. sub. h and R. sub. l are independently selected from hydrogen, loweralkyl, alkoxy, halogen and trifluoromethyl; and R. sub. g is hydrogen, loweralkyl or benzyl; or an acid addition salt thereof.

US Patent:

55435513, Aug 6, 1996

Filed:

Apr 10, 1995

Appl. No.:

8/419301

Inventors:

Timothy L. Stuk - Lindenhurst IL
Michael S. Allen - Silver Lake WI
Anthony R. Haight - Mundelein IL
Francis A. Kerdesky - Grayslake IL
Denton C. Langridge - Wildwood IL
M. Robert Leanna - Grayslake IL
Linda M. Lijewski - Milwaukee WI
Laura Melcher - Deerfield IL
Howard E. Morton - Gurnee IL
Daniel W. Norbeck - Crystal Lake IL
Daniel S. Reno - Kenosha WI
Timothy A. Robbins - Gurnee IL
Hing L. Sham - Mundelein IL
Thomas J. Sowin - Grayslake IL
Chen Zhao - Gurnee IL
David Scarpetti - Baltimore MD

Assignee:

Abbott Laboratories - Abbott Park IL

International Classification:

C07C26100
C07C23300
C07D20904

US Classification:

560 24

Abstract:

Intermediates and processes are disclosed which are useful for the preparation of a substantially pure compound of the formula: ##STR1## wherein R. sub. 6 and R. sub. 7 are each hydrogen or R. sub. 6 and R. sub. 7 are independently selected from ##STR2## wherein R. sub. a and R. sub. b are independently selected from hydrogen, loweralkyl and phenyl and R. sub. c, R. sub. d and R. sub. e are independently selected from hydrogen, loweralkyl, trifluoromethyl, alkoxy, halo and phenyl; and ##STR3## wherein the naphthyl ring is unsubstituted or substituted with one, two or three substitutents independently selected from loweralkyl, trifluoromethyl, alkoxy and halo; or R. sub. 6 is as defined above and R. sub. 7 is R. sub. 7a OC(O)-- wherein R. sub. 7a is loweralkyl or benzyl; or R. sub. 6 and R. sub.

US Patent:

56167768, Apr 1, 1997

Filed:

Apr 7, 1995

Appl. No.:

8/418705

Inventors:

Timothy L. Stuk - Lindenhurst IL
Anthony R. Haight - Mundelein IL
Francis A. J. Kerdesky - Grayslake IL
M. Robert Leanna - Grayslake IL
Howard E. Morton - Gurnee IL
Timothy A. Robbins - Gurnee IL
David Scarpetti - Baltimore MD

Assignee:

Abbott Laboratories - Abbott Park IL

International Classification:

C07C26100
C07C23300

US Classification:

560 27

Abstract:

Intermediates and processes are disclosed which are useful for the preparation of a substantially pure compound of the formula: ##STR1## wherein R. sub. 6 and R. sub. 7 are each hydrogen or R. sub. 6 and R. sub. 7 are independently selected from ##STR2## wherein R. sub. a and R. sub. b are independently selected from hydrogen, loweralkyl and phenyl and R. sub. c, R. sub. d and R. sub. e are independently selected from hydrogen, loweralkyl, trifluoromethyl, alkoxy, halo and phenyl; and ##STR3## wherein the naphthyl ring is unsubstituted or substituted with one, two or three substitutents independently selected from loweralkyl, trifluoromethyl, alkoxy and halo; or R. sub. 6 is as defined above and R. sub. 7 is R. sub. 7a OC(O)-- wherein R. sub.